Impacts of Blood-Brain Barrier in Drug Delivery and Targeting of Brain Tumors

Blood-Brain Barrier primarily protects the brain from undesired blood circulating agents

The permeability of BBB is regulated by transport machineries located at the membrane of the BCECs

Astrocytic end feet and pericytes are the main contributors to the impermeability of BBB

BBB impermeability is mainly due to the tight junctional characteristics of BCECs

Understanding the biofunctions of BBB is not essential for the engineering of intelligent seamless therapeutics

Blood-Brain Barrier (BBB) restricts the entry of blood circulating agents into the brain

Brain capillary endothelial cells (BCECs) form unique biological structure and architecture in association with astrocytes and pericytes

The BCECs express pericellular junctional complexes that facilitate the paracellular inward/outward traverse of biomolecules/compounds

The transportation process through the BBB is solely controlled by carrier mediated transport machineries

The restrictive tight junctional complexes of BCECs can be exploited for the delivery of pharmaceuticals into the brain