Cellular Pathways: Intrinsic and Necrosis
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Questions and Answers

What is the primary function of the intrinsic pathway during development?

  • Elimination of damaged cells
  • Initiation of inflammation
  • Immune system regulation and tissue remodeling (correct)
  • Cell proliferation

What is the characteristic of necrosis?

  • Gradual loss of membrane integrity and cellular shrinkage
  • Controlled cell death with membrane integrity
  • Rapid loss of membrane integrity and release of cellular contents (correct)
  • Programmed cell death with DNA fragmentation

What is the consequence of chronic inflammation?

  • Apoptosis
  • Immune system regulation
  • Tissue repair and healing
  • Tissue damage and organ dysfunction (correct)

What is the underlying cause of atherosclerosis?

<p>Buildup of fatty deposits, cholesterol, and cellular waste products (D)</p> Signup and view all the answers

What is the main difference between healthy and pathological inflammation?

<p>Controlled versus dysregulated immune response (B)</p> Signup and view all the answers

Which disease is associated with dysregulation of the intrinsic pathway?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary mechanism by which LDL accumulates in the initiation phase of atherosclerosis?

<p>Scarb1-mediated transcytosis (B)</p> Signup and view all the answers

Which immune cells regulate the functions of innate immune cells, endothelial cells, and smooth muscle cells in the initiation phase?

<p>CD4+ T lymphocytes (D)</p> Signup and view all the answers

What is the consequence of increased production of collagenase (Mmp8) enzymes by activated macrophages in the progression phase?

<p>Thinning of the collagen-rich cap (B)</p> Signup and view all the answers

What is the result of foam cells and smooth muscle cells undergoing apoptosis in the progression phase?

<p>Formation of a necrotic lipid-rich core (C)</p> Signup and view all the answers

What is the consequence of plaque rupture in the complications phase?

<p>Formation of a thrombus (B)</p> Signup and view all the answers

What is the characteristic of clots associated with superficial erosion?

<p>Platelet-rich 'white' thrombi (A)</p> Signup and view all the answers

What is a major limitation in understanding spinal cord injuries?

<p>Inability to harvest spinal cord tissue during disease progression (B)</p> Signup and view all the answers

What is the primary focus of translational research?

<p>Understanding human biology, especially in disease scenarios (B)</p> Signup and view all the answers

Why is it essential to study spinal cord injuries at the molecular and cellular level?

<p>To identify potential therapeutic targets for treatment (C)</p> Signup and view all the answers

What is the primary difference between translational research and basic science research?

<p>The focus of the research (C)</p> Signup and view all the answers

What can clinical research provide in the context of spinal cord injuries?

<p>Imaging and analysis of blood and cerebrospinal fluid (B)</p> Signup and view all the answers

What is an example of a population-level strategy to prevent spinal cord injuries?

<p>Providing education on safe diving practices (A)</p> Signup and view all the answers

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