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Questions and Answers
Which of the following is a characteristic of cancer cells?
Which of the following is a characteristic of cancer cells?
Leukemia is a type of solid tumor.
Leukemia is a type of solid tumor.
False (B)
What is the term used for a malignant growth with atypical cells in epithelial tissue that has not yet invaded local tissue?
What is the term used for a malignant growth with atypical cells in epithelial tissue that has not yet invaded local tissue?
Carcinoma in situ
The process of a cancer cell spreading from its original site to other parts of the body is called ______.
The process of a cancer cell spreading from its original site to other parts of the body is called ______.
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Match the following terms with their respective descriptions:
Match the following terms with their respective descriptions:
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Which of the following cancers is NOT a carcinoma?
Which of the following cancers is NOT a carcinoma?
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Normal cells have mechanisms to correct mutations that occur in their DNA.
Normal cells have mechanisms to correct mutations that occur in their DNA.
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Describe one way in which cancer cells can become independent of external growth signals.
Describe one way in which cancer cells can become independent of external growth signals.
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Cancer cells are able to evade the immune system by producing unusual antigens.
Cancer cells are able to evade the immune system by producing unusual antigens.
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The enzyme ____ helps cancer cells to maintain their telomere length, allowing them to divide indefinitely.
The enzyme ____ helps cancer cells to maintain their telomere length, allowing them to divide indefinitely.
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Explain why cancer cells often rely heavily on anaerobic respiration.
Explain why cancer cells often rely heavily on anaerobic respiration.
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Match the following terms with their corresponding descriptions:
Match the following terms with their corresponding descriptions:
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Which of these is NOT a precaution taken during surgery for localized tumors?
Which of these is NOT a precaution taken during surgery for localized tumors?
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Surgery is never used prophylactically in cancer treatment.
Surgery is never used prophylactically in cancer treatment.
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What are the two main types of cancer that children are more likely to develop compared to adults?
What are the two main types of cancer that children are more likely to develop compared to adults?
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Childhood cancers are often diagnosed during periods of rapid ______ and maturation.
Childhood cancers are often diagnosed during periods of rapid ______ and maturation.
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Match the following factors to their potential association with childhood cancer:
Match the following factors to their potential association with childhood cancer:
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Which of the following countries has a higher rate of colon cancer among their populations in the United States?
Which of the following countries has a higher rate of colon cancer among their populations in the United States?
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According to the provided information, heredity plays a significant role in the development of all types of cancer, with inherited factors accounting for the majority of cancer cases.
According to the provided information, heredity plays a significant role in the development of all types of cancer, with inherited factors accounting for the majority of cancer cases.
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What is the relationship between meat consumption and colon cancer rates as shown in the graph?
What is the relationship between meat consumption and colon cancer rates as shown in the graph?
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According to the article, only about ______% of all cancers are linked to heritable factors.
According to the article, only about ______% of all cancers are linked to heritable factors.
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Match the following types of cancer with the corresponding possible contributing factors listed:
Match the following types of cancer with the corresponding possible contributing factors listed:
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Which of the following is a defining characteristic of cancer?
Which of the following is a defining characteristic of cancer?
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Metastasis makes cancer treatment more challenging.
Metastasis makes cancer treatment more challenging.
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What is the name of the first lymph node that drains a particular area, where metastatic cancer cells may lodge?
What is the name of the first lymph node that drains a particular area, where metastatic cancer cells may lodge?
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Cancer cells spread through the ______ system.
Cancer cells spread through the ______ system.
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Match the following types of cancer with their primary mode of metastasis:
Match the following types of cancer with their primary mode of metastasis:
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Benign tumors spread through the lymphatic system.
Benign tumors spread through the lymphatic system.
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What is the name of the process by which cancer cells induce the growth of new blood vessels into the tumor?
What is the name of the process by which cancer cells induce the growth of new blood vessels into the tumor?
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Which of the following mechanisms contributes to cancer cell evasion of the innate immune system?
Which of the following mechanisms contributes to cancer cell evasion of the innate immune system?
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Inflammation and cancer share a common mechanism of cell growth stimulation and blood vessel development.
Inflammation and cancer share a common mechanism of cell growth stimulation and blood vessel development.
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Which of the following viruses is strongly associated with cervical cancer?
Which of the following viruses is strongly associated with cervical cancer?
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Chronic infection with _ has been linked to gastric carcinoma.
Chronic infection with _ has been linked to gastric carcinoma.
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What is the primary mechanism by which viruses can contribute to cancer development?
What is the primary mechanism by which viruses can contribute to cancer development?
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Which of the following environmental factors has been linked to increased cancer risk?
Which of the following environmental factors has been linked to increased cancer risk?
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Epigenetics refers to changes in the sequence of DNA itself, not the genes.
Epigenetics refers to changes in the sequence of DNA itself, not the genes.
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Match each cancer type with the region of highest incidence:
Match each cancer type with the region of highest incidence:
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Explain how the development of a virus-related cancer differs from a cancer caused by environmental factors.
Explain how the development of a virus-related cancer differs from a cancer caused by environmental factors.
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Heredity plays a major role in causing all types of cancer.
Heredity plays a major role in causing all types of cancer.
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The _ of the population may be infected with EBV, but only a small percentage develop EBV-related cancer.
The _ of the population may be infected with EBV, but only a small percentage develop EBV-related cancer.
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Flashcards
Lymphomas
Lymphomas
Cancers originating from lymphatic tissue.
Leukemias
Leukemias
Cancers of blood-forming cells.
Solid tumors
Solid tumors
Tumors initially confined to specific tissues or organs.
Hematologic tumors
Hematologic tumors
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Carcinoma in situ
Carcinoma in situ
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Genetic instability
Genetic instability
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Loss of contact inhibition
Loss of contact inhibition
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Decrease in cell adhesion
Decrease in cell adhesion
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Metastasis
Metastasis
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Local Spread
Local Spread
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Distant Spread
Distant Spread
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Sentinel Node
Sentinel Node
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Carcinomas vs. Sarcomas
Carcinomas vs. Sarcomas
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Proteolytic Enzymes
Proteolytic Enzymes
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Immune Evasion
Immune Evasion
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Lymphangiogenesis & Neoangiogenesis
Lymphangiogenesis & Neoangiogenesis
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Anchorage Dependence
Anchorage Dependence
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Unusual Antigens
Unusual Antigens
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Immortal Cells
Immortal Cells
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Telomeres
Telomeres
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Altered Metabolism
Altered Metabolism
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Anaerobic Respiration
Anaerobic Respiration
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Contact Inhibition
Contact Inhibition
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Glucose Uptake in Cancer
Glucose Uptake in Cancer
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Surgery for localized tumors
Surgery for localized tumors
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Colon Cancer Rates
Colon Cancer Rates
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Childhood cancer types
Childhood cancer types
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Meat Consumption
Meat Consumption
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Genetic risk factors
Genetic risk factors
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Inherited Factors in Cancer
Inherited Factors in Cancer
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Chemotherapy in children
Chemotherapy in children
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Proportion of Patients
Proportion of Patients
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Carcinogens in Workplace
Carcinogens in Workplace
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Long-term effects of cancer treatment
Long-term effects of cancer treatment
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Inflammation and cancer coexist
Inflammation and cancer coexist
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Viruses associated with cancer
Viruses associated with cancer
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Chronic Hepatitis and cancer
Chronic Hepatitis and cancer
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EBV and B cell lymphomas
EBV and B cell lymphomas
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Helicobacter pylori and gastric cancer
Helicobacter pylori and gastric cancer
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Environmental/lifestyle factors
Environmental/lifestyle factors
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Carcinogen interactions
Carcinogen interactions
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Epidemiological studies
Epidemiological studies
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Cancers from inheritance
Cancers from inheritance
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Cancer resistance variability
Cancer resistance variability
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Study Notes
Neoplasms
- Neoplasm is a new growth, a tumor
- Two types: benign and malignant (cancer)
Benign Tumors
- Have lost ability to control proliferation, but growth is slow
- Made of well-differentiated cells and organized stroma
- Do not invade beyond their capsule
- Do not metastasize
- Named for the tissue of origin with the suffix "oma"
- Lipoma – benign tumor of fat cells
- Can still cause problems if growth interferes with surrounding tissue function (e.g., compression of brain tissue, or inappropriate hormone production)
Malignant Tumors (Cancer)
- More rapid growth rate
- Loss of differentiation (anaplasia) – cells are pleomorphic (different sizes and shapes)
- Lack a capsule and invade nearby blood vessels, lymphatics, and surrounding structures
- Ability to metastasize (spread far beyond the tissue of origin)
- Referred to as "cancer"
- Named for the cell type from which they originate
- Carcinoma (from epithelial tissue), or sarcoma (from mesenchymal tissue)
- Adenocarcinomas (from glandular tissue)
- Lymphomas (from lymphatic tissue)
- Leukemias (cancers of blood-forming cells)
- Two categories: solid tumors (confined to a specific tissue/organ) and hematologic tumors (cells normally found in blood/lymph)
- 90% of adult human cancers are carcinomas
- Carcinoma in situ: growth with malignant characteristics but has not yet invaded local tissue (so not technically malignant)
- Difficult to treat, as it may never spread, remain stable for a long time, become malignant, or regress.
- Can occur in breast, cervix, skin, stomach
Cancer Cell Characteristics
- Genetic instability (high frequency of mutations in cancer cells compared to normal cells)
- Independent of external growth signals (able to make their own signals)
- Loss of contact inhibition (continue growing when they come into contact with cells)
- Decrease in cell adhesion (easily shed from a tumor, increasing possibility of metastasis)
- Loss of anchorage dependence (can survive and grow under conditions normal cells can't- may help metastasis)
- Production of unusual antigens (cell surface markers, enzymes, hormones that are not produced by the tissue of origin)
- Able to divide without limit (immortal), telomerase lengthens telomeres
Cancer Metabolism
- Cells have an altered metabolism (increasing anaerobic respiration)
- They divide rapidly, need building blocks, and often live in anoxic environments.
- They primarily use anaerobic respiration (glycolysis) even in presence of oxygen
- This yields less ATP, but lactic acid produced can be used to synthesize other molecules needed for rapid growth
Cancer Detection-Tools
- Use a fluorescence compound that is taken up by cells in the same way as glucose but can't be metabolized. It accumulates in cancer cells
- Geraldine Grows Adorable Corn and Artichokes in Mud
Metastasis
- A defining characteristic of cancer
- Spread of cancer cells from the original site to distant organs and tissues
- Treatment is more challenging in cases of metastasis
- Local spread aided by enzymes that break down surrounding tissue
- Distant spread involves invasion of lymph and blood vessels aided by lymphangiogenesis and neoangiogenesis (growth of lymph and blood vessels into the tumor)
- Tumour cells lodge first in the sentinel node (initial lymph node that drains the area) for lymph spread
- For blood spread, the organ next in the vascular pathway is often affected, or an organ with similar environment to the original site (e.g., same types of growth factors)
- Steps in metastasis include invading interstitial spaces, traveling through lymphatic drainage to primary or sentinel, entering the venous system, evading the immune system, secreting proteolytic enzymes, and releasing cytokines and growth factors
Local Effects of Tumors
- Compression (tumor growth impedes function-e.g., headache, nausea, loss of consciousness)
- Obstruction (blockage to airways or gut)
- Infarction (tumor growth obstructs vessels-causing necrosis-e.g., blood in stool)
- Hemorrhage (damage to blood vessels)
- Rupture/perforation of organs
- Effusions (inappropriate fluid accumulation/excess fluid)
Systemic Manifestations of Cancer
- Paraneoplastic syndrome (symptoms triggered by substances released by cancer cells but not caused by direct local effects)
Staging
- Grading: how normal the tumor cells appear (lower grade is closer to normal cells, higher grade is more abnormal)
- Staging: tumor size and spread (e.g., confined to origin, spread to local lymph nodes, spread to distant sites)
Treatment
- Chemotherapy: targets specific metabolic pathways, often used in combinations to decrease side effects, and make more cancer cells sensitive to chemicals. Can be used before or after surgery (adjuvant vs neoadjuvant).
- Radiation Therapy: damages DNA of cancer cells, especially those that are rapidly renewing, but can be used on localized tissues.
- Surgery: used to remove localized tumors, can be prophylactically.
Cancer in Children
- Rare, but a leading cause of death in children aged 1–14
- Different types than adult cancers
- Usually diagnosed during periods of rapid growth
- Causes are often unknown, but some genetic risk factors are implicated
- Chemotherapy is used, but tolerance and side-effects vary by tumor type
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Description
Test your knowledge on the characteristics of cancer cells, their growth patterns, and the mechanisms that allow them to evade the immune system. This quiz covers various types of cancer, their definitions, and the biological processes involved. Perfect for students studying biology or health sciences.