Cancer Biology and Tumor Characteristics
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Questions and Answers

Which of the following features is characteristic of malignant tumors?

  • Cohesive growth with a capsule and basement membrane
  • Well-differentiated cells
  • Infiltrative growth with poorly cohesive cells (correct)
  • Slow rate of growth with few, normal mitotic figures
  • What is the implication of a tumor having a longer doubling time?

  • The tumor is less likely to metastasize.
  • The tumor is growing more rapidly.
  • The tumor is growing more slowly. (correct)
  • The tumor is more likely to metastasize.
  • What differentiates benign dysplasia of the breast from malignant breast cancer?

  • The presence of apocrine metaplasia
  • The presence of hyperplastic changes
  • The presence of cysts and microcalcifications
  • Invasive growth and metastasis (correct)
  • What is the significance of a tumor's fraction of cells in the replicative pool?

    <p>It reflects the tumor's growth rate. (C)</p> Signup and view all the answers

    Which of the following is a definitive sign of malignancy?

    <p>Metastasis (B)</p> Signup and view all the answers

    What are the hallmark characteristics of a koilocyte?

    <p>Large, dark nucleus with a halo and thickened cytoplasm (C)</p> Signup and view all the answers

    Which of these is NOT a characteristic of cancer cell transformation and progression?

    <p>Increased sensitivity to apoptosis (C)</p> Signup and view all the answers

    What is the significance of precancerous changes in the cervix?

    <p>They can be detected early by PAP screening and potentially treated before becoming invasive. (A)</p> Signup and view all the answers

    Which of the following HPV types are considered low risk for cervical cancer?

    <p>HPV types 6 and 11 (B)</p> Signup and view all the answers

    What is the role of telomerase in cancer cell transformation?

    <p>Telomerase helps maintain the length of telomeres, allowing for unlimited replication. (B)</p> Signup and view all the answers

    Which of these statements regarding cervical intraepithelial neoplasia (CIN) is FALSE?

    <p>CIN I indicates severe dysplasia and the highest risk of progression to invasive cancer. (C)</p> Signup and view all the answers

    Which of the following is NOT a predisposing factor for cancer development?

    <p>Exposure to sunlight (for all cancers) (A)</p> Signup and view all the answers

    What is the primary function of the PAP smear screening test?

    <p>To diagnose the presence of precancerous changes in the cervix. (A)</p> Signup and view all the answers

    Which of these accurately describes a proto-oncogene?

    <p>A normal gene that regulates cell growth and division. (A)</p> Signup and view all the answers

    What is the primary function of the p53 tumor suppressor gene?

    <p>Monitoring DNA damage and inducing cell cycle arrest or apoptosis (D)</p> Signup and view all the answers

    How does squamous cell carcinoma of the cervix typically spread?

    <p>All of the above. (D)</p> Signup and view all the answers

    What is the most common symptom of invasive squamous cell carcinoma of the cervix?

    <p>Unusual vaginal bleeding. (D)</p> Signup and view all the answers

    Which statement accurately describes the link between HPV infection and squamous cell carcinoma of the cervix?

    <p>HPV infection is a significant risk factor for developing squamous cell carcinoma of the cervix. (D)</p> Signup and view all the answers

    Which of the following scenarios would be most likely to result in a lethal tumor burden due to rapid growth?

    <p>A tumor with a doubling time of 6 months and a high proportion of replicative cells. (A)</p> Signup and view all the answers

    Considering the information provided, which of the following statements is TRUE about the relationship between tumor growth rate and tumor stem cells?

    <p>Tumor stem cells contribute to tumor growth by maintaining a pool of cells for replication, even if they are not all actively dividing. (D)</p> Signup and view all the answers

    Based on the provided information, which of the following scenarios would be most characteristic of a benign tumor?

    <p>Slow, progressive growth, well-defined capsule, and a high degree of cellular differentiation. (C)</p> Signup and view all the answers

    A pathologist examining a tumor biopsy observes cells with abnormal mitotic figures and a lack of differentiation. How would they classify this tumor's behavior based on the given information?

    <p>Malignant, due to the presence of abnormal mitotic figures and a lack of differentiation. (A)</p> Signup and view all the answers

    Considering the features of benign and malignant tumors, which of the following scenarios would be most suggestive of malignancy?

    <p>A tumor with a history of rapid growth, invasion into surrounding tissues, and the presence of metastases. (A)</p> Signup and view all the answers

    Which of the following statements accurately reflects the relationship between viral exposure and cancer development?

    <p>Viral exposure is a major risk factor for certain cancers but does not directly cause all cancers. (B)</p> Signup and view all the answers

    Which of these statements best explains the significance of a tumor's 'limitless replicative potential' as a hallmark of cancer progression?

    <p>The tumor can indefinitely divide and multiply, leading to uncontrolled growth and the formation of metastases. (B)</p> Signup and view all the answers

    How do 'tumor suppressor genes' contribute to the prevention of cancer development?

    <p>They induce apoptosis in cells with damaged DNA, eliminating potential cancer cells before they can proliferate. (A)</p> Signup and view all the answers

    Based on the content provided, which of the following factors contributes to the higher incidence of melanomas in New Zealand compared to Iceland?

    <p>Higher levels of ultraviolet radiation exposure in New Zealand. (B)</p> Signup and view all the answers

    Which statement accurately describes the role of 'non-lethal genetic damage' in the development of a tumor?

    <p>It creates a predisposition for tumor formation, but requires additional mutations and environmental factors to initiate tumor growth. (D)</p> Signup and view all the answers

    A patient presents with a cervical lesion showing moderate dysplasia. What grade of cervical intraepithelial neoplasia (CIN) would this correspond to?

    <p>CIN II (C)</p> Signup and view all the answers

    What is the key feature that distinguishes a koilocyte from a normal epithelial cell, making it a hallmark of HPV infection?

    <p>Enlarged, irregular, and hyperchromatic nucleus with a perinuclear halo (C)</p> Signup and view all the answers

    In the context of cervical cancer, what is the significance of the "transformation zone"?

    <p>All of the above. (D)</p> Signup and view all the answers

    Which of the following statements is TRUE regarding the progression of cervical intraepithelial neoplasia (CIN) to invasive squamous cell carcinoma?

    <p>Progression is a slow and unpredictable process, potentially taking decades. (C)</p> Signup and view all the answers

    What is the primary mechanism by which squamous cell carcinoma of the cervix spreads?

    <p>All of the above. (D)</p> Signup and view all the answers

    Which of the following HPV types is classified as a high-risk type, predisposing individuals to high-grade intraepithelial neoplasia and a higher risk of cervical cancer?

    <p>HPV type 16 (B), HPV type 18 (C)</p> Signup and view all the answers

    A patient presents with atypical cells on a PAP smear, indicating possible precancerous changes. What is the MOST likely diagnosis for the patient?

    <p>Cervical intraepithelial neoplasia (CIN) (A)</p> Signup and view all the answers

    What is the underlying rationale for the effectiveness of the PAP smear screening test in reducing cervical cancer incidence?

    <p>It detects precancerous changes, such as koilocytes and dysplasia, allowing for early intervention and preventing cancer progression. (D)</p> Signup and view all the answers

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