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ketamin treatment
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ketamin treatment

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Questions and Answers

What was the purpose of the mindfulness training in the study mentioned?

  • To enhance negative reactivity during infusion
  • To decrease cognitive flexibility
  • To promote healing and resilient experiences during and after infusion (correct)
  • To decrease positive and neutral thinking

    • Which criterion was NOT part of the exclusion criteria for patient recruitment in the study?

  • all the above (correct)
  • Severe liver dysfunction
  • Poorly managed hypertension
  • Elevated intracranial or intraocular pressure

    • What was the intravenous dose of ketamine hydrochloride used in the St. Michael’s Institutional Infusion Protocol?

  • 0.5 mg/kg over 2 hrs
  • 1 mg/kg over 1 hr
  • 1 mg/kg over 2 hrs (correct)
  • 2 mg/kg over 2 hrs

    • What is a key aspect of the MBCT Protocol used in the study?

    <p>Internet workbooks and instructional videos</p> Signup and view all the answers

    Which feasibility measure was NOT considered in the study?

    <p>Average age of participants</p> Signup and view all the answers

    How does Cognitive Flexibility impact cognitive-behavioral learning according to the text?

    <p>Enhances cognitive-behavioral learning</p> Signup and view all the answers

    What is the primary focus of the Canada's first KAP trial for NeP?

    <p>Determining the impact of CBT on ketamine therapy</p> Signup and view all the answers

    What is a core-domain question addressed in the study?

    <p>Experiences related to pain and physical functioning</p> Signup and view all the answers

    What will determine the feasibility of the Canada's first KAP trial for NeP?

    <p>Results from the trial</p> Signup and view all the answers

    What is being compared in the standard-care + online CBT – MM intervention study?

    <p>BDI-2 scores from baseline to 6 months</p> Signup and view all the answers

    What scale is used to assess Patient Global Impression of Change (PGIC) in the trial?

    <p>Patient perception of global improvement scale</p> Signup and view all the answers

    What aspect is addressed by the Inductive Probes in the study?

    <p>Mechanisms of change in response to ketamine therapy</p> Signup and view all the answers

    What is a potential outcome of synergies between ketamine response, CBT, and mindfulness?

    <p>Better health outcomes</p> Signup and view all the answers

    In the context of the text, what is the suggested impact of CBT on ketamine therapy?

    <p>Reduction in ketamine-induced anxiety</p> Signup and view all the answers

    How are psychoactive effects of ketamine described in comparison to psychedelic effects?

    <p>They are less intense than psychedelic effects</p> Signup and view all the answers

    What is the main benefit of combining CBT with Mindfulness in the context of Ketamine therapy?

    <p>Enhanced rapid analgesia</p> Signup and view all the answers

    Which factor is NOT emphasized as part of patient recruitment criteria for ketamine-assisted psychotherapy?

    <p>Resolve phone challenges early (scheduling)</p> Signup and view all the answers

    How does Ketamine impact NMDA receptors?

    <p>It blocks the receptor</p> Signup and view all the answers

    What potential benefit is implied by the text regarding mindfulness training in conjunction with ketamine therapy?

    <p>Enhanced outcomes if mystical experiences occur</p> Signup and view all the answers

    How are positive effects suggested to be impacted if a patient experiences ketamine-induced anxiety during treatment?

    <p>Positive effects are reduced due to ketamine-induced anxiety</p> Signup and view all the answers

    What is a common limitation in the treatment durability of Ketamine according to research literature?

    <p>Limited duration of effect</p> Signup and view all the answers

    How can patient recruitment criteria potentially impact Ketamine therapy outcomes?

    <p>By influencing the generalizability of research findings</p> Signup and view all the answers

    Which of the following is a potential benefit of mindfulness training in the context of pain management?

    <p>Reducing pain perception through distraction techniques</p> Signup and view all the answers

    How does compassion play a role as an analgesic and antidepressant in the context of Ketamine therapy?

    <p>Serves as a supportive factor for pain relief and mood improvement</p> Signup and view all the answers

    What is the primary purpose of the randomized controlled trial funded by the PSI Foundation?

    <p>To explore potential synergisms between psychotherapy and ketamine in chronic neuropathic pain.</p> Signup and view all the answers

    Why is ketamine considered burdensome despite its potent short-term benefits?

    <p>It requires repeated and ongoing therapy which can be challenging for patients and clinicians.</p> Signup and view all the answers

    What is one of the four primary goals of the study investigating ketamine and psychotherapy synergy?

    <p>Test and inform hypotheses about the effectiveness of combining ketamine and psychotherapy.</p> Signup and view all the answers

    Based on the text, what challenges do chronic pain therapies typically face?

    <p>Low durability, adverse side effects, and variable efficacy.</p> Signup and view all the answers

    Why is the study mentioned significant in the context of chronic pain management?

    <p>It addresses the limitations of current therapies by exploring synergies between psychotherapy and ketamine.</p> Signup and view all the answers

    What aspect leads to the growing burden of ketamine therapy mentioned in the text?

    <p>The need for repeated and ongoing therapy among patients and clinicians.</p> Signup and view all the answers

    The Toronto Side Effects Scale is used to monitor adverse events per FDA regulations.

    <p>False</p> Signup and view all the answers

    The PROMIS Pain Interference - Short Form v1.1 assesses emotional functioning.

    <p>False</p> Signup and view all the answers

    The Patient Health Questionnaire-9 (PHQ-9) is used to assess generalized anxiety disorder.

    <p>False</p> Signup and view all the answers

    The Pain Catastrophizing Scale (PCS) evaluates perceptions of pain improvement.

    <p>False</p> Signup and view all the answers

    The St. Michael's Institutional Infusion Protocol uses an intravenous dose of ketamine hydrochloride.

    <p>True</p> Signup and view all the answers

    The study involving standard-care + online CBT and Mindfulness-based Meditation (MM) intervention is funded by the PSI Foundation.

    <p>True</p> Signup and view all the answers

    Ketamine therapy is considered burdensome due to its potent short-term benefits.

    <p>False</p> Signup and view all the answers

    The KAP trial for NeP aims to clarify mechanisms of change regarding chronic pain.

    <p>True</p> Signup and view all the answers

    Psychotherapy synergy with ketamine is expected to have no significant impact on patient outcomes.

    <p>False</p> Signup and view all the answers

    Mindfulness training plays no role in the context of pain management according to the text.

    <p>False</p> Signup and view all the answers

    Study Notes

    Study Protocol Overview

    • Aims to investigate the feasibility and efficacy of ketamine-assisted psychotherapy (KAP) in patients with chronic neuropathic pain
    • Combines ketamine infusions with cognitive-behavioral therapy (CBT) and mindfulness training
    • Recruiting 30 patients with moderate-to-severe neuropathic pain from St. Michael's Hospital's chronic pain clinic

    Ketamine-Assisted Psychotherapy (KAP)

    • KAP combines ketamine infusions with psychotherapy to enhance analgesic effects and promote durable pain relief
    • Ketamine is a rapid-acting antidepressant and pain reliever that acts on NMDA receptors
    • Concurrent psychotherapy can enhance the durability of ketamine's analgesic effects

    Study Design

    • Participants will receive 12 weeks of treatment, including 3 ketamine infusions and 16 hours of phone-based CBT and mindfulness training
    • Primary outcome measures include pain intensity, physical functioning, and emotional functioning
    • Feasibility measures will assess recruitment rate, intervention adherence, patient withdrawal, and missing data

    Patient Population

    • Inclusion criteria: age 18 years and older, moderate-to-severe neuropathic pain, and a clinical diagnosis of neuropathic pain
    • Exclusion criteria: pregnancy, psychiatric disorders, substance use disorder, poorly managed hypertension, and severe liver dysfunction

    Outcome Measures

    • Pain intensity: measured using the Numeric Rating Scale (NRS) and the Patient Global Impression of Change (PGIC) scale
    • Physical functioning: measured using the PROMIS Pain Interference – Short Form v1.1
    • Emotional functioning: measured using the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder 7-item (GAD-7) scale

    Feasibility and Future Directions

    • The study aims to determine the feasibility of conducting a larger definitive trial
    • Results will inform the design of a larger trial and address the need for multidisciplinary pain management in Canada

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    Related Documents

    Ketamine Treatment -- RCT (2).pdf

    Description

    Explore the impact of cognitive-behavioral therapy and mindfulness training on chronic pain patients during and after medical infusions. The study involved 30 participants recruited from St. Michael's Hospital's chronic pain clinic, with a focus on cognitive flexibility, pain-gate closure, and reducing negative reactivity.

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