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Questions and Answers
What type of tissue primarily makes up the bones?
What type of tissue primarily makes up the bones?
Connective tissue.
Identify two functions of bones.
Identify two functions of bones.
Support and protection.
What are 'sesamoid bones' and provide an example.
What are 'sesamoid bones' and provide an example.
Bones that develop within tendons; the patella is an example.
What role do bones play in mineral storage?
What role do bones play in mineral storage?
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Explain the term 'pneumatized bones'.
Explain the term 'pneumatized bones'.
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How do bones contribute to movement?
How do bones contribute to movement?
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What is the function of osteocalcin?
What is the function of osteocalcin?
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Define 'flat bones' and give two examples.
Define 'flat bones' and give two examples.
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What are irregular bones, and where are they typically found?
What are irregular bones, and where are they typically found?
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What tissue types are present in bones, and why are they crucial?
What tissue types are present in bones, and why are they crucial?
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What is the primary role of osteoclasts in bone formation?
What is the primary role of osteoclasts in bone formation?
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Describe the process of endochondral ossification.
Describe the process of endochondral ossification.
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What differentiates intramembranous ossification from endochondral ossification?
What differentiates intramembranous ossification from endochondral ossification?
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Explain the significance of the epiphyseal plate in bone growth.
Explain the significance of the epiphyseal plate in bone growth.
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What role do periosteal cells play in the growth of bone thickness?
What role do periosteal cells play in the growth of bone thickness?
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How do osteoblasts contribute to the formation of new bone tissue?
How do osteoblasts contribute to the formation of new bone tissue?
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What happens to chondrocytes during the process of calcification in bone growth?
What happens to chondrocytes during the process of calcification in bone growth?
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What is the endosteum and its relevance to bone growth?
What is the endosteum and its relevance to bone growth?
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What are the three major types of cartilage and where is each typically found?
What are the three major types of cartilage and where is each typically found?
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How do bones function as organs in the human body?
How do bones function as organs in the human body?
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List the four classifications of bones by shape and provide an example for each.
List the four classifications of bones by shape and provide an example for each.
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What are the main components of the extracellular matrix in bone tissue?
What are the main components of the extracellular matrix in bone tissue?
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Differentiate between intramembranous and endochondral ossification.
Differentiate between intramembranous and endochondral ossification.
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Describe the gross anatomy of a typical long bone.
Describe the gross anatomy of a typical long bone.
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What role do compression lines and tension lines play in bone structure?
What role do compression lines and tension lines play in bone structure?
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Identify the two main divisions of the human skeleton and provide examples of bones from each.
Identify the two main divisions of the human skeleton and provide examples of bones from each.
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What composes the perichondrium and what is its function in cartilage?
What composes the perichondrium and what is its function in cartilage?
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How does fibrocartilage differ from hyaline cartilage in structure and function?
How does fibrocartilage differ from hyaline cartilage in structure and function?
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What is the primary mineral component of the extracellular matrix in bone tissue?
What is the primary mineral component of the extracellular matrix in bone tissue?
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How do osteoblasts contribute to bone formation?
How do osteoblasts contribute to bone formation?
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Which type of bone cells are primarily involved in the resorption process?
Which type of bone cells are primarily involved in the resorption process?
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What role does spongy bone play in the skeletal system?
What role does spongy bone play in the skeletal system?
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Describe the structure of compact bone in terms of its organization.
Describe the structure of compact bone in terms of its organization.
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What are the two layers of the periosteum?
What are the two layers of the periosteum?
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What is the primary function of osteocytes in bone tissue?
What is the primary function of osteocytes in bone tissue?
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Explain the role of collagen fibers in the bone matrix.
Explain the role of collagen fibers in the bone matrix.
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What distinguishes trabecular bone from cortical bone?
What distinguishes trabecular bone from cortical bone?
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What types of cells are osteogenic cells and where are they found?
What types of cells are osteogenic cells and where are they found?
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What are the four primary functions of the periosteum?
What are the four primary functions of the periosteum?
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How does the endosteum contribute to bone dynamics?
How does the endosteum contribute to bone dynamics?
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Describe the blood supply to the diaphysis of a long bone.
Describe the blood supply to the diaphysis of a long bone.
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What is the significance of the arrangement of compact and spongy bone concerning stress forces?
What is the significance of the arrangement of compact and spongy bone concerning stress forces?
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What role do surface markings on bones play in relation to tendons and ligaments?
What role do surface markings on bones play in relation to tendons and ligaments?
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Study Notes
Cartilage
- Connective tissue with collagen and/or elastic fibers in a gel-like structure.
- Chondrocytes (cells) are located in lacunae (cavities).
- Cartilage lacks nerves and blood vessels.
- Some cartilage is surrounded by perichondrium, a connective tissue layer that supports the cartilage.
Types of Cartilage
- Hyaline: Most common type; fine fibers in a gel-like matrix; found in most articulations (e.g., most joints).
- Fibrocartilage: Large bundles of collagen; resists compression and tension forces (e.g., anulus fibrosus).
- Elastic: Matrix of elastic fibers; provides flexibility (e.g., epiglottis).
Bones as Organs
- Composed of connective tissue (bone, cartilage, adipose, blood), epithelial tissue, nervous tissue, and blood vessels.
- Major functions of bones:
- Support: Framework for the body, supporting weight and attachment for soft tissues.
- Movement: Leverage system with muscles to produce movement.
- Protection: Protects vital organs (e.g., skull, rib cage, vertebral column, pelvis).
- Mineral Storage: Stores calcium and phosphate, which can be released into the bloodstream.
- Blood Cell Production and Energy Storage: Red marrow produces red and white blood cells.
- Energy Metabolism: Osteocalcin, a hormone produced by osteoblasts, influences bone production, fat storage, and stimulates insulin production.
Types of Bones
- Flat bones: Thin layers of compact bone surrounding spongy bone (diploë). Examples: roof of skull, ribs, sternum, scapula.
- Sutural bones: Oddly shaped bones inserted between flat bones of the skull. Structurally, these are flat bones.
- Pneumatized bones: Hollow bones or containing air pockets. Example: ethmoid.
- Long bones: Elongated shape. Examples: limbs, fingers, toes.
- Short bones: Roughly cuboidal shape. Examples: carpals, tarsals.
- Sesamoid bones: Present within tendons. Example: patella.
- Irregular bones: Shape varies. Examples: vertebrae, some facial bones, heel bone.
Bone Formation
- Endochondral Ossification: Mesenchymal cells differentiate into osteoblasts, chondrocytes, and osteoclasts.
- Intramembranous Ossification: Osteoblasts differentiate within mesenchymal or fibrous connective tissue (also called dermis ossification); occurs in deeper layers of the dermis. Results in dermal bones. Examples: flat bones of the skull, facial bones, mandible, medial part of clavicle.
Bone Growth
-
Length: Occurs at the epiphyseal plate.
- Chondrocytes divide and form columns.
- Chondrocytes enlarge and produce a calcified matrix.
- Chondrocytes die because the matrix has calcified.
- Osteoclasts dissolve the calcified cartilage, and osteoblasts and blood vessels from the diaphysis invade the area to form new bone.
- After adolescence, the epiphyseal plate becomes ossified, stopping growth.
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Thickness (Appositional Growth): Occurs at the periosteum.
- Periosteal cells differentiate into osteoblasts and produce bone matrix, creating ridges around blood vessels.
- Ridges grow and fuse, forming a canal surrounding the blood vessel. The periosteum becomes endosteum.
- Osteoblasts of the new endosteum form lamellae, closing the canal.
- A new osteon is formed, and new circumferential lamellae are formed, creating new ridges.
Anatomy of a Long Bone
- Epiphysis: Enlarged ends of the bone covered in hyaline cartilage.
- Diaphysis: Shaft of the bone.
- Metaphysis: Region between the epiphysis and diaphysis.
- Periosteum: Tough, fibrous membrane that covers bone.
- Endosteum: Thin membrane that lines the medullary cavity of the bone.
- Medullary Cavity: Hollow space in the diaphysis of the bone filled with red marrow in children and yellow marrow in adults.
Structure of Short, Irregular, and Flat Bones
- Compact Bone: External layers of compact bone covered by periosteum (internal and external tables).
- Spongy Bone (Diploë): Internal layer of spongy bone covered by endosteum.
- Bone Marrow: Present but not in a distinct marrow cavity.
Composition of Bone Tissue
- Extracellular matrix: 15% water, 30% collagen fibers, 55% minerals.
- Collagen fibers provide elasticity.
- Mineral salts (hydroxyapatite, calcium phosphate, magnesium, fluoride, potassium, sulfate) provide rigidity.
- Bone cells:
- Osteogenic (osteoprogenitor) cells: Unspecialized bone cells; only bone cells that divide; found in the inner and outer lining of bones (endosteum and periosteum).
- Osteoblasts: Bone-building cells; secrete collagen fibers and initiate calcification; become osteocytes when surrounded by matrix (osteogenesis).
- Osteocytes: Main cells in healthy bone; involved in maintenance and metabolism.
- Osteoclasts: Derived from white blood cells; concentrated in the endosteum; active in bone growth, remodeling, and resorption (which regulates calcium levels).
Compact Bone
- Forms the outer cortex of bone, providing strength and support.
- Consists of osteons (Haversian systems):
- Lamellae: Concentric rings of bone matrix.
- Canaliculi: Tiny canals connecting lacunae.
- Central canal: Contains blood vessels and nerves.
- Osteocytes: Bone cells located in lacunae.
Spongy Bone
- Found internally, reducing the weight of bone.
- Consists of trabeculae (thin bony plates) that support and protect red bone marrow.
- Osteocytes in lacunae receive nutrients from blood vessels of the endosteum by diffusion.
Periosteum and Endosteum
- Periosteum: Outer fibrous layer of bone; important for attachment of muscles, tendons, ligaments; and for nutrient delivery.
- Endosteum: Single layer of osteoprogenitor cells that lines the medullary cavity and central canals of osteons; active in bone growth and remodeling.
Blood and Nerve Supply
- Diaphysis: Contains the nutrient foramen (entry point for the nutrient artery and exit point for the nutrient vein).
- Epiphysis and Metaphysis: Numerous veins and arteries penetrate through foramina.
- Periosteum: Numerous small blood vessels branch from the nutrient artery and vein.
- Nerve supply: Follows veins and arteries; sensory nerves; abundant nerve endings in the periosteum and cortical bone make fractures painful.
Forces at Work
- The structural arrangement of bone tissue reflects the forces it encounters.
- Compact bone is thicker where forces are greater, and the mesh of spongy bone is oriented to counteract stress.
- Spongy bone is more appropriate for multidirectional tension.
- Bones undergo constant remodeling throughout life, adapting to changing forces.
Bone Surface Markings
- Develop as anchor points for tendons and ligaments as muscles are used (tension and compression forces modify topography).
- Some markings allow passage of nerves and blood vessels and are present from birth.
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Test your knowledge on cartilage types and bone functions. This quiz covers the characteristics of different cartilage, including hyaline, fibrocartilage, and elastic cartilage. Understand how bones serve as organs in the human body.