Signaling of Cell Death (Apoptosis)
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Questions and Answers

Which organelle is mainly responsible for regulating the intrinsic pathway of apoptosis?

  • Endoplasmic reticulum
  • Golgi apparatus
  • Lysosome
  • Mitochondria (correct)
  • Which type of DNA fragmentation occurs during apoptosis where the DNA breaks into fragments resembling a ladder pattern?

  • Random DNA fragmentation
  • Condensed DNA fragmentation
  • Ladder-like DNA fragmentation (correct)
  • Smeared DNA fragmentation
  • Which type of caspases are responsible for initiating the apoptosis process by activating downstream caspases?

  • Regulatory caspases
  • Executioner caspases
  • Inhibitory caspases
  • Initiator caspases (correct)
  • Which trophic factors can prevent apoptosis by inactivating pro-apoptotic regulators?

    <p>IAP inhibitors</p> Signup and view all the answers

    Which pathway of apoptosis is activated by the ligation of death receptors such as Fas and TNF alpha?

    <p>Extrinsic pathway</p> Signup and view all the answers

    What is the main outcome of apoptosis at the cellular level?

    <p>Cell death with no tissue reaction</p> Signup and view all the answers

    What is the main characteristic of apoptosis described in the text?

    <p>Carefully coordinated collapse of cell</p> Signup and view all the answers

    Which of the following is NOT a reason for a cell to undergo apoptosis?

    <p>Cells subjected to growth factors</p> Signup and view all the answers

    In what scenario is apoptosis needed according to the text?

    <p>To destroy cancer cells</p> Signup and view all the answers

    What is a common signaling molecule mentioned in the text that can activate the pathways leading to apoptosis?

    <p>Tumor necrosis factor alpha</p> Signup and view all the answers

    Which of the following is a reason for excess apoptosis mentioned in the text?

    <p>Causing neurodegenerative diseases</p> Signup and view all the answers

    What type of damage can trigger apoptosis, as discussed in the text?

    <p>Damage caused by increased oxidants</p> Signup and view all the answers

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