Blood-Brain Barrier and Drug Delivery: Review Article

BBB selectively controls inward and outward transportation mechanisms, thus advanced smart multifunctional nanomedicines are needed for the effective brain drug delivery and targeting

Intelligent molecular therapies should be designed using such transport machineries for the efficient delivery of designated drugs into the brain

The exceptional functional presence of BBB selectively controls inward and outward transportation mechanisms, thus advanced smart multifunctional nanomedicines are needed for the effective brain drug delivery and targeting

The permeability of BBB appears to be regulated by a range of intricate transport machineries located at the membrane of the BCECs which are deemed to be responsive to autocrine and paracrine stimulations to present their selective barrier functionalities

Intelligent molecular therapies should be designed using such transport machineries for the ______. For better clinical outcomes, these smart pharmaceuticals should be engineered as seamless nanosystems to provide simultaneous imaging and therapy (multimodal theranostics)

Brain capillary endothelial cells (BCECs) form unique biological structure and architecture in association with astrocytes and pericytes, in which microenvironment the BCECs express restrictive tight junctional complexes that block the paracellular inward/outward traverse of biomolecules/compounds. These cells selectively/specifically control the transportation process through carrier and/or receptor mediated transport machineries that can also be exploited for the delivery of pharmaceuticals into the brain.