Calcineurin Inhibitors Mechanism of Action Quiz
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Questions and Answers

What is the main mechanism of action of calcineurin inhibitors (cyclosporine & tacrolimus)?

  • Inhibition of signal transduction through the calcium–calcineurin pathway (correct)
  • Stimulation of cytokine production
  • Activation of the NFAT pathway
  • Enhancement of T-cell activation

    • Which protein does tacrolimus bind to in order to inhibit the activity of calcineurin?

  • CD86
  • Cyclophilin
  • FK-binding protein (FKBP) (correct)
  • CD80

    • What is the preferred calcineurin inhibitor due to its decreased rate of allograft rejection?

  • Mycophenolate mofetil
  • Tacrolimus (correct)
  • Belatacept
  • Cyclosporine

    • Which adverse effect is commonly associated with cyclosporine?

    <p>Hirsutism</p> Signup and view all the answers

    What is the main mechanism of action of belatacept (costimulation blocker)?

    <p>Inhibition of CD28 on APCs</p> Signup and view all the answers

    What is the main mechanism of action of calcineurin inhibitors (cyclosporine & tacrolimus)?

    <p>Block signal transduction through the calcium–calcineurin pathway</p> Signup and view all the answers

    Which adverse effect is commonly associated with cyclosporine and not tacrolimus?

    <p>Excessive hair growth</p> Signup and view all the answers

    What is the preferred calcineurin inhibitor due to its decreased rate of allograft rejection?

    <p>Tacrolimus</p> Signup and view all the answers

    What is the main mechanism of action of belatacept (costimulation blocker)?

    <p>Binds to CD80 and CD86 on APCs</p> Signup and view all the answers

    Which drug–protein complexes inhibit the activity of calcineurin, thereby preventing T-cell activation?

    <p>Cyclosporine-cyclophilin and tacrolimus-FK-binding protein complexes</p> Signup and view all the answers

    Which adverse effect is commonly associated with cyclosporine and not tacrolimus?

    <p>Hirsutism</p> Signup and view all the answers

    What is the primary mechanism of action of belatacept (costimulation blocker)?

    <p>Binding to CD80 and CD86 on APCs</p> Signup and view all the answers

    Which protein does tacrolimus bind to in order to inhibit the activity of calcineurin?

    <p>FK-binding protein (FKBP)</p> Signup and view all the answers

    What is a common adverse effect of calcineurin inhibitors (cyclosporine & tacrolimus)?

    <p>Nephrotoxicity</p> Signup and view all the answers

    Which drug–protein complex inhibits the activity of calcineurin, thereby preventing T-cell activation?

    <p>Tacrolimus-FK-binding protein (FKBP)</p> Signup and view all the answers

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