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Questions and Answers
What is the primary use of Cefazolin?
How is Cefazolin primarily eliminated from the body?
What is the stability of Cefazolin against beta-lactamase compared to Penicillins?
What type of administration is used for Cefazolin?
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Which statement about Cefazolin is correct regarding cross-sensitivity?
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What is a significant characteristic of Cefazolin in relation to gastric acid?
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Which of the following statements about dosage adjustments for Cefazolin is accurate?
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In terms of resistance to beta-lactamase, Cefazolin is considered:
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For what purpose is Cefazolin frequently used?
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Which of these scenarios would likely indicate a cross-sensitivity concern with Cefazolin?
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Study Notes
Cefazolin Overview
- Cefazolin, marketed as Ancef®, is an intravenous (IV) antibiotic.
- Frequently utilized for surgical prophylaxis to prevent infections during and after procedures.
Pharmacological Characteristics
- More resistant to beta-lactamase enzymes compared to penicillins (PCNs), enhancing effectiveness in certain infections.
- Administered IV as oral forms would be destroyed by gastric acid, ensuring drug stability and efficacy.
Pharmacokinetics
- Renally eliminated, requiring dose adjustments in patients with renal impairment to avoid toxicity.
- Inactivated by beta-lactamase, though it demonstrates greater stability than traditional penicillins.
Clinical Considerations
- Potential for cross-sensitivity with other beta-lactam antibiotics, necessitating careful patient history review for allergies.
Cefazolin Overview
- Cefazolin, marketed as Ancef®, is an intravenous (IV) antibiotic.
- Frequently utilized for surgical prophylaxis to prevent infections during and after procedures.
Pharmacological Characteristics
- More resistant to beta-lactamase enzymes compared to penicillins (PCNs), enhancing effectiveness in certain infections.
- Administered IV as oral forms would be destroyed by gastric acid, ensuring drug stability and efficacy.
Pharmacokinetics
- Renally eliminated, requiring dose adjustments in patients with renal impairment to avoid toxicity.
- Inactivated by beta-lactamase, though it demonstrates greater stability than traditional penicillins.
Clinical Considerations
- Potential for cross-sensitivity with other beta-lactam antibiotics, necessitating careful patient history review for allergies.
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Description
This quiz covers the essential aspects of Cefazolin, including its pharmacological characteristics, pharmacokinetics, and clinical considerations. Learn about its use in surgical prophylaxis, resistance to beta-lactamase, and implications for renal impairment. Test your knowledge of this crucial intravenous antibiotic.
