18 Questions
Which of the following drugs is a monoclonal antibody used for treating cancer?
Bevacizumab
What is the general form in which monoclonal antibodies can be formulated?
Lyophilized forms
Which of the following monoclonal antibodies is used for treating B-cell non-Hodgkin lymphoma?
Rituxan
Which drug is not a monoclonal antibody?
Gemtuzumab ozogamicin
What is the primary target of Panitumumab, a monoclonal antibody used for cancer treatment?
EGFR protein
In what form can monoclonal antibodies be administered as part of cancer treatment?
Subcutaneous injection
What is the third stage of lyophilization?
Secondary drying
What is the primary role of stabilizers in lyophilization?
To prevent denaturation of proteins and maintain their stability
Which factor distinguishes the secondary drying stage from the primary drying stage?
Temperature in the drying chamber
What is the main function of cryoprotectants in lyophilization?
To prevent protein denaturation during freezing
Which component is primarily responsible for maintaining the pH within a certain range during lyophilization?
Buffers
In which stage does the formation of ice crystals occur in lyophilization?
Freezing the solution
Which factor does NOT contribute to potential protein denaturation during lyophilization?
Presence of stabilizers
What is the main purpose of bulking agents in lyophilized formulations?
To improve flow properties of the final product
What is one role of saccharides as stabilizers in lyophilization?
To protect proteins from oxidation and reduction reactions
How do stabilizers help mitigate stress during lyophilization?
By maintaining protein stability and preventing denaturation
What distinguishes cryoprotectants from bulking agents in lyophilization?
Cryoprotectants decrease vapor pressure during primary drying, while bulking agents do not.
In what way do bulking agents contribute to improving lyophilized formulations?
By improving flow properties of the final product
Explore the important monoclonal antibodies used as cancer drugs, including OrthoClone OKT3, Rituxan, Alemtuzumab, Trastuzumab, Panitumumab, Bevacizumab, Ibritumomab tiuxetan, Tositumomab, and Gemtuzumab ozogamicin. Learn about their applications and significance in cancer treatment.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
