Podcast
Questions and Answers
A patient undergoing treatment develops cytokine release syndrome (CRS). Which class of therapies is most likely contributing to this adverse effect?
A patient undergoing treatment develops cytokine release syndrome (CRS). Which class of therapies is most likely contributing to this adverse effect?
- Telomerase Inhibitors
- HDAC Inhibitors
- CAR-T Therapies (correct)
- Nuclear Export Inhibitors
A researcher is studying a novel drug that promotes the activation of NK cells by increasing IL-2 and interferon gamma levels. Which of the following drugs shares a similar mechanism of action?
A researcher is studying a novel drug that promotes the activation of NK cells by increasing IL-2 and interferon gamma levels. Which of the following drugs shares a similar mechanism of action?
- Venetoclax
- Thalidomide (correct)
- Acalabrutinib
- Tafasitamab
A patient with acute promyelocytic leukemia (APL) is being treated with a drug that induces differentiation of malignant cells. Which of the following drugs shares this mechanism of action through the degradation of PML-RARα?
A patient with acute promyelocytic leukemia (APL) is being treated with a drug that induces differentiation of malignant cells. Which of the following drugs shares this mechanism of action through the degradation of PML-RARα?
- Asparaginase
- Omacetaxine Mepesuccinate
- Arsenic Trioxide (correct)
- Idelalisib
A researcher aims to inhibit protein synthesis in leukemia cells by targeting ribosomes. Which drug should they select for this experiment?
A researcher aims to inhibit protein synthesis in leukemia cells by targeting ribosomes. Which drug should they select for this experiment?
A scientist is developing a new therapy to induce apoptosis in cancer cells by targeting BCL-2. Which of the following drugs functions through a similar mechanism?
A scientist is developing a new therapy to induce apoptosis in cancer cells by targeting BCL-2. Which of the following drugs functions through a similar mechanism?
A patient undergoing treatment with methoxsalen (Uvadex) should be monitored for potential complications arising from which primary mechanism of action?
A patient undergoing treatment with methoxsalen (Uvadex) should be monitored for potential complications arising from which primary mechanism of action?
In the treatment of acute promyelocytic leukemia (APL), which drug directly influences the PML-RARα fusion protein, thereby promoting differentiation of leukemic cells into normal white blood cells?
In the treatment of acute promyelocytic leukemia (APL), which drug directly influences the PML-RARα fusion protein, thereby promoting differentiation of leukemic cells into normal white blood cells?
Which therapeutic agent selectively binds to and activates retinoid X receptors (RXR), playing a crucial role in modulating cellular differentiation and proliferation pathways?
Which therapeutic agent selectively binds to and activates retinoid X receptors (RXR), playing a crucial role in modulating cellular differentiation and proliferation pathways?
A patient undergoing treatment with tretinoin (ATRA) should be closely monitored for which severe adverse effect, indicative of differentiation syndrome and rapid proliferation of white blood cells?
A patient undergoing treatment with tretinoin (ATRA) should be closely monitored for which severe adverse effect, indicative of differentiation syndrome and rapid proliferation of white blood cells?
Pembrolizumab and nivolumab enhance the body's immune response against cancer cells by disrupting which specific interaction?
Pembrolizumab and nivolumab enhance the body's immune response against cancer cells by disrupting which specific interaction?
Which monoclonal antibody is engineered to specifically target the CD19 protein found on the surface of B-cells, making it a valuable tool in treating certain B-cell lymphomas?
Which monoclonal antibody is engineered to specifically target the CD19 protein found on the surface of B-cells, making it a valuable tool in treating certain B-cell lymphomas?
A patient with relapsed or refractory B-cell lymphoma is being considered for treatment. Which combination of monoclonal antibodies is designed to target the CD20 protein on B-cells, initiating cell death and reducing the tumor burden?
A patient with relapsed or refractory B-cell lymphoma is being considered for treatment. Which combination of monoclonal antibodies is designed to target the CD20 protein on B-cells, initiating cell death and reducing the tumor burden?
Brentuximab vedotin disrupts cellular division by interfering with what key process?
Brentuximab vedotin disrupts cellular division by interfering with what key process?
Quel droga promote le activation de cellulas NK per augmentar le nivellos de IL-2 e interferon gamma?
Quel droga promote le activation de cellulas NK per augmentar le nivellos de IL-2 e interferon gamma?
Qual effecto adverse es plus probabile in patientes tractate con agentes qui bloca le menin e le transcription aberrente?
Qual effecto adverse es plus probabile in patientes tractate con agentes qui bloca le menin e le transcription aberrente?
Qual droga directe-mente degrada PML-RAR-a, inducente differentiation de cellulas leucemic?
Qual droga directe-mente degrada PML-RAR-a, inducente differentiation de cellulas leucemic?
Qual es le objectivo de CD19 pro le therapia CAR-T, con EXCEPTION de un del agentes listate?
Qual es le objectivo de CD19 pro le therapia CAR-T, con EXCEPTION de un del agentes listate?
Qual mechanismo de action es associate con imetelstat?
Qual mechanismo de action es associate con imetelstat?
Which therapeutic approach directly targets the CD38 protein on myeloma cells, leveraging Fc regions to engage NK cells?
Which therapeutic approach directly targets the CD38 protein on myeloma cells, leveraging Fc regions to engage NK cells?
A patient with relapsed multiple myeloma is being considered for a bispecific T-cell engager that targets GPRC5D. Which of the following medications fits this description?
A patient with relapsed multiple myeloma is being considered for a bispecific T-cell engager that targets GPRC5D. Which of the following medications fits this description?
Which drug inhibits the activity of histone deacetylases (HDACs) to treat T-cell lymphomas and multiple myeloma?
Which drug inhibits the activity of histone deacetylases (HDACs) to treat T-cell lymphomas and multiple myeloma?
Which of the following drugs is designed to inhibit the Menin-MLL interaction, which is crucial for KMT2A-rearranged leukemias?
Which of the following drugs is designed to inhibit the Menin-MLL interaction, which is crucial for KMT2A-rearranged leukemias?
Which drug is used in the treatment of acute myeloid leukemia (AML) by targeting mutant IDH1 or IDH2 enzymes?
Which drug is used in the treatment of acute myeloid leukemia (AML) by targeting mutant IDH1 or IDH2 enzymes?
A patient with chronic lymphocytic leukemia (CLL) has developed resistance to traditional therapies. Which drug, targeting BCL-2, might be considered to induce apoptosis in these resistant cancer cells?
A patient with chronic lymphocytic leukemia (CLL) has developed resistance to traditional therapies. Which drug, targeting BCL-2, might be considered to induce apoptosis in these resistant cancer cells?
Which cellular therapy targets the BCMA protein on multiple myeloma cells?
Which cellular therapy targets the BCMA protein on multiple myeloma cells?
Which drug is designed to inhibit the exportin 1 (XPO1) protein, leading to the accumulation of tumor suppressor proteins in the nucleus?
Which drug is designed to inhibit the exportin 1 (XPO1) protein, leading to the accumulation of tumor suppressor proteins in the nucleus?
Qual es le consequentia immediate de blocar le interaction inter PD-1 e su ligando in le therapia de cancere?
Qual es le consequentia immediate de blocar le interaction inter PD-1 e su ligando in le therapia de cancere?
Qual scopo specific ha le anticorpore monoclonal obinutuzumab in le therapia de lymphoma?
Qual scopo specific ha le anticorpore monoclonal obinutuzumab in le therapia de lymphoma?
Qual es le mechanismo de action primari de brentuximab vedotin in le tractamento de lymphoma?
Qual es le mechanismo de action primari de brentuximab vedotin in le tractamento de lymphoma?
Qual therapia es plus probabile causar le syndrome de release de cytokines (CRS) per su mechanismo de action?
Qual therapia es plus probabile causar le syndrome de release de cytokines (CRS) per su mechanismo de action?
Qual scopo molecular ha le administration de glasdegib in certe tractamentos de cancere?
Qual scopo molecular ha le administration de glasdegib in certe tractamentos de cancere?
Qual mechanismo differentia asciminib ab altere STIs que ciba le cromosoma Philadelphia (Ph)?
Qual mechanismo differentia asciminib ab altere STIs que ciba le cromosoma Philadelphia (Ph)?
Qual consequentia es plus probabile que resultara de un tractamento con brentuximab vedotin que affice le polymerisation de tubulina?
Qual consequentia es plus probabile que resultara de un tractamento con brentuximab vedotin que affice le polymerisation de tubulina?
Qual mechanismo de action define omacetaxine mepesuccinat in le therapia de cancere?
Qual mechanismo de action define omacetaxine mepesuccinat in le therapia de cancere?
Flashcards
Idelalisib
Idelalisib
A drug that inhibits the PI3K pathway, used in certain leukemias.
Venetoclax
Venetoclax
A BCL-2 inhibitor used to treat chronic lymphocytic leukemia (CLL).
Omacetaxine mepesuccinate
Omacetaxine mepesuccinate
Inhibits protein synthesis by binding ribosomes, used in leukemia.
Romidepsin
Romidepsin
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Cytokine release syndrome (CRS)
Cytokine release syndrome (CRS)
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Methoxsalen (Uvadex) action
Methoxsalen (Uvadex) action
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Tretinoin (ATRA) function
Tretinoin (ATRA) function
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Bexarotene activity
Bexarotene activity
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Tretinoin major side effect
Tretinoin major side effect
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Pembrolizumab/Nivolumab mechanism
Pembrolizumab/Nivolumab mechanism
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Tafasitamab target
Tafasitamab target
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FLT3 inhibitor example
FLT3 inhibitor example
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Blinatumomab targets
Blinatumomab targets
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Mutant IDH Blockers
Mutant IDH Blockers
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Inhibit Telomerase
Inhibit Telomerase
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CAR-T Therapy
CAR-T Therapy
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Hydroxyurea
Hydroxyurea
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Thalidomide function
Thalidomide function
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Photodynamic therapy
Photodynamic therapy
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Retinoids
Retinoids
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PD-1 Inhibitors
PD-1 Inhibitors
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Anti-CD19 mAbs
Anti-CD19 mAbs
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Anti-CD22 mAbs
Anti-CD22 mAbs
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BITE antibodies
BITE antibodies
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Proteasome inhibitors
Proteasome inhibitors
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BCL-2 Blockers
BCL-2 Blockers
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Multiple Myeloma
Multiple Myeloma
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B-cell Lymphoma
B-cell Lymphoma
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CD19 Targeting
CD19 Targeting
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BCMA Targeting
BCMA Targeting
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Imatinib Use
Imatinib Use
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Venetoclax Mechanism
Venetoclax Mechanism
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CAR-T Cells
CAR-T Cells
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FLT3 Mutation Targeting
FLT3 Mutation Targeting
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Study Notes
Methoxsalen (Uvadex) Mechanism of Action
- Inhibits DNA synthesis and damages DNA
PML-RAR Activation Drug
- Tretinoin (ATRA) activates PML-RAR to inhibit differentiation and increase normal white blood cell (WBC) production.
RXR Receptor Activator
- Bexarotene activates RXR receptors.
Tretinoin (ATRA) Side Effect
- A major side effect of tretinoin (ATRA) is RA-APL syndrome and leukocytosis.
Pembrolizumab and Nivolumab Action
- These drugs block the inhibition of T-cells via PD-1.
CD19 Targeting Monoclonal Antibody
- Tafasitamab targets CD19.
CD20 Targeting Monoclonal Antibodies
- Rituximab, ofatumumab, and obinutuzumab target CD20.
Tubulin Polymerization Inhibitor
- Brentuximab vedotin inhibits tubulin polymerization.
SLAMF Targeting Drug
- Elotuzumab targets SLAMF and increases natural killer (NK) cells.
Blinatumomab and Mosunetuzumab Targets
- Blinatumomab and mosunetuzumab target CD3 and CD19.
JAK Inhibitors
- Fedratinib, pacritinib, ruxolitinib, are JAK inhibitors.
BTK Inhibitors
- Ibrutinib, acalabrutinib, and zanubrutinib are BTK inhibitors.
SMO Signaling Inhibitor
- Glasdegib specifically blocks SMO signaling.
FLT3 Inhibitor
- Midostaurin is an FLT3 inhibitor.
PI3K Inhibitor
- Idelalisib, duvelisib, alpelisib, and inavolisib are PI3K inhibitors.
Protein Synthesis Inhibitor
- Omacetaxine mepesuccinate inhibits protein synthesis by binding to ribosomes.
HDAC Inhibitor
- Romidepsin, vorinostat, belinostat, and panobinostat are HDAC inhibitors.
HMT Inhibitor
- Tazemetostat inhibits HMT.
Nuclear Export Inhibitor
- Selinexor is a nuclear export inhibitor.
Telomerase Inhibitor
- Imetelstat inhibits telomerase.
Differentiation Syndrome Drug
- Ivosidenib, enasidnib, and olutasidenib are associated with differentiation syndrome.
Asparagine Depleting Drug
- Asparaginase depletes asparagine from plasma.
PML-RAR Degradation Effect
- Arsenic trioxide degrades PML-RARα, leading to differentiation.
NK Cell Activator
- Thalidomide increases IL-2 and interferon gamma to activate NK cells.
BCMA Targeting CAR-T Therapy
- Idecabtagene vicleucel targets BCMA.
CAR-T Therapy Side Effect
- Cytokine release syndrome (CRS) is a severe adverse effect of CAR-T therapies.
BCL2 Inhibitor
- Venetoclax is a BCL2 inhibitor
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Description
Explore the mechanisms of action and key targets of cancer immunotherapy drugs. Learn about T-cell inhibition blockers, monoclonal antibodies targeting CD19 and CD20, tubulin polymerization inhibitors, and drugs targeting SLAMF. Also covered are Blinatumomab, Mosunetuzumab, and JAK inhibitors.
