12 Questions
Which phase of the cell cycle is primarily affected by Cyclosporin?
G0 and G1 phase
What is the primary mechanism of action of Tacrolimus?
Inhibition of phosphatase activity of calcineurin
Which of the following adverse effects is common to both Cyclosporin and Tacrolimus?
All of the above
Which drug is used topically for severe atopic dermatitis?
Tacrolimus
What is the primary mechanism of action of Sirolimus?
Inhibition of a key regulatory kinase
What is the result of Temisirolimus binding to FKBP-12?
G1 growth arrest
Which of the following adverse drug reactions is associated with polysorbate 80 in the formulation of Temsirolimus?
Hypersensitivity reaction
What is the mechanism of action of Pimecrolimus?
All of the above
Which immunosuppressive drug is converted to its active form, mycophenolic acid, after absorption?
Mycophenolate
Which of the following immunosuppressive drugs is commonly used in combination with Cyclosporine and Corticosteroids for renal, hepatic, and cardiac transplants?
Mycophenolate
What is the effect of high fat on the absorption of Sirolimus oral solution?
Decreases absorption
Which of the following immunosuppressive drugs is metabolized by glucuronidation?
Mycophenolate
Test your knowledge on the mechanisms of action and adverse effects of Cyclosporin and Tacrolimus, two important immunosuppressive drugs. Learn how they work and their potential side effects.
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