CAR T-cell Therapy Toxicities and Management

CD28 induces rapid T cell activation, whereas 4-1BB induces slower T cell activation.

CD28 CAR T cells undergo aerobic glycolysis, whereas 4-1BB CAR T cells undergo oxidative metabolism.

4-1BB CAR T cells persist for up to 5 years, whereas CD28 CAR T cells persist for approximately 3 months.

<p>The extracellular binding domain recognizes and binds to a specific target antigen on tumor cells.</p> Signup and view all the answers

<p>The hinge domain provides flexibility and spacer function between the extracellular binding domain and the transmembrane domain.</p> Signup and view all the answers

<p>CD19 is a specific antigen expressed on B cells, allowing for targeted therapy with minimal off-tumor effects.</p> Signup and view all the answers

<p>The intracellular domain transduces signals to activate T cells and induce effector functions.</p> Signup and view all the answers

<p>4-1BB promotes slower T cell activation, leading to prolonged persistence and reduced toxicity.</p> Signup and view all the answers

<p>The structure of a CAR, including the extracellular binding domain, hinge domain, transmembrane domain, and intracellular domain, determines its ability to target and activate T cells.</p> Signup and view all the answers

<p>Different target antigens can impact the specificity and efficacy of CAR T cell therapy, as well as the risk of off-tumor effects.</p> Signup and view all the answers

<p>CAR T cells can be rapidly expanded and modified, and can target specific tumor antigens, allowing for more targeted therapy.</p> Signup and view all the answers