Cellular Pathways: Intrinsic and Necrosis

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What is the primary function of the intrinsic pathway during development?

Elimination of damaged cells

Initiation of inflammation

Immune system regulation and tissue remodeling (correct)

Cell proliferation

What is the characteristic of necrosis?

Gradual loss of membrane integrity and cellular shrinkage

Controlled cell death with membrane integrity

Rapid loss of membrane integrity and release of cellular contents (correct)

Programmed cell death with DNA fragmentation

What is the consequence of chronic inflammation?

Apoptosis

Immune system regulation

Tissue repair and healing

Tissue damage and organ dysfunction (correct)

What is the underlying cause of atherosclerosis?

Buildup of fatty deposits, cholesterol, and cellular waste products Signup and view all the answers

What is the main difference between healthy and pathological inflammation?

Controlled versus dysregulated immune response Signup and view all the answers

Which disease is associated with dysregulation of the intrinsic pathway?

All of the above Signup and view all the answers

What is the primary mechanism by which LDL accumulates in the initiation phase of atherosclerosis?

Scarb1-mediated transcytosis Signup and view all the answers

Which immune cells regulate the functions of innate immune cells, endothelial cells, and smooth muscle cells in the initiation phase?

CD4+ T lymphocytes Signup and view all the answers

What is the consequence of increased production of collagenase (Mmp8) enzymes by activated macrophages in the progression phase?

Thinning of the collagen-rich cap Signup and view all the answers

What is the result of foam cells and smooth muscle cells undergoing apoptosis in the progression phase?

Formation of a necrotic lipid-rich core Signup and view all the answers

What is the consequence of plaque rupture in the complications phase?

Formation of a thrombus Signup and view all the answers

What is the characteristic of clots associated with superficial erosion?

Platelet-rich 'white' thrombi Signup and view all the answers

What is a major limitation in understanding spinal cord injuries?

Inability to harvest spinal cord tissue during disease progression Signup and view all the answers

What is the primary focus of translational research?

Understanding human biology, especially in disease scenarios Signup and view all the answers

Why is it essential to study spinal cord injuries at the molecular and cellular level?

To identify potential therapeutic targets for treatment Signup and view all the answers

What is the primary difference between translational research and basic science research?

The focus of the research Signup and view all the answers

What can clinical research provide in the context of spinal cord injuries?

Imaging and analysis of blood and cerebrospinal fluid Signup and view all the answers

What is an example of a population-level strategy to prevent spinal cord injuries?

Providing education on safe diving practices Signup and view all the answers