Podcast
Questions and Answers
What is the significance of elevated CK-MB levels above 5% MB in a patient?
What is the significance of elevated CK-MB levels above 5% MB in a patient?
It can indicate myocardial infarction.
What might be a reason for elevated cTnT levels in the absence of acute coronary syndrome?
What might be a reason for elevated cTnT levels in the absence of acute coronary syndrome?
Chronic renal failure (CRF).
Why is cTnI considered the most cardiac specific biomarker?
Why is cTnI considered the most cardiac specific biomarker?
Because it is not elevated by chronic renal failure (CRF).
What is the normal range for myoglobin in the blood?
What is the normal range for myoglobin in the blood?
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Which cardiac biomarker has a normal range of < 0.1 ng/ml?
Which cardiac biomarker has a normal range of < 0.1 ng/ml?
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How long does it take for MB-Ck to return to normal levels after it initially elevates?
How long does it take for MB-Ck to return to normal levels after it initially elevates?
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What is the peak time for Troponin T elevation?
What is the peak time for Troponin T elevation?
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For how long can Troponin I levels remain elevated before returning to normal?
For how long can Troponin I levels remain elevated before returning to normal?
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Within what time frame does Lactate dehydrogenase (LDH) initially elevate?
Within what time frame does Lactate dehydrogenase (LDH) initially elevate?
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How long after an AST (SGOT) elevation does it take for it to return to normal?
How long after an AST (SGOT) elevation does it take for it to return to normal?
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Study Notes
Cardiac Enzymes (Biomarkers)
-
CK-MB:
- Normally has less than 5% MB
- Normal level is less than 85 ng/ml
Myoglobin
- Normal level is less than 85 ng/ml
Troponin
-
cTnT:
- Normal level is less than 0.01 ng/ml
- May be elevated in cases of Chronic Renal Failure (CRF)
-
Troponin I:
- Normal level is less than 0.1 ng/ml
- Not elevated in cases of Chronic Renal Failure (CRF)
- Most cardiac specific
Time Course of Cardiac Biomarkers
CK-MB
- Initial elevation occurs between 3-12 hours
- Peaks at 24 hours
- Returns to normal in 2-3 days
Troponin I
- Initial elevation occurs between 3-12 hours
- Peaks at 24 hours
- Returns to normal in 5-10 days
Troponin T
- Initial elevation occurs between 3-12 hours
- Peaks at 12-24 hours
- Returns to normal in 5-14 days
AST (SGOT)
- Initial elevation occurs within a few hours (6-12 hours)
- Peaks at 36 hours
- Returns to normal after 5 days
Lactate Dehydrogenase (LDH)
- Initial elevation occurs within a few hours (6-12 hours)
- Peaks at 3 days
- Returns to normal after 1 week
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Description
This quiz covers the normal values of cardiac enzymes, including CK-MB, Myoglobin, Troponin, cTnT, and Troponin I, which are biomarkers used to diagnose cardiac conditions.
