Cefazolin (Ancef) Flashcards

Questions and Answers

What is the drug class of Cefazolin?

First generation cephalosporin (correct)

Macrolide

Second generation cephalosporin

Penicillin

What is the pregnancy category of Cefazolin?

What are therapeutic uses of Cefazolin?

To treat bone and joint infections, genital infections, and endocarditis; also used for respiratory, urinary, and skin infections.

What is the mode of action of Cefazolin?

Inhibition of cell wall synthesis, causing cell death; bactericidal effect. Signup and view all the answers

Which of the following are potential side effects of Cefazolin? (Select all that apply)

Abdominal cramps Signup and view all the answers

What are some adverse reactions associated with Cefazolin?

Superinfections, urticarial, seizures (high doses), and anaphylaxis. Signup and view all the answers

What are the contraindications for using Cefazolin?

Hypersensitivity to cephalosporins; caution with hypersensitivity to penicillins, renal disease, and during lactation. Signup and view all the answers

What are some drug interactions with Cefazolin?

Increase effect with probenecid; increase toxicity with loop diuretics, aminoglycosides, colistin, vancomycin; decrease effect with tetracyclines and erythromycin. Signup and view all the answers

What lab interactions may occur with Cefazolin?

May increase BUN, serum creatinine, AST, ALT, ALP, LDH, bilirubin. Signup and view all the answers

What are the pharmacokinetics of Cefazolin?

Absorption: IM, IV; Distribution: PB: 85%; Metabolism: 1.5-2.5 hrs; Excretion: 70% excreted unchanged in urine. Signup and view all the answers

What are the pharmacodynamics characteristics for IM and IV administration of Cefazolin?

IM: Onset: rapid; Peak: 0.5-2hr; IV: Onset: immediate; Peak: 5-15min. Signup and view all the answers

Study Notes

Drug Class

Classified as a first generation cephalosporin antibiotic.

Pregnancy Category

Assigned category B, indicating no known risks to human fetus based on available studies.

Therapeutic Uses

Treats bone and joint infections, genital infections, and endocarditis.
Effective against respiratory, urinary, and skin infections when combined with cefaclor.

Mode of Action

Functions by inhibiting cell wall synthesis, which leads to bacterial cell death.
Demonstrates a bactericidal effect.

Side Effects

Common side effects include abdominal cramps and fever.
Other effects with cefazolin and cefaclor may include anorexia, nausea, vomiting, diarrhea, and rash.

Adverse Reactions

Potential for superinfections and urticarial reactions with cefazolin and cefaclor.
Life-threatening adverse effects of cefazolin can include seizures (especially at high doses) and anaphylaxis.

Contraindications

Should not be used in patients with hypersensitivity to cephalosporins.
Caution is advised for those with a history of hypersensitivity to penicillins, renal disease, or during lactation.

Drug Interactions

Probenecid can enhance the effects of cefazolin and cefaclor.
May increase toxicity when used with loop diuretics, aminoglycosides, colistin, or vancomycin.
Effectiveness can be decreased when used with tetracyclines or erythromycin.

Lab Interactions

May result in increased levels of BUN, serum creatinine, AST, ALT, ALP, LDH, and bilirubin.

Pharmacokinetics

Administered via intramuscular (IM) or intravenous (IV) routes.
Plasma binding at approximately 85%.
Exhibits a metabolism time of 1.5 to 2.5 hours.
Around 70% is excreted unchanged in urine.

Pharmacodynamics

For IM administration: rapid onset, peak effects within 0.5 to 2 hours, duration unclear.
For IV administration: immediate onset, peak effects within 5 to 15 minutes, duration unclear.

Description

This quiz features essential flashcards on Cefazolin (Ancef), a first generation cephalosporin antibiotic. It covers key topics such as drug class, pregnancy category, therapeutic uses, and mode of action. Ideal for students and healthcare professionals looking to enhance their understanding of this medication.