Blood Transfusion Reaction Resolution

<p>To determine the compatibility of the donor and recipient blood</p> Signup and view all the answers

<p>Antibody screen crossmatch test</p> Signup and view all the answers

<p>To prevent transfusion reactions and increase in vivo survival of red cells</p> Signup and view all the answers

<p>Because they are more reactive at lower temperatures</p> Signup and view all the answers

<p>To detect the presence of any unexpected antibodies in patient serum</p> Signup and view all the answers

<p>Because donated units are already tested for antibodies through antibody paneling</p> Signup and view all the answers

<p>A non-reactive crossmatch</p> Signup and view all the answers

<p>Nearly 50%</p> Signup and view all the answers

<p>ABO/Rh typing</p> Signup and view all the answers

<p>Because it is the most critical pretransfusion serologic test</p> Signup and view all the answers

<p>They decrease to undetectable levels</p> Signup and view all the answers

<p>KIDD BGS</p> Signup and view all the answers

<p>To separate the cells from the serum</p> Signup and view all the answers

<p>IgM Naturally occurring Antibody</p> Signup and view all the answers

<p>To separate particles based on size</p> Signup and view all the answers

<p>IgG Alloantibodies</p> Signup and view all the answers

<p>They are usually IgM in nature</p> Signup and view all the answers

<p>Detecting ABO incompatibility and clinically significant antibodies</p> Signup and view all the answers

<p>To store a backup sample in case the original unit is contaminated</p> Signup and view all the answers

<p>Perform an immediate spin crossmatch</p> Signup and view all the answers

<p>A non-reactive result indicating compatibility</p> Signup and view all the answers

<p>They are a sample of the donor's blood for testing</p> Signup and view all the answers

<p>To prevent contamination of the blood in the bag</p> Signup and view all the answers

<p>Guarantee normal survival of RBCs</p> Signup and view all the answers

<p>When an antibody or previous alloantibody is detected</p> Signup and view all the answers

<p>They cannot guarantee normal survival of RBCs</p> Signup and view all the answers

<p>To verify donor cell ABO compatibility</p> Signup and view all the answers

<p>40%</p> Signup and view all the answers

<p>To remove a portion of blood from a patient for medical reasons</p> Signup and view all the answers

<p>Microplate</p> Signup and view all the answers

<p>To detect antibodies produced after transfusion or pregnancy</p> Signup and view all the answers

<p>They are stored at 1-6 degrees Celsius for at least 7 days</p> Signup and view all the answers

<p>To quarantine prior collections from the donor</p> Signup and view all the answers

<p>To determine the blood type of the donor</p> Signup and view all the answers

<p>To confirm the presence of a pathogen</p> Signup and view all the answers

<p>To detect the presence of syphilis</p> Signup and view all the answers

<p>59 kg</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>False</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>Antibody screen = Detects the presence of any unexpected antibodies in patient serum Crossmatching = Prevents transfusion reactions and increases in vivo survival of red cells Minor Crossmatching = Not required by AABB since 1976 Clinically significant antibodies = Reactive at 37°C</p> Signup and view all the answers

<p>ABO/Rh typing = Prevents ABO errors Antibody identification = Detects the presence of any unexpected antibodies in patient serum Crossmatching = Increases in vivo survival of red cells Antibody paneling = Detects antibodies in donated units</p> Signup and view all the answers

<p>IgM type antibodies = May be detected at lower temperatures Antibody screen = Detects the presence of any unexpected antibodies in patient serum Crossmatching = Prevents transfusion reactions Electronic Crossmatch = Cannot detect all antibodies against donor cells</p> Signup and view all the answers

<p>Universal Recipient = Has antibodies against all ABO blood groups Universal Donor = Has O type blood with no A or B antibodies Autologous Crossmatching = Used for self-donation Pedipacks = Special packs for infant transfusion</p> Signup and view all the answers

<p>Collecting donor samples = To test for antibodies in donated units Quarantine and recipient tracing = To prevent transfusion-transmitted infections Therapeutic phlebotomy = To reduce iron overload Hemagglutination testing = To detect antibodies against donor cells</p> Signup and view all the answers

<p>Packed cells = Refrigerated at 2-6°C for up to 35 days Platelets = Stored at room temperature for up to 5 days Fresh Frozen Plasma = Frozen at -18°C or colder for up to 1 year Cryoprecipitate = Frozen at -18°C or colder for up to 1 year</p> Signup and view all the answers

<p>Immediate Spin (IS) = Room temperature 37°C Incubation = 37°C Antiglobulin (AHG) = Room temperature Thermophase = 60°C</p> Signup and view all the answers

<p>Donor samples = Collected at the same time as the full donor unit Pilot samples = Used for testing and labeling Segments = Attached to the unit of whole blood during specimen collection Cards = Used for tracking and identification</p> Signup and view all the answers

<p>Non-reactive result = Units are compatible for transfusion Reactive result = Units are incompatible for transfusion Incomplete crossmatch = Performed when no antibodies are detected in the antibody screen Complete crossmatch = Performed when antibodies are detected in the antibody screen</p> Signup and view all the answers

<p>ABO/Rh typing = First step Antibody screen = Second step Immediate Spin (IS) = Third step if no antibodies are detected Complete crossmatch = Final step if antibodies are detected</p> Signup and view all the answers

<p>CROSSMATCH WILL = Verify donor cell ABO compatibility and detect most antibodies against donor cells CROSSMATCH WILL NOT = Guarantee normal survival of RBCs or prevent patient from developing an antibody Purpose of attaching segments = To prevent contamination of the blood in the bag Limitation of current crossmatching procedures = Cannot guarantee the fate of a unit of blood to be transfused</p> Signup and view all the answers

<p>Perform ONLY immediate spin phase = If no antibody is detected Perform COMPLETE CROSSMATCH = If antibody or previous alloantibody is detected No need to open the actual bags = To prevent contamination of the blood in the bag Units of Whole Blood with segments attached = For donor cells collection</p> Signup and view all the answers

<p>Importance of crossmatching = To prevent hemolytic reaction from the patient Purpose of collecting donor samples = At the same time as the full donor unit Significance of segments = For donor cells collection Limitation of current crossmatching procedures = Not 100% effective yet</p> Signup and view all the answers

<p>Primary goal of crossmatching = To detect incompatible units Purpose of crossmatching = To prevent hemolytic reaction from the patient Importance of ABO typing = Before proceeding to antibody detection or crossmatching Limitation of current crossmatching procedures = Cannot guarantee the fate of a unit of blood to be transfused</p> Signup and view all the answers

<p>Purpose of crossmatching = To detect incompatible units Importance of attaching segments = To prevent contamination of the blood in the bag Limitation of current crossmatching procedures = Not 100% effective yet Primary goal of crossmatching = To prevent hemolytic reaction from the patient</p> Signup and view all the answers

<p>Manual (IS and IAT) = Uses antigen-antibody reaction and adherence to a solid phase support system Gel Technology = Similar to ReACT; uses an immunoreactive gel and a mixture of protein G and A Electronic (Computerized) Crossmatch = Uses a computerized system to detect antibodies against donor cells Solid-Phase Adherence Assay (SPAA) = Can detect BOTH ANTIGEN and ANTIBODY</p> Signup and view all the answers

<p>Pos Neg = Antibody directed against antigen on screening cell; ID antibody and select antigen negative blood Neg Pos = Antibody directed against antigen on donor cell; ID antibody and select antigen negative blood or perform DAT on donor unit Pos Pos = Antibodies directed against both screening and donor cells; ID antibody and select antigen negative blood for both cells Neg Neg = No antibodies detected; proceed with crossmatch</p> Signup and view all the answers

<p>IgM = Usually detected at lower temperatures IgG = May be attached to donor cells Clinically significant = Reactive at room temperature Naturally occurring = Usually detected in the IS phase</p> Signup and view all the answers

<p>Centrifugation = Primary purpose of centrifugation in the card containing the microtubes Therapeutic phlebotomy = Minimum acceptable hematocrit level for therapeutic phlebotomy Quarantine and recipient tracing = Purpose of quarantine and recipient tracing ABO and D typing = Primary purpose of ABO and D typing</p> Signup and view all the answers

<p>Crossmatching = Can detect ABO/Rh errors but does not guarantee normal survival of RBCs Electronic crossmatch = Cannot detect all antibodies against donor cells Antibody screening = Limited to detecting antibodies directed against antigens on screening cells Solid-Phase Adherence Assay = Cannot detect antibodies without antigens</p> Signup and view all the answers