15 Questions
What is the main mechanism of action of calcineurin inhibitors (cyclosporine & tacrolimus)?
Inhibition of signal transduction through the calcium–calcineurin pathway
Which protein does tacrolimus bind to in order to inhibit the activity of calcineurin?
FK-binding protein (FKBP)
What is the preferred calcineurin inhibitor due to its decreased rate of allograft rejection?
Tacrolimus
Which adverse effect is commonly associated with cyclosporine?
Hirsutism
What is the main mechanism of action of belatacept (costimulation blocker)?
Inhibition of CD28 on APCs
What is the main mechanism of action of calcineurin inhibitors (cyclosporine & tacrolimus)?
Block signal transduction through the calcium–calcineurin pathway
Which adverse effect is commonly associated with cyclosporine and not tacrolimus?
Excessive hair growth
What is the preferred calcineurin inhibitor due to its decreased rate of allograft rejection?
Tacrolimus
What is the main mechanism of action of belatacept (costimulation blocker)?
Binds to CD80 and CD86 on APCs
Which drug–protein complexes inhibit the activity of calcineurin, thereby preventing T-cell activation?
Cyclosporine-cyclophilin and tacrolimus-FK-binding protein complexes
Which adverse effect is commonly associated with cyclosporine and not tacrolimus?
Hirsutism
What is the primary mechanism of action of belatacept (costimulation blocker)?
Binding to CD80 and CD86 on APCs
Which protein does tacrolimus bind to in order to inhibit the activity of calcineurin?
FK-binding protein (FKBP)
What is a common adverse effect of calcineurin inhibitors (cyclosporine & tacrolimus)?
Nephrotoxicity
Which drug–protein complex inhibits the activity of calcineurin, thereby preventing T-cell activation?
Tacrolimus-FK-binding protein (FKBP)
Test your knowledge about the mechanism of action of calcineurin inhibitors such as cyclosporine and tacrolimus. Learn how these medications block signal transduction through the calcium–calcineurin pathway and impair T-cell activation.
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