Immune System Pharmacology: Cyclosporin and Tacrolimus
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Questions and Answers

Which phase of the cell cycle is primarily affected by Cyclosporin?

  • G0 and G1 phase (correct)
  • M phase
  • G2 phase
  • S phase

    • What is the primary mechanism of action of Tacrolimus?

  • Inhibition of lymphokine production
  • Inhibition of release of IL-2
  • Inhibition of phosphatase activity of calcineurin (correct)
  • Stimulation of T-cell activation

    • Which of the following adverse effects is common to both Cyclosporin and Tacrolimus?

  • Anaphylaxis
  • Nephrotoxicity
  • Hepatotoxicity
  • All of the above (correct)

    • Which drug is used topically for severe atopic dermatitis?

    <p>Tacrolimus</p> Signup and view all the answers

    What is the primary mechanism of action of Sirolimus?

    <p>Inhibition of a key regulatory kinase</p> Signup and view all the answers

    What is the result of Temisirolimus binding to FKBP-12?

    <p>G1 growth arrest</p> Signup and view all the answers

    Which of the following adverse drug reactions is associated with polysorbate 80 in the formulation of Temsirolimus?

    <p>Hypersensitivity reaction</p> Signup and view all the answers

    What is the mechanism of action of Pimecrolimus?

    <p>All of the above</p> Signup and view all the answers

    Which immunosuppressive drug is converted to its active form, mycophenolic acid, after absorption?

    <p>Mycophenolate</p> Signup and view all the answers

    Which of the following immunosuppressive drugs is commonly used in combination with Cyclosporine and Corticosteroids for renal, hepatic, and cardiac transplants?

    <p>Mycophenolate</p> Signup and view all the answers

    What is the effect of high fat on the absorption of Sirolimus oral solution?

    <p>Decreases absorption</p> Signup and view all the answers

    Which of the following immunosuppressive drugs is metabolized by glucuronidation?

    <p>Mycophenolate</p> Signup and view all the answers

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