Impacts of Blood-Brain Barrier in Drug Delivery

What is the main challenge in delivering drugs to the brain?

Which cells form a unique microenvironment at the blood-brain barrier (BBB)?

What do brain capillary endothelial cells (BCECs) express to block the paracellular traverse of biomolecules/compounds?

How are blood circulating agents selectively controlled at the blood-brain barrier (BBB)?

Which cells can be exploited for the delivery of pharmaceuticals into the brain?

What is the main purpose of intelligent molecular therapies as mentioned in the text?

What is deemed to be responsive to autocrine and paracrine stimulations to present their selective barrier functionalities?

What is the main reason for the impermeability of the blood-brain barrier (BBB) to many compounds, as mentioned in the text?

What did the study supported by electron microscopic cytochemical using 40 kDa horseradish peroxidase (HRP) visualize?

What role do pericyte and astrocyte cells play in relation to the brain capillary endothelial cells (BCECs), as mentioned in the text?

Intelligent molecular therapies should be designed using such transport machineries for the efficient delivery of designated drugs into the ______

The exceptional functional presence of BBB selectively controls inward and outward transportation mechanisms, thus advanced smart multifunctional ______ are needed for the effective brain drug delivery and targeting

Fully understanding the biofunctions of BBB appears to be a central step for engineering of intelligent seamless therapeutics consisting of homing device for targeting, imaging moiety for detecting, and stimuli responsive device for on-demand liberation of therapeutic ______

Since Broman suggested the cerebral capillary endothelial cells' contribution in the physical barrier function of the blood-brain barrier (BBB), it is now clear that BBB protects brain “the holly central ______” from undesired blood circulating agents