Monoclonal Antibodies and Cancer Drugs

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Questions and Answers

Which of the following drugs is a monoclonal antibody used for treating cancer?

  • Alemtuzumab
  • Bevacizumab (correct)
  • OrthoClone OKT3
  • Rituxan

What is the general form in which monoclonal antibodies can be formulated?

  • Powder for inhalation
  • Liquid solution for oral administration
  • Lyophilized forms (correct)
  • Gel capsules

Which of the following monoclonal antibodies is used for treating B-cell non-Hodgkin lymphoma?

  • Rituxan (correct)
  • Bevacizumab
  • Panitumumab
  • Trastuzumab

Which drug is not a monoclonal antibody?

<p>Gemtuzumab ozogamicin (D)</p> Signup and view all the answers

What is the primary target of Panitumumab, a monoclonal antibody used for cancer treatment?

<p>EGFR protein (C)</p> Signup and view all the answers

In what form can monoclonal antibodies be administered as part of cancer treatment?

<p>Subcutaneous injection (C)</p> Signup and view all the answers

What is the third stage of lyophilization?

<p>Secondary drying (A)</p> Signup and view all the answers

What is the primary role of stabilizers in lyophilization?

<p>To prevent denaturation of proteins and maintain their stability (B)</p> Signup and view all the answers

Which factor distinguishes the secondary drying stage from the primary drying stage?

<p>Temperature in the drying chamber (B)</p> Signup and view all the answers

What is the main function of cryoprotectants in lyophilization?

<p>To prevent protein denaturation during freezing (C)</p> Signup and view all the answers

Which component is primarily responsible for maintaining the pH within a certain range during lyophilization?

<p>Buffers (B)</p> Signup and view all the answers

In which stage does the formation of ice crystals occur in lyophilization?

<p>Freezing the solution (D)</p> Signup and view all the answers

Which factor does NOT contribute to potential protein denaturation during lyophilization?

<p>Presence of stabilizers (B)</p> Signup and view all the answers

What is the main purpose of bulking agents in lyophilized formulations?

<p>To improve flow properties of the final product (A)</p> Signup and view all the answers

What is one role of saccharides as stabilizers in lyophilization?

<p>To protect proteins from oxidation and reduction reactions (C)</p> Signup and view all the answers

How do stabilizers help mitigate stress during lyophilization?

<p>By maintaining protein stability and preventing denaturation (A)</p> Signup and view all the answers

What distinguishes cryoprotectants from bulking agents in lyophilization?

<p>Cryoprotectants decrease vapor pressure during primary drying, while bulking agents do not. (A)</p> Signup and view all the answers

In what way do bulking agents contribute to improving lyophilized formulations?

<p>By improving flow properties of the final product (C)</p> Signup and view all the answers

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