Podcast
Questions and Answers
What makes up 10% of cancers?
What makes up 10% of cancers?
- Somatic mutations
- Acquired DNA damage
- Germ-line mutations
- Inherited DNA damage (correct)
What type of DNA damage increases with age, leading to an increased risk of cancer?
What type of DNA damage increases with age, leading to an increased risk of cancer?
- Germ-line mutations
- Acquired DNA damage
- Somatic mutations (correct)
- Inherited DNA damage
Which type of DNA mutation/error is carried by every cell in the body in inherited cases?
Which type of DNA mutation/error is carried by every cell in the body in inherited cases?
- Somatic mutations
- Environmental exposures
- Germ-line mutations (correct)
- Acquired DNA damage
What do acquired mutations in a cell may eventually lead to?
What do acquired mutations in a cell may eventually lead to?
Which environmental exposure can induce acquired DNA damage?
Which environmental exposure can induce acquired DNA damage?
What type of DNA mutation/error is only carried by the cancer cells and not the normal cells?
What type of DNA mutation/error is only carried by the cancer cells and not the normal cells?
What is a key consideration before conducting genetic testing for cancer susceptibility?
What is a key consideration before conducting genetic testing for cancer susceptibility?
What is a challenge associated with molecular screening to detect a mutation in an affected individual or family?
What is a challenge associated with molecular screening to detect a mutation in an affected individual or family?
What is the primary cause of cancer, as discussed in the presentation?
What is the primary cause of cancer, as discussed in the presentation?
What is a significant challenge in genetic testing for cancer susceptibility?
What is a significant challenge in genetic testing for cancer susceptibility?
What problem arises due to the accumulation of multiple DNA errors/mutations?
What problem arises due to the accumulation of multiple DNA errors/mutations?
What is the main limitation of conducting genetic testing for cancer susceptibility in unaffected individuals?
What is the main limitation of conducting genetic testing for cancer susceptibility in unaffected individuals?
Why is cancer susceptibility testing not considered appropriate for screening unaffected individuals?
Why is cancer susceptibility testing not considered appropriate for screening unaffected individuals?
What is the primary benefit expected from genetic testing for cancer susceptibility?
What is the primary benefit expected from genetic testing for cancer susceptibility?
What are the implications of a common disease like cancer in relation to phenocopies?
What are the implications of a common disease like cancer in relation to phenocopies?
What makes cancer susceptibility testing more appropriate for specific ethnic groups?
What makes cancer susceptibility testing more appropriate for specific ethnic groups?
Which factor is NOT mentioned as a cause of cancer in the text?
Which factor is NOT mentioned as a cause of cancer in the text?
The presence of which virus is NOT associated with a type of cancer according to the text?
The presence of which virus is NOT associated with a type of cancer according to the text?
Which syndrome is NOT listed as an inherited cancer predisposition syndrome in the text?
Which syndrome is NOT listed as an inherited cancer predisposition syndrome in the text?
What is the main cause of cancer mentioned in the text?
What is the main cause of cancer mentioned in the text?
Which type of cells are particularly susceptible to genetic damage and cancer, according to the text?
Which type of cells are particularly susceptible to genetic damage and cancer, according to the text?
What accounts for up to 80% of the carcinogens that individuals are exposed to in their diet, according to the text?
What accounts for up to 80% of the carcinogens that individuals are exposed to in their diet, according to the text?
What factor can transform a cell by altering critical genes that regulate cell growth, as mentioned in the text?
What factor can transform a cell by altering critical genes that regulate cell growth, as mentioned in the text?
What kind of virus can cause lymphoma, as mentioned in the text?
What kind of virus can cause lymphoma, as mentioned in the text?
What feature suggests an inherited cancer susceptibility syndrome?
What feature suggests an inherited cancer susceptibility syndrome?
What is the lifetime risk of breast cancer for individuals with BRCA1 and BRCA2 mutations?
What is the lifetime risk of breast cancer for individuals with BRCA1 and BRCA2 mutations?
Which of the following features indicate an increased likelihood of an individual having BRCA mutations?
Which of the following features indicate an increased likelihood of an individual having BRCA mutations?
What is the ultimate goal in the management of any patient with a familial cancer syndrome?
What is the ultimate goal in the management of any patient with a familial cancer syndrome?
Which statement is true about the identification of inherited cancer susceptibility genes?
Which statement is true about the identification of inherited cancer susceptibility genes?
What plays a role in familial cancer and may also be implicated in sporadic cancer?
What plays a role in familial cancer and may also be implicated in sporadic cancer?
What percentage of individuals with a specific genetic defect will get colon cancer in some colon cancer syndromes?
What percentage of individuals with a specific genetic defect will get colon cancer in some colon cancer syndromes?
Which statement is true about the cause of cancer?
Which statement is true about the cause of cancer?
What is the main benefit of screening for familial cancer syndromes?
What is the main benefit of screening for familial cancer syndromes?
Which testing strategy is considered optimal for individuals from families affected by breast cancer?
Which testing strategy is considered optimal for individuals from families affected by breast cancer?
What are the common hereditary breast cancer genes?
What are the common hereditary breast cancer genes?
What is the estimated lifetime risk of ovarian cancer for individuals with hereditary breast and ovarian cancer syndromes?
What is the estimated lifetime risk of ovarian cancer for individuals with hereditary breast and ovarian cancer syndromes?
What are some features that indicate an increased likelihood of an individual having BRCA mutations?
What are some features that indicate an increased likelihood of an individual having BRCA mutations?
