Blood Components: Reentry into Vasculature
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Questions and Answers

Where do defective red blood cells undergo selective removal by macrophages?

  • Bone marrow
  • Red pulp (correct)
  • Splenic cords
  • Sinusoids of the liver
  • Which of the following is a major function of the red pulp in the spleen?

  • Hemoglobin synthesis
  • Erythropoiesis
  • Iron storage and recycling (correct)
  • Platelet formation
  • What happens to iron released from hemoglobin during RBC degradation?

  • Stored by platelets
  • Excreted in urine
  • Stored by macrophages in the red pulp (correct)
  • Returned to the bone marrow
  • After splenectomy, where do most abnormal erythrocytes get removed by macrophages?

    <p>Liver sinusoids</p> Signup and view all the answers

    What is the fate of iron-free heme in the spleen?

    <p>Bound to hemopexin or excreted in bile</p> Signup and view all the answers

    Which structure lacks significant smooth muscle and forms the splenic vein?

    <p>Trabecular veins</p> Signup and view all the answers

    What is the main function of the endothelial stave cells that line the sinusoids in the red pulp of the spleen?

    <p>Filtering out effete erythrocytes</p> Signup and view all the answers

    Which component of the splenic sinusoids is highly discontinuous and allows for the passage of blood cells?

    <p>Basement membrane</p> Signup and view all the answers

    In the spleen's open circulation mode, what happens to blood cells that cannot move between the stave cells in the splenic cords?

    <p>They are engulfed by macrophages</p> Signup and view all the answers

    Which structure in the spleen resembles a loosely organized wooden barrel, as depicted in a diagram?

    <p>Endothelial stave cells</p> Signup and view all the answers

    What is the main role of T lymphoblasts in the thymus, according to the text?

    <p>Attaching to cytoreticulum composed of thymic epithelial cells</p> Signup and view all the answers

    What is the key role of thymic epithelial cells (TECs) in the thymus, as mentioned in the text?

    <p>Surrounding blood vessels in the blood-thymus barrier</p> Signup and view all the answers

    What is the role of splenic cords in the red pulp?

    <p>Contain a network of reticular cells and fibers filled with T and B lymphocytes</p> Signup and view all the answers

    What characterizes the endothelial cells in the splenic sinusoids?

    <p>Elongated and sparsely wrapped in reticular fibers</p> Signup and view all the answers

    What is the function of the splenic sinusoids in the red pulp?

    <p>Provide additional immune surveillance of blood</p> Signup and view all the answers

    In the closed circulation through the splenic red pulp, what happens to the blood flow?

    <p>Blood is always enclosed by endothelium</p> Signup and view all the answers

    How are the splenic cords and splenic sinusoids arranged in the red pulp?

    <p>Cords contain reticular cells and fibers filled with lymphocytes, separated by sinusoids</p> Signup and view all the answers

    What distinguishes the open circulation in the splenic red pulp?

    <p>Capillaries empty blood into stroma of splenic cords</p> Signup and view all the answers

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