Signaling of Cell Death (Apoptosis)

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Questions and Answers

Which organelle is mainly responsible for regulating the intrinsic pathway of apoptosis?

  • Endoplasmic reticulum
  • Golgi apparatus
  • Lysosome
  • Mitochondria (correct)

Which type of DNA fragmentation occurs during apoptosis where the DNA breaks into fragments resembling a ladder pattern?

  • Random DNA fragmentation
  • Condensed DNA fragmentation
  • Ladder-like DNA fragmentation (correct)
  • Smeared DNA fragmentation

Which type of caspases are responsible for initiating the apoptosis process by activating downstream caspases?

  • Regulatory caspases
  • Executioner caspases
  • Inhibitory caspases
  • Initiator caspases (correct)

Which trophic factors can prevent apoptosis by inactivating pro-apoptotic regulators?

<p>IAP inhibitors (A)</p> Signup and view all the answers

Which pathway of apoptosis is activated by the ligation of death receptors such as Fas and TNF alpha?

<p>Extrinsic pathway (D)</p> Signup and view all the answers

What is the main outcome of apoptosis at the cellular level?

<p>Cell death with no tissue reaction (C)</p> Signup and view all the answers

What is the main characteristic of apoptosis described in the text?

<p>Carefully coordinated collapse of cell (C)</p> Signup and view all the answers

Which of the following is NOT a reason for a cell to undergo apoptosis?

<p>Cells subjected to growth factors (B)</p> Signup and view all the answers

In what scenario is apoptosis needed according to the text?

<p>To destroy cancer cells (C)</p> Signup and view all the answers

What is a common signaling molecule mentioned in the text that can activate the pathways leading to apoptosis?

<p>Tumor necrosis factor alpha (D)</p> Signup and view all the answers

Which of the following is a reason for excess apoptosis mentioned in the text?

<p>Causing neurodegenerative diseases (D)</p> Signup and view all the answers

What type of damage can trigger apoptosis, as discussed in the text?

<p>Damage caused by increased oxidants (D)</p> Signup and view all the answers

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