Blood Groups Major and Minor Systems Quiz

What is the only blood group system not manufactured by RBCs?

Lewis System

Which blood group system's antigens act as receptors for Helicobacter pylori?

Lewis System

What is the substance that is influenced by the Secretor gene in the Lewis System?

Lewis antigen expression in RBCs and secretions

Describe the developmental sequence of the Lewis antigen from Le(a-b-) to Le(a-b+).

Le(a-b-)→Le(a+b-)→Le(a+b+)→Le(a-b+) Signup and view all the answers

In the Lewis System, what phenotypes are included?

Le(a+b-), Le(a-b+), Le(a-b-) Signup and view all the answers

When is the Le b antigen present in an individual?

When the individual has both Lewis and Secretor gene Signup and view all the answers

What is the association of anti-I autoantibody?

Cold agglutinin syndrome, especially in cases of primary atypical pneumonia (Mycoplasma pneumoniae) Signup and view all the answers

Which infection is associated with the presence of anti-i autoantibody?

Infectious mononucleosis (caused by EBV) Signup and view all the answers

How can anti-P1 antibody be neutralized?

Using hydatid cyst fluid from Echinococcus granulosus infection, pigeon droppings, or turtle dove eggwhite Signup and view all the answers

What is the association of Anti-Tja (Anti-PP1Pk) autoantibody?

First described in a patient with adenocarcinoma of the stomach Signup and view all the answers

Which disease is associated with autoanti-P autoantibody?

Paroxysmal cold hemoglobinuria (PCH) Signup and view all the answers

What is the receptor for Parvovirus B19 on the blood group system?

P antigen Signup and view all the answers

What conditions can influence changes in Lewis Phenotype?

Pregnancy, Cancer, Viral and Parasitic infections, Alcoholic cirrhosis Signup and view all the answers

What type of antibodies are Lewis antibodies and why are they not clinically significant?

Naturally occurring IgM, cold reactive, can be neutralized by Lewis substances in secretions like plasma or saliva Signup and view all the answers

Where are MN antigens found, and how do M and N antigens differ?

MN antigens are found in glycophorin A; M and N antigens differ in amino acid residues at positions 1 and 5. Signup and view all the answers

What treatment destroys MN antigens, and what is the nature of Anti-M antibodies?

MN antigens are destroyed by enzyme treatment; Anti-M antibodies are naturally occurring, saline agglutinins, cold reactive, IgM. Signup and view all the answers

Where are Ss antigens found, and what is the nature of Anti-N antibodies?

Ss antigens are found in glycophorin B; Anti-N antibodies are cold reactive, often IgM, may be found in renal patients dialyzed with formaldehyde equipment. Signup and view all the answers

What does the U phenotype represent, and who typically forms anti-U antibodies?

U phenotype represents universal; anti-U is formed by S-s- negative individuals usually of black origins (Black Africans). Signup and view all the answers

What is the genetic basis of the McLeod phenotype in the Kell blood group system?

X-linked inheritance Signup and view all the answers

Which population is associated with the Duffy null (Fy a-b-) phenotype?

African-American population Signup and view all the answers

What enzyme deficiency is seen in patients with the McLeod phenotype?

NADH-oxidase Signup and view all the answers

Why is the Duffy null (Fy a-b-) phenotype associated with resistance against Plasmodium vivax infection?

Confers resistance against Plasmodium vivax infection Signup and view all the answers

What is the main reason why Kidd antibodies cause Delayed Hemolytic Transfusion Reaction (DHTR)?

Rapid disappearance both in vivo and in vitro Signup and view all the answers

Which RBC phenotype resists lysis in 2M urea in the Kidd blood group system?

Jk(a-b-) or Jk null phenotype Signup and view all the answers

What is the name of the blood group system that was named from the misinterpretation of the blood donor's name, Luteran?

LUTHERAN BLOOD GROUP SYSTEM Signup and view all the answers

Where are the Diego blood group system antigens located?

anion exchange protein (AE-1), AKA the erythrocyte band Signup and view all the answers

What results from mutations in the AE-1 protein?

hereditary spherocytosis, congenital acanthocytosis, and southeast Asian ovalocytosis Signup and view all the answers

Which blood group system antigens are expressed by the RBC adhesion protein ERMAP in humans?

SCIANNA BLOOD GROUP SYSTEM Signup and view all the answers

What is the thermal optimum for Anti-Lua antibody?

12-23C Signup and view all the answers

What type of gene leads to Lu(a-b-) phenotype?

amorphic gene (Lu, recessive type) or inhibitor gene (InLu, dominant type) Signup and view all the answers