Podcast
Questions and Answers
What is the drug class of Cefazolin?
What is the drug class of Cefazolin?
What is the pregnancy category of Cefazolin?
What is the pregnancy category of Cefazolin?
B
What are therapeutic uses of Cefazolin?
What are therapeutic uses of Cefazolin?
To treat bone and joint infections, genital infections, and endocarditis; also used for respiratory, urinary, and skin infections.
What is the mode of action of Cefazolin?
What is the mode of action of Cefazolin?
Signup and view all the answers
Which of the following are potential side effects of Cefazolin? (Select all that apply)
Which of the following are potential side effects of Cefazolin? (Select all that apply)
Signup and view all the answers
What are some adverse reactions associated with Cefazolin?
What are some adverse reactions associated with Cefazolin?
Signup and view all the answers
What are the contraindications for using Cefazolin?
What are the contraindications for using Cefazolin?
Signup and view all the answers
What are some drug interactions with Cefazolin?
What are some drug interactions with Cefazolin?
Signup and view all the answers
What lab interactions may occur with Cefazolin?
What lab interactions may occur with Cefazolin?
Signup and view all the answers
What are the pharmacokinetics of Cefazolin?
What are the pharmacokinetics of Cefazolin?
Signup and view all the answers
What are the pharmacodynamics characteristics for IM and IV administration of Cefazolin?
What are the pharmacodynamics characteristics for IM and IV administration of Cefazolin?
Signup and view all the answers
Study Notes
Drug Class
- Classified as a first generation cephalosporin antibiotic.
Pregnancy Category
- Assigned category B, indicating no known risks to human fetus based on available studies.
Therapeutic Uses
- Treats bone and joint infections, genital infections, and endocarditis.
- Effective against respiratory, urinary, and skin infections when combined with cefaclor.
Mode of Action
- Functions by inhibiting cell wall synthesis, which leads to bacterial cell death.
- Demonstrates a bactericidal effect.
Side Effects
- Common side effects include abdominal cramps and fever.
- Other effects with cefazolin and cefaclor may include anorexia, nausea, vomiting, diarrhea, and rash.
Adverse Reactions
- Potential for superinfections and urticarial reactions with cefazolin and cefaclor.
- Life-threatening adverse effects of cefazolin can include seizures (especially at high doses) and anaphylaxis.
Contraindications
- Should not be used in patients with hypersensitivity to cephalosporins.
- Caution is advised for those with a history of hypersensitivity to penicillins, renal disease, or during lactation.
Drug Interactions
- Probenecid can enhance the effects of cefazolin and cefaclor.
- May increase toxicity when used with loop diuretics, aminoglycosides, colistin, or vancomycin.
- Effectiveness can be decreased when used with tetracyclines or erythromycin.
Lab Interactions
- May result in increased levels of BUN, serum creatinine, AST, ALT, ALP, LDH, and bilirubin.
Pharmacokinetics
- Administered via intramuscular (IM) or intravenous (IV) routes.
- Plasma binding at approximately 85%.
- Exhibits a metabolism time of 1.5 to 2.5 hours.
- Around 70% is excreted unchanged in urine.
Pharmacodynamics
- For IM administration: rapid onset, peak effects within 0.5 to 2 hours, duration unclear.
- For IV administration: immediate onset, peak effects within 5 to 15 minutes, duration unclear.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
This quiz features essential flashcards on Cefazolin (Ancef), a first generation cephalosporin antibiotic. It covers key topics such as drug class, pregnancy category, therapeutic uses, and mode of action. Ideal for students and healthcare professionals looking to enhance their understanding of this medication.
