Cancer Biology Quiz
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Questions and Answers

Which of the following is a characteristic of cancer cells?

  • Increased cell adhesion
  • Sensitivity to external growth signals
  • Loss of contact inhibition (correct)
  • Reduced genetic instability
  • Leukemia is a type of solid tumor.

    False (B)

    What is the term used for a malignant growth with atypical cells in epithelial tissue that has not yet invaded local tissue?

    Carcinoma in situ

    The process of a cancer cell spreading from its original site to other parts of the body is called ______.

    <p>metastasis</p> Signup and view all the answers

    Match the following terms with their respective descriptions:

    <p>Carcinoma = Cancer arising from epithelial cells Sarcoma = Cancer arising from connective tissues Lymphoma = Cancer affecting lymphatic tissue Leukemia = Cancer of blood-forming cells</p> Signup and view all the answers

    Which of the following cancers is NOT a carcinoma?

    <p>Osteosarcoma (C)</p> Signup and view all the answers

    Normal cells have mechanisms to correct mutations that occur in their DNA.

    <p>True (A)</p> Signup and view all the answers

    Describe one way in which cancer cells can become independent of external growth signals.

    <p>Cancer cells can become independent of external growth signals by producing their own growth factors, making them less reliant on external stimulation.</p> Signup and view all the answers

    Cancer cells are able to evade the immune system by producing unusual antigens.

    <p>True (A)</p> Signup and view all the answers

    The enzyme ____ helps cancer cells to maintain their telomere length, allowing them to divide indefinitely.

    <p>telomerase</p> Signup and view all the answers

    Explain why cancer cells often rely heavily on anaerobic respiration.

    <p>Cancer cells divide rapidly and require a lot of building blocks for new cell construction. They often reside in anoxic environments and therefore rely on anaerobic respiration to generate energy, even in the presence of oxygen.</p> Signup and view all the answers

    Match the following terms with their corresponding descriptions:

    <p>Anchorage dependence = Normal cells require attachment to a surface to grow and divide Contact inhibition = Normal cells stop dividing when they come into contact with other cells Telomerase = An enzyme that helps cancer cells maintain telomere length Anaerobic respiration = Metabolic process used by cancer cells in low-oxygen environments to generate energy Unusual antigens = Markers produced by cancer cells that can be recognized by the immune system</p> Signup and view all the answers

    Which of these is NOT a precaution taken during surgery for localized tumors?

    <p>Determining the age of the tumor (D)</p> Signup and view all the answers

    Surgery is never used prophylactically in cancer treatment.

    <p>False (B)</p> Signup and view all the answers

    What are the two main types of cancer that children are more likely to develop compared to adults?

    <p>Leukemia and brain tumors</p> Signup and view all the answers

    Childhood cancers are often diagnosed during periods of rapid ______ and maturation.

    <p>growth</p> Signup and view all the answers

    Match the following factors to their potential association with childhood cancer:

    <p>Down syndrome = Increased susceptibility to acute lymphoblastic leukemia Pre-natal exposure to drugs = Potential childhood cancer risk factor Childhood exposure to ionizing radiation = Potential childhood cancer risk factor Genetic risk factors = Potential childhood cancer risk factor unknown causes = Majority of childhood cancer cases</p> Signup and view all the answers

    Which of the following countries has a higher rate of colon cancer among their populations in the United States?

    <p>U.S. families (B)</p> Signup and view all the answers

    According to the provided information, heredity plays a significant role in the development of all types of cancer, with inherited factors accounting for the majority of cancer cases.

    <p>False (B)</p> Signup and view all the answers

    What is the relationship between meat consumption and colon cancer rates as shown in the graph?

    <p>The graph shows a positive correlation between meat consumption and colon cancer rates. As meat consumption increases, the number of cases of colon cancer per 100,000 people also increases. This suggests that a higher intake of meat may be associated with an increased risk of colon cancer.</p> Signup and view all the answers

    According to the article, only about ______% of all cancers are linked to heritable factors.

    <p>10-20</p> Signup and view all the answers

    Match the following types of cancer with the corresponding possible contributing factors listed:

    <p>Colon cancer = High meat consumption Stomach cancer = Unknown, but possibly related to dietary habits Breast cancer = Inherited factors, such as BRCA1/BRCA2 mutations</p> Signup and view all the answers

    Which of the following is a defining characteristic of cancer?

    <p>All of the above (D)</p> Signup and view all the answers

    Metastasis makes cancer treatment more challenging.

    <p>True (A)</p> Signup and view all the answers

    What is the name of the first lymph node that drains a particular area, where metastatic cancer cells may lodge?

    <p>Sentinel node</p> Signup and view all the answers

    Cancer cells spread through the ______ system.

    <p>lymphatic</p> Signup and view all the answers

    Match the following types of cancer with their primary mode of metastasis:

    <p>Carcinomas = Bloodstream Sarcomas = Lymphatic system Leukemia = Bloodstream Lymphoma = Lymphatic system</p> Signup and view all the answers

    Benign tumors spread through the lymphatic system.

    <p>False (B)</p> Signup and view all the answers

    What is the name of the process by which cancer cells induce the growth of new blood vessels into the tumor?

    <p>Neoangiogenesis</p> Signup and view all the answers

    Which of the following mechanisms contributes to cancer cell evasion of the innate immune system?

    <p>Both A and B (D)</p> Signup and view all the answers

    Inflammation and cancer share a common mechanism of cell growth stimulation and blood vessel development.

    <p>True (A)</p> Signup and view all the answers

    Which of the following viruses is strongly associated with cervical cancer?

    <p>Human Papillomavirus (HPV) (D)</p> Signup and view all the answers

    Chronic infection with _ has been linked to gastric carcinoma.

    <p>Helicobacter pylori</p> Signup and view all the answers

    What is the primary mechanism by which viruses can contribute to cancer development?

    <p>Viruses can integrate their genetic material into the host cell's DNA, potentially activating proto-oncogenes or disrupting tumor suppressor genes.</p> Signup and view all the answers

    Which of the following environmental factors has been linked to increased cancer risk?

    <p>Exposure to pesticides (B)</p> Signup and view all the answers

    Epigenetics refers to changes in the sequence of DNA itself, not the genes.

    <p>False (B)</p> Signup and view all the answers

    Match each cancer type with the region of highest incidence:

    <p>Lung Cancer = U.K. Stomach Cancer = Japan Colon Cancer = US Liver Cancer = China Cervical Cancer = Brazil Skin Cancer = Australia</p> Signup and view all the answers

    Explain how the development of a virus-related cancer differs from a cancer caused by environmental factors.

    <p>Virus-related cancers often involve viral integration into the host cell's DNA, directly altering the genetic code. Environmental factors can induce DNA damage or epigenetic changes, leading to altered gene expression.</p> Signup and view all the answers

    Heredity plays a major role in causing all types of cancer.

    <p>False (B)</p> Signup and view all the answers

    The _ of the population may be infected with EBV, but only a small percentage develop EBV-related cancer.

    <p>majority</p> Signup and view all the answers

    Flashcards

    Lymphomas

    Cancers originating from lymphatic tissue.

    Leukemias

    Cancers of blood-forming cells.

    Solid tumors

    Tumors initially confined to specific tissues or organs.

    Hematologic tumors

    Cancers from cells normally found in blood or lymph.

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    Carcinoma in situ

    Malignant characteristics in epithelium, not invaded yet.

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    Genetic instability

    High mutation frequency in cancer cells.

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    Loss of contact inhibition

    Cancer cells continue to grow upon touching each other.

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    Decrease in cell adhesion

    Cancer cells have lower ability to stick together and can spread.

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    Metastasis

    The spread of cancer cells from the original site to distant organs.

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    Local Spread

    Cancer cells invade surrounding tissue using enzymes that break down cells and connective tissue.

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    Distant Spread

    Cancer cells invade through lymph and blood vessels to spread to other organs.

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    Sentinel Node

    The initial lymph node that drains a cancerous area, indicating possible metastasis.

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    Carcinomas vs. Sarcomas

    Carcinomas spread through lymphatics; sarcomas spread through blood vessels.

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    Proteolytic Enzymes

    Enzymes secreted by cancer cells to invade tissues from blood vessels.

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    Immune Evasion

    Cancer cells evade the immune system by mimicking normal cells, often coating themselves.

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    Lymphangiogenesis & Neoangiogenesis

    Growth of new lymph and blood vessels that aids tumor survival and spread.

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    Anchorage Dependence

    Normal epithelial cells die without attachment to extracellular matrix; cancer cells survive regardless.

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    Unusual Antigens

    Surface markers made by cancer cells not produced by their tissue of origin, recognized as foreign.

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    Immortal Cells

    Cancer cells divide without limit due to the action of telomerase which maintains telomeres.

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    Telomeres

    Sections at the ends of chromosomes that shorten with each division, limiting normal cell replication.

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    Altered Metabolism

    Cancer cells favor anaerobic respiration for rapid growth and energy needs, even in oxygen presence.

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    Anaerobic Respiration

    Energy production process used by cancer cells primarily through glycolysis, resulting in less ATP.

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    Contact Inhibition

    Normal cells stop growing when they touch other cells; cancer cells ignore this and pile up.

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    Glucose Uptake in Cancer

    Cancer cells consume more glucose for energy and building blocks due to rapid division.

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    Surgery for localized tumors

    A treatment option that aims to remove localized tumors, may also be used preventively in at-risk patients.

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    Colon Cancer Rates

    Occurrences of colon cancer measured per 100,000 people.

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    Childhood cancer types

    Different types than adults, including leukemia, brain tumors, and sarcomas, which are fast-growing cancers.

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    Meat Consumption

    Consumption of meat linked to colon cancer rates differences by country.

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    Genetic risk factors

    Certain genetics, like Down syndrome, increase susceptibility to specific cancers in children.

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    Inherited Factors in Cancer

    Genetic factors like BRCA1/BRCA2 influencing cancer risk.

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    Chemotherapy in children

    Widely used for treatment, because children often tolerate it better and cancers respond well to it.

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    Proportion of Patients

    Percentage of women with BRCA mutations developing breast cancer by age.

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    Carcinogens in Workplace

    Substances in work environments that can cause cancer.

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    Long-term effects of cancer treatment

    Potential risks include physical and mental impairments, and increased cancer risk later in life.

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    Inflammation and cancer coexist

    Both involve the migration of immune cells and the release of growth factors.

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    Viruses associated with cancer

    Certain viruses alter DNA or cause inflammation, leading to cancer. Example: HPV and cervical cancer.

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    Chronic Hepatitis and cancer

    Up to 80% of liver cancer cases are linked to chronic HBV or HCV infections.

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    EBV and B cell lymphomas

    EBV infection can lead to lymphomas if the person is immunosuppressed.

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    Helicobacter pylori and gastric cancer

    Chronic infection with H. pylori is linked to gastric carcinoma.

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    Environmental/lifestyle factors

    Certain habits like smoking and poor diets can increase cancer risk.

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    Carcinogen interactions

    Environmental factors may influence gene expression rather than mutate genes.

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    Epidemiological studies

    Population studies show links between certain regions and cancer types.

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    Cancers from inheritance

    Some cancers have hereditary components, emphasizing genetic risk.

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    Cancer resistance variability

    Not everyone with cancer-causing agents develops cancer; individual resistance varies.

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    Study Notes

    Neoplasms

    • Neoplasm is a new growth, a tumor
    • Two types: benign and malignant (cancer)

    Benign Tumors

    • Have lost ability to control proliferation, but growth is slow
    • Made of well-differentiated cells and organized stroma
    • Do not invade beyond their capsule
    • Do not metastasize
    • Named for the tissue of origin with the suffix "oma"
    • Lipoma – benign tumor of fat cells
    • Can still cause problems if growth interferes with surrounding tissue function (e.g., compression of brain tissue, or inappropriate hormone production)

    Malignant Tumors (Cancer)

    • More rapid growth rate
    • Loss of differentiation (anaplasia) – cells are pleomorphic (different sizes and shapes)
    • Lack a capsule and invade nearby blood vessels, lymphatics, and surrounding structures
    • Ability to metastasize (spread far beyond the tissue of origin)
    • Referred to as "cancer"
    • Named for the cell type from which they originate
    • Carcinoma (from epithelial tissue), or sarcoma (from mesenchymal tissue)
    • Adenocarcinomas (from glandular tissue)
    • Lymphomas (from lymphatic tissue)
    • Leukemias (cancers of blood-forming cells)
    • Two categories: solid tumors (confined to a specific tissue/organ) and hematologic tumors (cells normally found in blood/lymph)
    • 90% of adult human cancers are carcinomas
    • Carcinoma in situ: growth with malignant characteristics but has not yet invaded local tissue (so not technically malignant)
    • Difficult to treat, as it may never spread, remain stable for a long time, become malignant, or regress.
    • Can occur in breast, cervix, skin, stomach

    Cancer Cell Characteristics

    • Genetic instability (high frequency of mutations in cancer cells compared to normal cells)
    • Independent of external growth signals (able to make their own signals)
    • Loss of contact inhibition (continue growing when they come into contact with cells)
    • Decrease in cell adhesion (easily shed from a tumor, increasing possibility of metastasis)
    • Loss of anchorage dependence (can survive and grow under conditions normal cells can't- may help metastasis)
    • Production of unusual antigens (cell surface markers, enzymes, hormones that are not produced by the tissue of origin)
    • Able to divide without limit (immortal), telomerase lengthens telomeres

    Cancer Metabolism

    • Cells have an altered metabolism (increasing anaerobic respiration)
    • They divide rapidly, need building blocks, and often live in anoxic environments.
    • They primarily use anaerobic respiration (glycolysis) even in presence of oxygen
    • This yields less ATP, but lactic acid produced can be used to synthesize other molecules needed for rapid growth

    Cancer Detection-Tools

    • Use a fluorescence compound that is taken up by cells in the same way as glucose but can't be metabolized. It accumulates in cancer cells
    • Geraldine Grows Adorable Corn and Artichokes in Mud

    Metastasis

    • A defining characteristic of cancer
    • Spread of cancer cells from the original site to distant organs and tissues
    • Treatment is more challenging in cases of metastasis
    • Local spread aided by enzymes that break down surrounding tissue
    • Distant spread involves invasion of lymph and blood vessels aided by lymphangiogenesis and neoangiogenesis (growth of lymph and blood vessels into the tumor)
    • Tumour cells lodge first in the sentinel node (initial lymph node that drains the area) for lymph spread
    • For blood spread, the organ next in the vascular pathway is often affected, or an organ with similar environment to the original site (e.g., same types of growth factors)
    • Steps in metastasis include invading interstitial spaces, traveling through lymphatic drainage to primary or sentinel, entering the venous system, evading the immune system, secreting proteolytic enzymes, and releasing cytokines and growth factors

    Local Effects of Tumors

    • Compression (tumor growth impedes function-e.g., headache, nausea, loss of consciousness)
    • Obstruction (blockage to airways or gut)
    • Infarction (tumor growth obstructs vessels-causing necrosis-e.g., blood in stool)
    • Hemorrhage (damage to blood vessels)
    • Rupture/perforation of organs
    • Effusions (inappropriate fluid accumulation/excess fluid)

    Systemic Manifestations of Cancer

    • Paraneoplastic syndrome (symptoms triggered by substances released by cancer cells but not caused by direct local effects)

    Staging

    • Grading: how normal the tumor cells appear (lower grade is closer to normal cells, higher grade is more abnormal)
    • Staging: tumor size and spread (e.g., confined to origin, spread to local lymph nodes, spread to distant sites)

    Treatment

    • Chemotherapy: targets specific metabolic pathways, often used in combinations to decrease side effects, and make more cancer cells sensitive to chemicals. Can be used before or after surgery (adjuvant vs neoadjuvant).
    • Radiation Therapy: damages DNA of cancer cells, especially those that are rapidly renewing, but can be used on localized tissues.
    • Surgery: used to remove localized tumors, can be prophylactically.

    Cancer in Children

    • Rare, but a leading cause of death in children aged 1–14
    • Different types than adult cancers
    • Usually diagnosed during periods of rapid growth
    • Causes are often unknown, but some genetic risk factors are implicated
    • Chemotherapy is used, but tolerance and side-effects vary by tumor type

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    Description

    Test your knowledge on the characteristics of cancer cells, their growth patterns, and the mechanisms that allow them to evade the immune system. This quiz covers various types of cancer, their definitions, and the biological processes involved. Perfect for students studying biology or health sciences.

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