Cellulitis and Soft Tissue Infections Quiz
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Questions and Answers

What is the most common site for cellulitis to occur?

  • Face and lower legs (correct)
  • Arms and hands
  • Chest and abdomen
  • Back and shoulders
  • Which of the following is NOT a predisposing factor for cellulitis?

  • Dry skin
  • Insect bites
  • High blood pressure (correct)
  • Surgical wounds
  • Which treatment is often prescribed in addition to antibiotics for cellulitis?

  • Radiation therapy
  • Chemotherapy
  • Immune suppression
  • Pain relief (correct)
  • What condition can resemble cellulitis and requires leg ultrasound for investigation?

    <p>Deep vein thrombosis (D)</p> Signup and view all the answers

    Which of the following types of bacteria is most commonly involved in the development of cellulitis?

    <p>Group A streptococci (C)</p> Signup and view all the answers

    Which of the following best describes erysipelas?

    <p>An acute streptococcal infection with well-defined edges (D)</p> Signup and view all the answers

    What is the significance of pain relief in the treatment of cellulitis?

    <p>It can mask symptoms of necrotising fasciitis. (C)</p> Signup and view all the answers

    Which of the following could increase a person's risk of developing cellulitis?

    <p>Obesity (C)</p> Signup and view all the answers

    What is the primary reason for administering high doses of intravenous antibiotics in necrotizing infections?

    <p>To quickly achieve bactericidal concentrations in the affected tissue (C)</p> Signup and view all the answers

    Which combination of antibiotics would be appropriate for a patient with a penicillin allergy suffering from a necrotizing infection?

    <p>Clindamycin and ciprofloxacin (C)</p> Signup and view all the answers

    In the prognosis of necrotizing soft tissue infections, which group category indicates the highest mortality risk based on admission variables?

    <p>Group 3 (6 points) (D)</p> Signup and view all the answers

    Which of the following factors does NOT contribute to the scoring for mortality risk according to the admission variables?

    <p>Presence of lactic acidosis (C)</p> Signup and view all the answers

    When considering empirical therapy for necrotizing infections, which antibiotic should always accompany a broad-spectrum beta-lactam?

    <p>An antibiotic active against anaerobes (A)</p> Signup and view all the answers

    What is a characteristic feature that differentiates erysipelas from cellulitis?

    <p>Erysipelas typically presents with a raised, red rash. (C)</p> Signup and view all the answers

    What type of infection is caused by the synergistic action of streptococci and staphylococci?

    <p>Synergistic gangrene (D)</p> Signup and view all the answers

    Which statement is true regarding the treatment of synergistic gangrene?

    <p>Radical excision of the ulcerated lesion is often necessary. (C)</p> Signup and view all the answers

    What is a common clinical finding associated with gas gangrene?

    <p>Presence of black necrotic tissue (B)</p> Signup and view all the answers

    What is one of the key characteristic symptoms of gas gangrene?

    <p>Purplish-black affected area (C)</p> Signup and view all the answers

    What is a critical factor that can increase the mortality rate of gas gangrene?

    <p>Delay in diagnosis (D)</p> Signup and view all the answers

    Which preventive measure is critical after the resolution of an initial infection?

    <p>Use of prophylactic antibiotics (C)</p> Signup and view all the answers

    Which of the following describes gas gangrene's bacterial involvement?

    <p>It is caused by anaerobic infection of muscle. (C)</p> Signup and view all the answers

    What typical areas of the body are most commonly affected by erysipelas?

    <p>The face, arms, fingers, legs, and toes (C)</p> Signup and view all the answers

    Which of the following organisms is primarily responsible for most cases of erysipelas?

    <p>Streptococcus pyogenes (B)</p> Signup and view all the answers

    What is a distinguishing feature of erysipelas compared to cellulitis?

    <p>It has a sharply demarcated raised edge (B)</p> Signup and view all the answers

    Which symptom is considered a constitutional symptom of erysipelas?

    <p>High fevers and shaking chills (C)</p> Signup and view all the answers

    What is a common complication of untreated erysipelas?

    <p>Bacteremia leading to septic shock (B)</p> Signup and view all the answers

    Which antibiotic is generally preferred for treating erysipelas?

    <p>Penicillin (C)</p> Signup and view all the answers

    What occurs approximately 10 days after the onset of erysipelas?

    <p>Elevation of antistreptolysin O titers (D)</p> Signup and view all the answers

    What may happen if erysipelas recurs after antibiotic treatment?

    <p>Increase in chronic swelling (lymphedema) (C)</p> Signup and view all the answers

    What is the main reason for the immediate removal of muscle groups in gas gangrene?

    <p>If remaining viable muscles are insufficient for useful function (C)</p> Signup and view all the answers

    What is the typical mortality rate for untreated gas gangrene?

    <p>Always fatal (C)</p> Signup and view all the answers

    Which of the following is a common symptom of necrotizing fasciitis?

    <p>Intense pain at the site of infection (A)</p> Signup and view all the answers

    What treatment is typically required after excision of the affected area in necrotizing fasciitis?

    <p>Skin grafting (D)</p> Signup and view all the answers

    What agents are primarily responsible for necrotizing fasciitis?

    <p>Hemolytic streptococci and staphylococci (A)</p> Signup and view all the answers

    What can hyperbaric oxygen treatments potentially reduce in cases of gas gangrene?

    <p>The need for debridement (C)</p> Signup and view all the answers

    How quickly can symptoms of necrotizing fasciitis manifest after infection occurs?

    <p>Within hours to six days (C)</p> Signup and view all the answers

    What is a characteristic feature of the tissue destruction caused by necrotizing fasciitis?

    <p>Bacteria release toxins leading to tissue dissolution. (C)</p> Signup and view all the answers

    Flashcards

    What is cellulitis?

    Inflammation of the deeper layers of skin, often affecting the face or lower legs. It's caused by bacteria like Group A streptococcus, which enter through skin cracks or breaks.

    What are predisposing factors for cellulitis?

    Factors that increase the risk of developing cellulitis, for example, skin cracks, cuts, burns, insect bites, or weak immune systems.

    How is cellulitis diagnosed?

    Cellulitis is often diagnosed based on symptoms and appearance. Swabs may not always show the specific bacteria. Blood cultures are usually positive only if there is sepsis.

    How is cellulitis treated?

    Treating cellulitis involves rest, wound cleaning if present, and antibiotics. Severe cases might require hospitalisation and intravenous antibiotics.

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    What is Erysipelas?

    A superficial skin infection caused by a type of bacteria called Group A streptococcus, affecting the upper layer of the skin, causing redness and swelling with a clear border.

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    Who is at risk for Erysipelas?

    People more likely to get Erysipelas are the elderly, infants, those with weak immune systems, diabetes, or lymphatic drainage issues.

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    What makes Erysipelas and Cellulitis hard to tell apart?

    Erysipelas and cellulitis often look similar, making it difficult to distinguish between the two.

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    What is Necrotizing Fasciitis?

    Necrotizing fasciitis is a serious infection that can spread rapidly and destroy tissue. It requires urgent surgical attention, with immediate antibiotics and potentially hyperbaric oxygen therapy.

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    Erysipelas

    A bacterial skin infection, typically caused by Streptococcus pyogenes, characterized by a sharply defined, raised, red, swollen, and painful rash.

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    Necrotizing Fasciitis

    A serious complication of erysipelas where the infection spreads to deeper tissues, causing tissue death.

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    Constitutional Symptoms of Erysipelas

    High fever, chills, fatigue, headache, vomiting, and rapid enlargement of the inflamed skin lesion.

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    Characteristic Appearance of Erysipelas

    The skin lesion in erysipelas has a distinct raised edge, resembling an orange peel.

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    Treatment for Erysipelas

    Antibiotics like penicillin, clindamycin, erythromycin, or cephalosporins are used to treat erysipelas.

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    Recurrent Erysipelas

    Erysipelas can recur in 18-30% of cases, even after treatment.

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    Common Areas Affected by Erysipelas

    Erysipelas most commonly affects the face (especially around the eyes, ears, and cheeks), arms, fingers, legs, and toes.

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    Distinguishing Erysipelas from Cellulitis

    Erysipelas can be distinguished from cellulitis by its raised advancing edges and sharp borders.

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    What is synergistic gangrene?

    Synergistic gangrene is a type of chronic bacterial infection caused by the combined action of streptococci and staphylococci, leading to progressive ulceration.

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    What causes Gas gangrene?

    Clostridium perfringens bacteria infect muscle tissue in the presence of dead muscle, releasing toxins that destroy tissue and blood cells.

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    What is Gas gangrene?

    Gas gangrene is a severe, rapidly spreading infection of muscle tissue caused by Clostridium perfringens bacteria, producing toxins that destroy tissue.

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    How does Gas gangrene affect the muscle?

    The affected muscles in Gas gangrene turn red and friable, then progress to purplish black, swelling and releasing a brownish, malodorous fluid.

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    How is Gas gangrene diagnosed?

    The diagnosis of Gas gangrene is based on clinical findings and the presence of large, Gram-positive rods in wound fluid, delaying diagnosis significantly increases mortality.

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    Why are prophylactic antibiotics sometimes used?

    Prophylactic antibiotics are sometimes used after clearing the initial condition to prevent reinfection.

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    Why are combination antibiotics important in Necrotizing Fasciitis?

    A combination of antibiotics is crucial for necrotizing fasciitis because it targets a wide range of bacteria, including both aerobes and anaerobes.

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    What types of antibiotics are often used for Necrotizing Fasciitis?

    Penicillin, vancomycin, and clindamycin are commonly used to treat necrotizing fasciitis. These drugs work by killing bacteria or preventing their growth.

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    What's the mortality rate of Necrotizing Fasciitis if left untreated?

    The mortality rate of Necrotizing Fasciitis is high, reaching 73% if left untreated.

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    How can we predict the outcome of Necrotizing Fasciitis?

    A clinical score helps assess the risk of death in patients with necrotizing fasciitis. Factors like heart rate, temperature, kidney function, age, and blood count are important.

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    What bacteria are involved in Necrotizing Fasciitis?

    A mix of bacteria, often including streptococci and staphylococci, causes necrotizing fasciitis, with peptostreptococci contributing a significant role.

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    What tissue does Necrotizing Fasciitis affect?

    The infection attacks the connective tissue (fascia) beneath the skin, rapidly spreading and destroying tissue.

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    What is a major symptom of Necrotizing Fasciitis?

    Intense pain at the infection site is a key symptom, often developing rapidly alongside swelling even in the early stages.

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    How is Necrotizing Fasciitis treated?

    Aggressive surgical debridement (removal of infected tissue) is crucial, often involving fascia excision, leaving large wounds needing skin grafts.

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    When is amputation a possible treatment for Necrotizing Fasciitis?

    In cases where remaining muscle is insufficient for function after debridement, amputation may be necessary to stop infection spread.

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    What is a supplementary treatment for Necrotizing Fasciitis?

    Hyperbaric oxygen therapy (increased oxygen pressure) can sometimes reduce the need for debridement, but must not delay surgical intervention.

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    What is the prognosis for Necrotizing Fasciitis?

    Untreated Necrotizing Fasciitis is always fatal, and even with treatment, the mortality rate is high (25-40%).

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    Study Notes

    Skin and Soft-Tissue Infections

    • Cellulitis is a diffuse inflammation of connective tissue (dermal and subcutaneous layers)
    • Commonly affects skin on the face or lower legs
    • Caused by normal skin flora or exogenous bacteria (e.g., Group A streptococci)
    • Bacteria easily breach defensive barriers due to toxins
    • Lymphatic system is involved

    Predisposing Factors

    • Cracks in skin (dry skin, eczema, tattoos)
    • Cuts and blisters
    • Burns
    • Insect bites
    • Animal bites
    • Surgical wounds
    • Intravenous catheter insertion sites
    • Injecting drug use
    • Pregnancy, diabetes, obesity, chronic venous insufficiency, and varicose veins (affect circulation)
    • Breaks in the skin do not need to be visible

    Diagnosis

    • Often a clinical diagnosis
    • Local cultures may not identify the causative organism
    • Blood cultures are positive only if generalized sepsis develops
    • Conditions that mimic cellulitis include deep vein thrombosis, stasis dermatitis, and Lyme disease

    Treatment

    • Rest the affected limb/area
    • Clean the wound (with debridement of dead tissue if needed)
    • Oral antibiotics, but in severe cases, IV antibiotics are used
    • Example antibiotics: Flucloxacillin, benzylpenicillin, ampicillin/amoxicillin
    • Pain relief is important, but excessive pain may indicate necrotizing fasciitis (requires emergency surgery)
    • Hyperbaric oxygen therapy can be helpful but not widely available

    Erysipelas

    • An acute streptococcal infection of the superficial dermis (upper subcutaneous dermis)
    • Results in inflammation
    • Has a well-defined edge
    • Often coexists with cellulitis, making differentiation difficult
    • Commonly affects the face, arms, fingers, legs, and toes.
    • Older people, infants, children are at increased risk
    • Risk factors include compromised immune systems, diabetes, alcoholism, skin ulceration, fungal infections, impaired lymphatic drainage (e.g., after mastectomy, pelvic surgery).

    Signs and Symptoms Erysipelas

    • Constitutional symptoms (high fevers, chills, fatigue, headaches, vomiting)
    • Rapidly enlarging, erythematous (red) skin lesion
    • Sharply demarcated, raised edge
    • Warm, hardened, painful rash
    • Rash similar in consistency to an orange peel
    • More severe cases may result in vesicles, bullae, and petechiae, with possible skin necrosis
    • Lymph nodes may be swollen or lymphedema may occur
    • Fat tissue is particularly susceptible to infection

    Etiology Erysipelas

    • Most cases are due to Streptococcus pyogenes (beta-hemolytic group A streptococci)

    Diagnosis Erysipelas

    • Appearance of well-demarcated rash and inflammation
    • Blood cultures are unreliable
    • Distinguished from cellulitis by raised advancing edges and sharp borders
    • Elevation of antistreptolysin O titre around 10 days after illness

    Complications

    • Spread to other body areas (bacteremia), including septic arthritis and infective endocarditis (heart valves)
    • Septic shock
    • Recurrence (18-30% even after antibiotic treatment)
    • Lymphatic damage
    • Necrotizing fasciitis (a potentially deadly exacerbation)
    • Death

    Treatment (Erysipelas)

    • Oral or preferably intravenous antibiotics
      • Penicillin
      • Clindamycin
      • Erythromycin
      • Cephalosporins
    • Symptoms usually resolve in a day or two; skin may take weeks to return to normal

    Prevention

    • Clean and appropriately dress wounds
    • Change bandages daily
    • Remove retained foreign bodies

    Necrotizing Infections

    • Synergistic gangrene: Chronic, progressive bacterial gangrene caused by the synergistic action of streptococci and staphylococci

      • Incubation period: 7-14 days
      • Cellulitis progression with gangrenous ulceration
      • Treatment: Radical excision of the ulcerated lesion and large systemic doses of penicillin
    • Gas gangrene: Anaerobic infection of muscle by Clostridium perfringens, producing toxins that destroy tissue and blood cells

      • Disrupts and fragments normal muscle ,causes hemorrhage and edema, progresses to a purplish black
      • Fluid discharge is commonly present and is brownish and malodorous
      • Often affected areas initially are mottled (ecchymotic) and progress to blackening, and sloughing
      • Diagnosis based on typical clinical findings in wound fluid, presence of large Gram-positive rods
      • Delays in diagnosis, greatly increase the mortality
      • Immediate removal of involved muscle groups may be necessary, with potential amputation
      • High intravenous doses of penicillin and whole blood, possibly multiple hyperbaric oxygen treatments.
    • Necrotizing fasciitis: Serious mixed infection of hemolytic streptococci/staphylococci and peptostreptococci, producing toxins that destroy connective tissue

      • Characterized by intense pain, rapid swelling, discoloration, blisters, necrosis, diarrhea, vomiting, high fever.
      • Infection originates at operative wounds, lacerations, abrasions, or punctures.
      • It may be immediately fulminant or dormant for several days before rapidly spreading
    • Aggressive surgical debridement and large intravenous doses antibiotics (including penicillin, vancomycin, and clindamycin)

      • Possible amputation, intensive treatment, high fatality rate untreated.

    Management of Necrotizing Infections

    • IV antibiotics in high doses, to quickly reach bactericidal concentrations.
    • Empirical therapy must comprehensively cover all possible pathogens (aerobes and anaerobes) and must be supplementary to surgical procedures.

    Empirical therapy

    • Broad-spectrum penicillin (amoxicillin) + metronidazole + aminoglycoside (gentamicin)
    • Second-generation cephalosporin (cefuroxime) + metronidazole
    • Penicillin allergy: clindamycin + quinolone (e.g., ciprofloxacin)
    • Immunocompromised patients, require quinolones for possible Pseudomonas infections.

    Prognosis (Mortality) - Necrotizing Soft Tissue Infections

    • Clinical score on admission can predict mortality.
    • High heart rate, low body temperature, high creatinine, advancing age, high white blood cell count, and high hematocrit are all risk factors.

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    Description

    Test your knowledge on cellulitis and related soft tissue infections with this quiz. Explore essential questions about causes, treatments, and characteristics, including the comparison with conditions that resemble cellulitis. Ideal for medical students and healthcare professionals alike.

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