46 Questions
What is the genotype of an individual who is Leb positive?
Lele/Sese
What is the frequency of the Le(a-b+) phenotype in the Black population?
55%
What is the characteristic of MN antigens that makes them useful in paternity testing?
They are codominant alleles
What is the amino acid residue at position 1 of the N antigen?
Leucine
What is the characteristic of Lewis antibodies that makes them useful in identifying other antibodies in serum?
They can be neutralized using commercially prepared Lewis substance
What is the effect of the interaction between the Le gene and the Se gene on the Lewis phenotype?
The Le gene and the Se gene interact to produce a unique phenotype
What is the function of the Lewis gene (Le) in the Lewis blood group system?
Codes for the production of fucosyltransferase enzyme 1
How do erythrocytes acquire the Lewis phenotype?
By adsorbing Lewis substances from the plasma
What is true about the Lewis antigen?
It is soluble and found in plasma and saliva
What is the function of the Leb antigen?
It is the receptor for Helicobacter pylori
What determines the secretor status?
The Se gene
What is the genotype of an individual who does not produce any Lewis antigen?
lele
What type of molecules are Lewis antigens found in secretions?
Glycoproteins
What is the role of the H gene in the Lewis blood group system?
It produces the ability to secrete H antigen
What is the effect of the lele genotype on Lewis antigen expression?
It does not produce any Lewis antigen
What is the function of the fucosyltransferase enzyme?
It converts the precursor material to Lea substance
What is the type of bacterium associated with gastritis and peptic ulcer disease that the Leb antigen is a receptor for?
Helicobacter pylori
What is the characteristic of Lewis antigens that distinguishes them from other blood group antigens?
They are soluble and found in plasma and saliva
What is the genotype of an individual who has both the Lea and Leb antigens on their red cells?
Lele/Lele
What is the characteristic of the MN antigens that makes them susceptible to destruction?
They are easily destroyed or removed by enzymes
What is the frequency of the Le(a-b-) phenotype in the White population?
6%
What is the characteristic of the Lewis antibodies that makes them activate the complement?
They can cause in vivo and in vitro hemolysis
What is the amino acid residue at position 5 of the M antigen?
Glycine
What is the result of the interaction between the Le gene and the Se gene on the Lewis phenotype?
The Le gene and the Se gene are codominant
On which chromosome are the GE antigens inherited?
Chromosome 2
Which of the following is a high-incidence antigen in the Gerbich Blood Group System?
Ge2
What is the name of the phenotype characterized by the absence of all GE antigens and a change in electrolyte morphology in the form of elliptocytosis?
Leach phenotype
Which antigen is carried by decay accelerating factor (DAF) and is involved in the regulation of complement activation?
Cra
What is the characteristic of anti-Ge2 and anti-Ge3 antibodies?
They are naturally occurring and can cause acute transfusion reactions
Which of the following antigens is a low-incidence antigen in the Gerbich Blood Group System?
Wb
What is the percentage of the general population that has the Yta high-incidence antigen?
99.8%
On which protein is the Xga antigen carried?
A protein with cell adhesion properties
What is the frequency of the Xg' antigen in females?
89%
What is the characteristic of anti-Dia and anti-Dib antibodies?
IgG, red cell-stimulated
What is the location of the gene that codes for the Xg allele?
Short arm of the X chromosome
What is the characteristic of Sc-1, -2, -3 rare null phenotype?
Found in the Marshall Islands and New Guinea
What is the function of the CD147 protein, which carries the OK blood group antigens?
Immune adhesion
Which antigen is carried on the glycerol transporter aquaporin 3 (AQP3)?
GIL
What is the characteristic of Anti-Vel antibodies?
IgG and causes in vitro hemolysis
Which HLA antigen is detectable on RBCs?
HLA-B7
What is the feature of High-Incidence Antigens unrelated to Principal Blood Group Systems?
Occurring in 99.9% of the population
What is the characteristic of Antibodies to High-Frequency Antigens?
Exhibiting high-titer, low-avidity reactivity
What is the name of the antigen found on the hematopoietic isoform of the CD44 marker?
Ina
Which antigen is found on the glycoprotein CD108?
JMH
What is the function of the Rh-associated glycoprotein (RhAG)?
Essential for Rh antigen expression
Which antigen is known to cause severe immediate HTRs and HDFN?
Ata
Learn about the Lewis antigen system, its production, and characteristics. Understand how erythrocytes acquire the Lewis phenotype and the differences between Lewis antigens and other blood groups.
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