Blood Composition and Function
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Questions and Answers

If a patient has a significantly higher than normal erythrocyte count, which characteristic of their blood would most likely be affected?

  • Volume, increasing above the average of 5 liters
  • Color, shifting towards a brighter red hue
  • Viscosity, resulting in a thicker consistency (correct)
  • Temperature, decreasing below one degree Celsius higher than body temperature

Which of the following best describes the role of capillaries in the cardiovascular system?

  • Pumping blood to maintain constant pressure throughout the body
  • Transporting blood back to the heart from various parts of the body
  • Transporting blood away from the heart to the lungs for oxygenation
  • Allowing the exchange of substances between the blood and body tissues (correct)

A patient's blood pH is measured at 7.30. What does this indicate about their blood's acidity?

  • The blood is slightly acidic, below the normal range. (correct)
  • The blood is within the normal alkaline range.
  • The blood is slightly more alkaline than normal.
  • The reading indicates a high level of oxygen in the blood.

Which scenario would most likely result in blood being a darker red color?

<p>Reduced oxygen levels in the blood as it returns to the heart. (A)</p> Signup and view all the answers

What is the primary function of arteries in the cardiovascular system?

<p>To transport blood away from the heart. (A)</p> Signup and view all the answers

Why is maintaining the appropriate pH crucial for plasma protein integrity?

<p>pH affects the solubility and three-dimensional structure of proteins, which is essential for their function. (A)</p> Signup and view all the answers

What explains the difference in hematocrit levels between adult males and females?

<p>Testosterone stimulates the release of erythropoietin by the kidneys, leading to increased erythrocyte production in males. (C)</p> Signup and view all the answers

How would severe dehydration likely affect a person's hematocrit and why?

<p>Hematocrit would increase because the plasma volume decreases while the number of erythrocytes remains constant. (B)</p> Signup and view all the answers

What are the visual characteristics that help differentiate erythrocytes from leukocytes on a blood smear?

<p>Erythrocytes are pink, anucleate, biconcave discs, while leukocytes are larger, varied in form, and have a noticeable nucleus. (B)</p> Signup and view all the answers

If a patient's blood sample was centrifuged (spun down), which component would you expect to find in the bottom layer of the tube, and why?

<p>Erythrocytes, because they are the densest formed elements and pack at the bottom. (A)</p> Signup and view all the answers

What is the primary role of plasma proteins in maintaining blood volume and pressure?

<p>To exert colloid osmotic pressure, preventing fluid loss from blood. (C)</p> Signup and view all the answers

A patient with advanced liver disease exhibits significant tissue swelling (edema). Which of the following is the most likely underlying cause?

<p>Decreased colloid osmotic pressure due to reduced plasma protein production. (A)</p> Signup and view all the answers

Which characteristic of blood plasma facilitates the dissolution of polar and charged substances?

<p>The aqueous, solution-based nature of plasma. (B)</p> Signup and view all the answers

If a scientist added a large quantity of nonpolar molecules to blood plasma, what compensatory mechanism would the body likely employ to maintain homeostasis?

<p>Increase the synthesis of carrier proteins. (A)</p> Signup and view all the answers

Which of the following plasma components is also known to act as transport proteins?

<p>Plasma Proteins (C)</p> Signup and view all the answers

How would significant burns to a large portion of the body affect colloid osmotic pressure and blood pressure?

<p>Decrease colloid osmotic pressure, leading to decreased blood pressure. (C)</p> Signup and view all the answers

Which of the following best describes the relationship between plasma protein concentration and colloid osmotic pressure?

<p>As plasma protein concentration increases, colloid osmotic pressure increases. (C)</p> Signup and view all the answers

A researcher is studying the composition of blood plasma and observes a sample with unusually low levels of albumin. What effect would this have on the movement of fluids within the body?

<p>Increased fluid movement from blood vessels into tissues. (A)</p> Signup and view all the answers

Where does hematopoiesis primarily occur in the human body?

<p>Red bone marrow (C)</p> Signup and view all the answers

Which of the following formed elements is responsible for transporting oxygen and carbon dioxide?

<p>Erythrocytes (B)</p> Signup and view all the answers

What structural feature of erythrocytes allows them to efficiently transport gases?

<p>Biconcave disc shape (D)</p> Signup and view all the answers

Which of the following components is NOT a part of a hemoglobin molecule?

<p>A phosphate group (A)</p> Signup and view all the answers

What is the role of iron in a hemoglobin molecule?

<p>It binds to oxygen for transport to the tissues. (A)</p> Signup and view all the answers

What is the primary function of erythropoietin (EPO)?

<p>Stimulating red blood cell production (D)</p> Signup and view all the answers

Why might endurance athletes use erythropoietin (EPO)?

<p>To increase oxygen delivery to muscles, improving performance (A)</p> Signup and view all the answers

Which process involves the production of leukocytes?

<p>Leukopoiesis (D)</p> Signup and view all the answers

Which process leads to the formation of platelets?

<p>Thrombopoiesis (A)</p> Signup and view all the answers

How does testosterone influence erythrocyte production?

<p>It stimulates EPO production, leading to higher erythrocyte counts. (D)</p> Signup and view all the answers

Why is it critical to determine the blood type before performing a blood transfusion?

<p>To prevent the recipient's antibodies from clumping the transfused erythrocytes, potentially blocking blood vessels. (B)</p> Signup and view all the answers

An individual with type A blood is being tested. The blood sample agglutinates when mixed with anti-A serum, but not with anti-B serum. What does this indicate about the individual's blood type?

<p>The individual has type A blood. (B)</p> Signup and view all the answers

Why does a second exposure to Rh+ blood in an Rh- individual typically result in a transfusion reaction?

<p>The recipient's body recognizes previously formed anti-Rh antibodies, leading to a faster and more aggressive immune response. (D)</p> Signup and view all the answers

A patient requires a blood transfusion but the laboratory only has type B blood available. If the patient has type O blood, what is the likely outcome if they receive the transfusion and why?

<p>Agglutination, because type O blood contains both anti-A and anti-B antibodies that will react with type B blood. (D)</p> Signup and view all the answers

During an agglutination test, a sample of blood is mixed separately with anti-A serum and anti-B serum. No agglutination occurs in either sample. What blood type is indicated by these results?

<p>Type O (B)</p> Signup and view all the answers

A doctor is explaining the importance of Rh compatibility during pregnancy to a patient who is Rh-. Which statement best describes the primary risk associated with Rh incompatibility?

<p>The mother’s Rh antibodies may attack the fetus’s Rh+ red blood cells, leading to hemolytic disease of the newborn. (D)</p> Signup and view all the answers

A patient with type AB+ blood can receive blood from which of the following blood types without a transfusion reaction?

<p>A+, B+, AB+, AB-, O+, O-, A-, B- (B)</p> Signup and view all the answers

A medical technician is preparing for a blood transfusion. The donor is type A- and the intended recipient is type AB+. Which of the following describes the most likely outcome and immunological basis if the transfusion is performed?

<p>The transfusion will likely proceed without a reaction, because the recipient has no antibodies against the A antigen. (A)</p> Signup and view all the answers

Which type of leukocyte is the most abundant in the blood and serves as the first responder to infection sites?

<p>Neutrophils (D)</p> Signup and view all the answers

What is the primary role of basophils in the immune response?

<p>Releasing histamine and heparin (A)</p> Signup and view all the answers

Which leukocytes are primarily responsible for attacking abnormal and infected tissue cells?

<p>NK cells (natural killer cells) (D)</p> Signup and view all the answers

What process describes leukocytes squeezing through blood vessel walls to enter tissues?

<p>Diapedesis (C)</p> Signup and view all the answers

Which of the following best describes the function of chemotaxis in leukocyte activity?

<p>Attracting leukocytes to chemicals at an infection site (C)</p> Signup and view all the answers

Which type of granulocyte is most active during parasitic worm infections?

<p>Eosinophils (A)</p> Signup and view all the answers

How do monocytes contribute to the immune response once they leave the bloodstream?

<p>They transform into macrophages and phagocytize pathogens. (A)</p> Signup and view all the answers

What is the role of B-lymphocytes in the immune response?

<p>Transforming into plasma cells that produce antibodies (D)</p> Signup and view all the answers

A patient presents with chronic allergy symptoms. Which leukocyte is likely contributing to these symptoms through the release of histamine?

<p>Basophils (C)</p> Signup and view all the answers

In a blood sample, a differential white blood cell count shows an elevated number of eosinophils. Which condition is most likely indicated by this result?

<p>Parasitic worm infection (C)</p> Signup and view all the answers

Which of the following is the primary role of vascular spasms in hemostasis?

<p>Causing vasoconstriction to reduce blood loss from the injured vessel. (C)</p> Signup and view all the answers

What role does von Willebrand factor (vWF) play in platelet plug formation?

<p>It facilitates the adhesion of platelets to exposed collagen at the site of vessel injury. (B)</p> Signup and view all the answers

How does the administration of Vitamin K affect blood coagulation?

<p>It acts as a coenzyme required for the synthesis of several clotting factors. (C)</p> Signup and view all the answers

During the coagulation cascade, what is the role of thrombin?

<p>Catalyzing the conversion of fibrinogen into fibrin. (C)</p> Signup and view all the answers

How do endothelial cells lining the blood vessels prevent undesirable clot formation?

<p>By secreting substances like heparin and PGI2 that inhibit platelet adhesion. (B)</p> Signup and view all the answers

Which of the following events occurs during clot retraction?

<p>Stabilization of the clot by squeezing serum from the fibrin strands. (B)</p> Signup and view all the answers

Why is the rapid removal of clotting factors important in limiting clot growth?

<p>To prevent the coagulation process from spreading beyond the immediate area of the injury. (C)</p> Signup and view all the answers

What is the role of Platelet-Derived Growth Factor (PDGF) in the context of hemostasis and tissue repair?

<p>Stimulating the rebuilding of the blood vessel wall. (A)</p> Signup and view all the answers

How does Vascular Endothelial Growth Factor (VEGF) contribute to the repair of a damaged blood vessel?

<p>By stimulating endothelial cell multiplication to restore the endothelial lining. (D)</p> Signup and view all the answers

What is the role of fibrinolysis in hemostasis?

<p>Dissolving the blood clot after tissue repair. (D)</p> Signup and view all the answers

Why is the Rh factor clinically significant, especially during pregnancy?

<p>Rh incompatibility can cause erythroblastosis fetalis in subsequent pregnancies if an Rh- mother carries an Rh+ fetus. (A)</p> Signup and view all the answers

Which of the following is the most likely consequence of a person with type A blood receiving a transfusion of type B blood?

<p>The recipient's anti-B antibodies will cause agglutination of the transfused type B erythrocytes. (B)</p> Signup and view all the answers

An agglutination test is performed on a blood sample. Agglutination occurs with anti-A serum but not with anti-B serum. Which blood type is indicated by these results?

<p>Type A (B)</p> Signup and view all the answers

During a blood transfusion, what occurs when a recipient's antibodies encounter incompatible antigens on the donor's erythrocytes?

<p>The antibodies bind to the antigens, causing agglutination and potentially blocking blood vessels. (A)</p> Signup and view all the answers

If an Rh-negative individual is exposed to Rh-positive blood for the first time, what immunological process must occur before a subsequent exposure can cause a transfusion reaction?

<p>The individual must first produce anti-Rh antibodies through sensitization. (A)</p> Signup and view all the answers

How do blood vessels maintain blood pressure and prevent it from dropping too low?

<p>By adjusting the diameter of arterioles to control resistance (B)</p> Signup and view all the answers

If a patient has a blood volume of 6 liters, which of the following could this indicate?

<p>It's slightly higher than the normal adult range. (C)</p> Signup and view all the answers

How would a significant increase in the number of red blood cells affect blood viscosity, and why?

<p>Increase viscosity, because a higher concentration of cells increases resistance to flow. (B)</p> Signup and view all the answers

How do blood vessels contribute to the regulation of body temperature?

<p>Constricting superficial blood vessels to decrease heat loss in cold conditions. (C)</p> Signup and view all the answers

What would be the effect on blood pH if someone hyperventilates excessively, and why?

<p>Increase it due to decreased carbon dioxide in the blood. (B)</p> Signup and view all the answers

If blood appears bright red, what does this indicate about its oxygen content?

<p>High oxygen saturation, meaning the blood is oxygenated. (C)</p> Signup and view all the answers

How do carrier proteins assist in the composition of blood plasma?

<p>By transporting nonpolar molecules that cannot dissolve easily in plasma (C)</p> Signup and view all the answers

What effect would liver damage have on blood's ability to maintain appropriate viscosity, and why?

<p>Decrease viscosity due to reduced production of plasma proteins. (A)</p> Signup and view all the answers

In what way do plasma proteins influence fluid distribution between blood and tissues?

<p>By exerting colloid osmotic pressure, which helps retain fluid within the blood vessels (B)</p> Signup and view all the answers

If a patient has a condition that severely reduces their plasma protein levels, what physiological change would most likely occur?

<p>Tissue swelling (edema) due to fluid loss from the blood into tissues (D)</p> Signup and view all the answers

During exercise, blood is redirected to skeletal muscles. How does this redistribution affect blood flow to other parts of the body?

<p>Blood flow to less active tissues decreases to accommodate increased demand in muscles. (D)</p> Signup and view all the answers

How does the concentration of plasma proteins affect blood pressure?

<p>Increased plasma protein levels help maintain blood pressure by retaining fluid within blood vessels (A)</p> Signup and view all the answers

Which of the following best describes the role of LDL and HDL in blood plasma?

<p>They transport cholesterol and other lipids throughout the body (A)</p> Signup and view all the answers

How does the presence of electrolytes in blood plasma contribute to maintaining homeostasis?

<p>By regulating osmotic balance and influencing nerve and muscle function (A)</p> Signup and view all the answers

In cases of severe liver disease, why might a patient develop edema (tissue swelling)?

<p>Reduced production of plasma proteins by the liver decreases colloid osmotic pressure (C)</p> Signup and view all the answers

Which characteristic of blood plasma ensures that polar and charged substances dissolve more readily?

<p>Predominantly aqueous composition (D)</p> Signup and view all the answers

Besides water, what other major component contributes significantly to the overall composition of blood plasma?

<p>Plasma proteins like albumin and globulins (B)</p> Signup and view all the answers

If a patient is found to have a deficiency in enzymes within their blood plasma, what bodily function might be directly compromised?

<p>The catalysis of biochemical reactions (C)</p> Signup and view all the answers

Which of the following best describes the significance of the biconcave disc shape of erythrocytes?

<p>It increases the cell's flexibility and surface area, facilitating gas exchange. (D)</p> Signup and view all the answers

In what way does the lack of a nucleus and organelles contribute to the primary function of erythrocytes?

<p>It allows more space for hemoglobin, maximizing oxygen-carrying capacity. (B)</p> Signup and view all the answers

How does the structure of hemoglobin directly facilitate the transport of oxygen?

<p>The iron ion within each heme group reversibly binds to oxygen. (A)</p> Signup and view all the answers

If a patient has a genetic mutation that impairs the production of alpha and beta globin chains, which of the following would most likely occur?

<p>Reduced flexibility of erythrocytes, making them prone to rupture (D)</p> Signup and view all the answers

How does testosterone contribute to higher erythrocyte counts in males compared to females?

<p>Testosterone stimulates the production of erythropoietin (EPO). (C)</p> Signup and view all the answers

How would prolonged exposure to high altitude affect erythropoiesis?

<p>It would increase erythropoiesis due to increased oxygen demand. (B)</p> Signup and view all the answers

Which of the following best explains how endurance athletes might benefit from erythropoietin (EPO)?

<p>EPO increases the number of erythrocytes, enhancing oxygen delivery to muscles. (B)</p> Signup and view all the answers

Which of the following is a key characteristic that distinguishes leukopoiesis from erythropoiesis and thrombopoiesis?

<p>Leukopoiesis involves the production of cells responsible for immune defense, while erythropoiesis and thrombopoiesis involve oxygen transport and blood clotting, respectively. (D)</p> Signup and view all the answers

In a patient experiencing hypoxia, which process will be stimulated to restore homeostasis?

<p>Increased erythropoiesis to enhance oxygen delivery (D)</p> Signup and view all the answers

A patient with kidney disease has impaired erythropoietin (EPO) production. What is a likely consequence of this condition?

<p>Reduced oxygen-carrying capacity of the blood due to decreased erythrocyte production (A)</p> Signup and view all the answers

How would a significant and sustained increase in testosterone levels likely affect a male's hematocrit, and by what mechanism?

<p>Increase hematocrit by increasing erythropoietin secretion. (B)</p> Signup and view all the answers

Why is the biconcave shape of erythrocytes crucial for their function in oxygen transport throughout the blood?

<p>It maximizes the surface area for gas exchange and allows them to squeeze through narrow capillaries. (D)</p> Signup and view all the answers

If a patient's blood smear shows a significantly lower number of erythrocytes than normal, what physiological consequence would you predict?

<p>Impaired oxygen delivery to tissues, potentially leading to fatigue and cellular dysfunction. (B)</p> Signup and view all the answers

How would a blood sample from a patient with a severe infection likely differ in appearance from a healthy individual's sample on a blood smear?

<p>Higher proportion of leukocytes, possibly with altered morphology. (D)</p> Signup and view all the answers

What physiological mechanism explains why maintaining stable blood pH is critical for the proper functioning of plasma proteins?

<p>Stable pH ensures that plasma proteins maintain their appropriate three-dimensional structure and charge, which is essential for their functions. (A)</p> Signup and view all the answers

In a centrifuged sample of blood, what primarily determines the distinct separation of erythrocytes from the plasma layer?

<p>Erythrocytes have a higher density compared to plasma, causing them to pellet at the bottom. (C)</p> Signup and view all the answers

Why might a patient with chronic kidney disease develop anemia, relating to the information learned?

<p>Damaged kidneys are unable to secrete sufficient erythropoietin, reducing red blood cell production. (D)</p> Signup and view all the answers

How would severe burns over a large area of the body rapidly impact hematocrit levels, and what is the primary mechanism responsible?

<p>Increase hematocrit due to fluid loss and concentration of red blood cells. (B)</p> Signup and view all the answers

What is a key difference visible under a microscope that helps distinguish leukocytes from erythrocytes in a stained blood smear?

<p>Leukocytes are generally larger and possess a noticeable nucleus, while erythrocytes are anucleate. (C)</p> Signup and view all the answers

If a patient is experiencing chronic dehydration, how would this condition be expected to impact their hematocrit levels, and what is the underlying physiological mechanism at play?

<p>Hematocrit would increase because the plasma volume decreases, concentrating the red blood cells. (A)</p> Signup and view all the answers

Flashcards

Blood

A continuously regenerated connective tissue that transports gases, nutrients, wastes, and hormones throughout the body.

Arteries

Carry blood away from the heart.

Veins

Carry blood towards the heart.

Capillaries

Allow the exchange of substances between blood and body tissues.

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Blood Viscosity

The thickness of blood; increases with higher erythrocyte concentration.

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Why is blood pH crucial?

Blood must maintain a specific pH range to ensure plasma proteins retain their structure and function.

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What is hematocrit?

Hematocrit is the percentage of the volume of blood that is composed of formed elements (typically referring to red blood cells).

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Typical hematocrit ranges?

Males typically have a hematocrit of 42-56%, while females have a hematocrit of 38-46%.

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What is a blood smear?

A blood smear is a thin layer of blood spread on a microscope slide and stained to allow for examination of blood cells.

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Appearance of blood cells?

Erythrocytes are pink, anucleate, biconcave discs; leukocytes vary in form and have a noticeable nucleus; platelets are small cell fragments.

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Erythrocyte Fate

The process by which erythrocytes are broken down and recycled.

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Blood Types

A system of classifying blood based on the presence or absence of certain antigens on red blood cells.

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ABO Blood Types

A blood classification system based on the presence or absence of A and B antigens.

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Rh Positive (Rh+)

Indicates the presence of Rh agglutinogens on RBCs.

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Rh Negative (Rh-)

The Rh factor surface protein is not present on red blood cells.

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Agglutination

Clumping of red blood cells due to antibody-antigen interaction.

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Incompatible Transfusion Reaction

Occurs when someone receives an incompatible transfusion.

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Agglutination Test

A test to identify blood type by observing agglutination.

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Blood Plasma

The liquid component of blood, a solution containing dissolved substances.

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Plasma Dissolved Substances

Organic and inorganic molecules and ions dissolved in plasma. Includes electrolytes, nutrients, gases and waste products.

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Plasma Proteins Function

They act as transport proteins for some lipids, hormones, and ions.

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LDL and HDL

Lipoproteins that transport cholesterol in the blood.

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Colloid Osmotic Pressure

Plasma proteins exert this pressure, preventing fluid loss from blood.

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Albumin

Most abundant plasma protein that maintains colloid osmotic pressure.

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Effect of Liver Disease

Decreased production of plasma proteins leading to fluid loss from blood and tissue swelling.

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Solubility in Plasma

Polar or charged substances dissolve directly in plasma, while nonpolar substances need carrier proteins.

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Hematopoiesis

Production of formed elements (blood cells). Occurs in red bone marrow.

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Erythropoiesis

Red blood cell production

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Leukopoiesis

Production of leukocytes (white blood cells).

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Thrombopoiesis

Platelet production

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Erythrocytes

Small, flexible formed elements, lacking a nucleus and organelles, packed with hemoglobin. Transport oxygen and carbon dioxide.

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Hemoglobin

Red-pigmented protein that transports oxygen and carbon dioxide.

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Oxygenated Hemoglobin

Hemoglobin with bound oxygen.

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Deoxygenated Hemoglobin

Hemoglobin without bound oxygen.

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Erythropoietin (EPO)

A hormone that stimulates red blood cell production.

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Testosterone

Hormone that stimulates EPO production.

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Leukocytes

White blood cells that defend against pathogens; contain a nucleus and organelles, but no hemoglobin; exhibit motility and flexibility.

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Diapedesis

The process of leukocytes squeezing through blood vessel walls to enter tissues.

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Chemotaxis

The attraction of leukocytes to chemicals at an infection site.

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Neutrophils

Most numerous leukocyte; first to site of infection; phagocytizes pathogens; numbers increase dramatically in bacterial infections.

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Eosinophils

Leukocytes that phagocytize antigen-antibody complexes or allergens; active in parasitic worm infections.

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Basophils

Leukocytes that release histamine (increases blood vessel diameter) and heparin (inhibits blood clotting).

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Lymphocytes

Manage immune response (T-lymphocytes), produce antibodies (B-lymphocytes), or attack abnormal/infected cells (NK cells).

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Monocytes

Become macrophages; phagocytize bacteria, viruses, and debris in tissues.

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NK cells (natural killer cells)

Attack abnormal and infected tissue cells

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B-lymphocytes

Become plasma cells and produce antibodies

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Hemostasis

A series of reactions designed to stop bleeding.

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Vascular Spasms

Immediate vasoconstriction in response to blood vessel injury.

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Platelet Plug Formation

The formation of a temporary plug to seal a damaged blood vessel.

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Coagulation

The process by which blood transforms from a liquid to a gel, forming a clot.

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Coagulation Requirements

Calcium, clotting factors, platelets, and vitamin K.

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Clotting factors

Inactive enzymes mostly produced by the liver and named by order of discovery.

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Vitamin K

A fat-soluble coenzyme required for the synthesis of several clotting factors in the liver.

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Vascular Spasm Function

Blood vessel constriction to limit blood leakage at the site of injury.

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Platelet Activation

Platelets adhere to exposed collagen, are stimulated by thromboxane A2, and release chemicals to attract more platelets.

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PGI2 Function

Ensures the platelet plug is restricted to the immediate area of injury.

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Cardiovascular System

The system through which blood moves.

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Heart

Pumps blood throughout the body.

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Plasma Solute Concentration

Determines direction of osmosis in blood.

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Blood pH

Blood is slightly alkaline.

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Normal Hematocrit ranges

Adult males: 42-56%; Adult females: 38-46%.

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Erythrocyte appearance

Pink, anucleate, biconcave discs.

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Leukocyte appearance

Larger than erythrocytes, varied in form, with a noticeable nucleus.

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Platelet appearance

Small, cell fragments.

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Blood transport function

Carries oxygen, nutrients, hormones, and waste products.

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Blood temp regulation

By absorbing and distributing heat.

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Effect of altered pH?

It is impaired, potentially denaturing proteins.

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Blood sample separation

Plasma, buffy coat (leukocytes and platelets), and erythrocytes.

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Plasma Protein Levels & Colloid

Plasma proteins level is directly related to colloid osmotic pressure. Higher the concentration in plasma, the higher the pressure.

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Additional Plasma Protein Role

Functions include transport, enzymatic activity and hormonal regulation.

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Testosterone effect on EPO

Hormone that stimulates EPO production, leading to higher erythrocyte counts in males.

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Study Notes

Blood Overview

  • Blood transports gases, nutrients, wastes, and hormones.
  • Blood is transported through the cardiovascular system.
  • The heart pumps blood.
  • Arteries transport blood away from the heart.
  • Veins transport blood toward the heart.
  • Capillaries allow for exchange between blood and body tissues.
  • Blood is a continuously regenerated connective tissue.

Blood Functions

  • Blood transports;
    • Oxygen
    • Nutrients from the gastrointestinal tract
    • Hormones from endocrine glands
    • Metabolic waste.
  • Blood regulates pH and adjusts and maintains body temperature.
  • Blood maintains water contents of cells.
  • WBCs protect against disease by phagocytosis.
  • Blood serves as a reservoir for substances like water and electrolytes
  • Blood performs haemostasis.

Physical Characteristics of Blood

  • High O2 blood is bright red, while low O2 blood is dark red.
  • Normal adult blood volume is about 5,000 cc, or 5 liters.
  • Blood is thick due to its high erythrocyte content, leading to high viscosity.
  • Solute concentration determines the direction of osmosis.
  • Blood temperature is one degree Celsius higher than body temperature.
  • Blood pH ranges from 7.35 to 7.45, which is slightly alkaline, and is crucial for plasma protein integrity.

Whole Blood Composition

  • Plasma accounts for 55% of whole blood.
    • 92% of plasma is water..
    • Proteins account for 7% of plasma
      • Albumins account for 58% of the plasma proteins
      • Globulins account for 37% of plasma proteins
      • Fibrinogen accounts for 4% of plasma proteins
    • Other solutes make up 1% of the plasma
      • Electrolytes
      • Nutrients
      • Respiratory gases
      • Waste products.
  • The buffy coat accounts for less than 1% of whole blood.
    • This contains the platelets and leukocytes
      • Platelet count is 150,000 to 400,000/cubic mm
      • Leukocyte count is 4,500 to 11,000/cubic mm and consists of:
        • Neutrophils comprising 50-70%
        • Lymphocytes comprising 20-40% -Monocytes comprising 2-8% - Eosinophils comprising 1-4% - Basophils comprising 0.5-1%
  • Erythrocytes account for 44% of whole blood.
    • Erythrocyte count is 4.2-6.2 million per cubic mm.

Hematocrit

  • Hematocrit refers to the percentage of volume of all formed and is divided into:
    • Normal Blood Females: 37%-47% Males: 42%-52%
    • Anemia: Depressed hematocrit %
    • Polycythemia: Elevated hematocrit %
  • The clinical definition often refers to the percentage of only erythrocytes,
  • Adult male hematocrit typically ranges from 42-56%, while for adult females it is 38-46%.
  • Males have a higher amount due to the influence of testosterone.
  • With a blood smear, erythrocytes are the most numerous and appear pink, anucleate, and biconcave.
  • Leukocytes are larger than erythrocytes, varied in form, and have a noticeable nucleus.
  • Platelets appear as small fragments of cells.

Composition of Blood - Plasma

  • Whole blood is made up of 55% plasma 45% formed elements. Plasma consists of :
    • 92% Water
    • 7% Proteins; 57-60% Albumins, 38% Globulins, 4 Fibrinogen, 1% Prothrombin
    • 1% Other Solutes; Ions, Nutrients, Waste Products, Gases, Regulatory Substances
  • Formed elements consist of Platelets, Leukocytes and Erythrocytes.

Plasma Proteins

  • Major Types:
    • Albumin: (60%) Major component of osmotic pressure of a plasma + Acts as a transport protein for some lipids, hormones and ions
    • Globulins: (35%) Consists of Antibodies and transport proteins
    • Fibrinogen: (4%) Functions in blood clotting
    • Other: (<1%) Consists of enzymes and hormones
  • It also contains dissolved inorganic and organic molecules, including: - electrolytes - nutrients - gases - waste products
  • Polar or charged substances dissolve easily, while nonpolar molecules require a carrier protein.
  • Plasma proteins exert colloid osmotic pressure, with albumin being the most abundant.
  • This prevents fluid loss from blood as it moves through capillaries and helps maintain blood volume and blood pressure.
  • Can be decreased with diseases, resulting in fluid loss from blood and tissue swelling, particularly in liver diseases.

Hematopoiesis

  • This is the production of the formed elements within the blood- including blood cells
  • This occurs in the red bone marrow
  • Erythropoiesis is the production of red blood cells
  • Leukopoiesis is the production of leukocytes
  • Thrombopoiesis is platelet production

Erythrocytes

  • Small flexible formed element
  • Lack nucleus and cellular organelles: packed with hemoglobin
  • Have biconcave disc structure Have biconcave disc structure, and transport oxygen and carbon dioxide throughout the body.

Hemoglobin

  • Hemoglobin is a red-pigmented protein that transports oxygen and carbon dioxide.
  • It is termed oxygenated or deoxygenated depending on its oxygen content.
  • Each hemoglobin molecule is composed of four globins, two alpha chains and two beta chains.
  • Each chain has a heme group, where a porphyrin ring contains an iron ion
  • Oxygen binds to the iron ion, so each hemoglobin can bind four oxygen molecules.

Erythropoiesis

  • Response to Low O2 levels and stimulates kidneys to produce Erythropoietin.
  • Erythropoietin + raw materials > bloodstream promote Erythropoiesis in Red Bone Marrow
  • New erythrocytes enter bloodstream; function about 120 days
  • Aged and damaged red blood cells are engulfed by macrophages of liver, spleen + bone marrow > hemoglobin is broken down
  • Iron is then stored as ferritin, hemosiderin or bound to transferrin

Blood Types

  • Determined by the presence of antigens on the surface of red blood cells.
  • Rh positive and negative is attributed to the Rhesus monkey.
    • Rh+ If the Rh factor surface protein is present on red blood cells
    • Rh- factor surface protein is absent on presence of blood cells
  • If Rh- individual receives anti-Rh antibodies, anti-Rh antibodies form.
  • A second exposure the Rh+ to blood will result in a typical transfusion

Erythrocytes/Transfusions

  • Issues arise when someone receives an incompatible blood transfusion.
  • Recipient's antibodies then bind to the transfused blood, causing them to clump together in a process called agglutination.
  • As a result the blood vessels gets blocked and prevents normal blood flow,

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Test your knowledge of blood components, pH levels, and their functions within the cardiovascular system. Questions cover erythrocyte count, blood acidity, hematocrit levels, and the roles of arteries and capillaries. Explore the impact of dehydration and the visual characteristics differentiating blood cells.

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