Podcast
Questions and Answers
What significant life-threatening condition was noted during the first child’s treatment with anti-CD19 CAR T cells?
What significant life-threatening condition was noted during the first child’s treatment with anti-CD19 CAR T cells?
What was the outcome for the first child treated with anti-CD19 CAR T cells in 2012?
What was the outcome for the first child treated with anti-CD19 CAR T cells in 2012?
What has been a significant regulatory milestone following the success of anti-CD19 CAR T cell therapy?
What has been a significant regulatory milestone following the success of anti-CD19 CAR T cell therapy?
What does the ongoing research with CAR T cells suggest about their versatility?
What does the ongoing research with CAR T cells suggest about their versatility?
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In which type of cancers has anti-CD19 CAR T cell therapy shown unprecedented success?
In which type of cancers has anti-CD19 CAR T cell therapy shown unprecedented success?
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Study Notes
CAR T-cell Therapy in Childhood Leukemia
- First child with acute lymphoblastic leukemia (ALL) treated with anti-CD19 CAR T-cells in April 2012
- Experienced a life-threatening cytokine-release syndrome (CRS)
- Remarkable recovery and ongoing remission for over 6 years
- Demonstrated potential for durable remission in CAR T-cell therapy
- Early phase trials showed unprecedented success in treating relapsed and/or refractory CD19-expressing B-cell malignancies
- Many patients achieved long-term remission, potentially cure
- FDA approved two anti-CD19 CAR T-cell products for B-cell ALL and diffuse large B-cell lymphoma
- Revolutionized anticancer immunotherapy
- More than 100 global trials are ongoing using CAR T-cells targeting antigens other than CD19
Types of Leukemia and Lymphoma Treated
- Acute lymphoblastic leukemia (ALL): Targeted in the first child trial and now with FDA-approved treatments
- Chronic lymphocytic leukemia (CLL): Treated previously in adults
- Follicular lymphoma: Successes initially seen in adult trials
- Diffuse large B-cell lymphoma Now also treated with FDA-approved CAR T-cell products
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Description
Explore the groundbreaking use of CAR T-cell therapy in treating childhood leukemia, particularly acute lymphoblastic leukemia. This quiz highlights the first patient treated, the challenges faced, and the enduring successes seen in numerous trials. Learn about the FDA approvals and the potential revolution in immunotherapy for B-cell malignancies.
