10 Questions
What type of genes are oncogenes?
Dominant-acting stimulatory genes
Which of the following statements about proto-oncogenes is true?
They are responsible for basic cellular functions in normal cells.
When do tumor-suppressor genes become inactive?
When they lose heterozygosity
What is the effect of gain-of-function mutations in oncogenes?
They promote abnormal cell growth
Which type of mutation results in the encoded protein being expressed in a cell type where it is not normally expressed?
Gain-of-function mutation
What is the primary function of proto-oncogenes in normal cells?
Promote normal cellular functions
How do oncogenes differ from proto-oncogenes?
Oncogenes have gain-of-function mutations.
What effect do tumor-suppressor genes have on cell division when they are mutated?
They promote abnormal cell growth
What is the primary effect of loss of heterozygosity in tumor-suppressor genes?
Inactivation of the tumor-suppressor gene
Which of the following best describes the role of DNA-repair genes in cancer?
Maintaining genomic stability and preventing mutations
This quiz covers inherited forms of cancer, focusing on the genetics behind about 5% to 10% of all cancers involving inherited mutations. Test your knowledge on how these germ-line mutations play a role in certain types of cancer.
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