Impacts of Blood-Brain Barrier in Drug Delivery
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Questions and Answers

What is the main challenge in delivering drugs to the brain?

  • The selective control of blood circulating agents by specific transport machineries
  • The restrictive tight junctional complexes in brain capillary endothelial cells (correct)
  • The unique biological structure and architecture of brain capillary endothelial cells
  • The association of astrocytes and pericytes with brain capillary endothelial cells

    • Which cells form a unique microenvironment at the blood-brain barrier (BBB)?

  • Neurons
  • Pericytes only
  • Astrocytes only
  • Brain capillary endothelial cells (BCECs) (correct)

    • What do brain capillary endothelial cells (BCECs) express to block the paracellular traverse of biomolecules/compounds?

  • Exocytosis
  • Carrier mediated transport machineries
  • Restrictive tight junctional complexes (correct)
  • Receptor mediated transport machineries

    • How are blood circulating agents selectively controlled at the blood-brain barrier (BBB)?

    <p>By specific transport machineries</p> Signup and view all the answers

    Which cells can be exploited for the delivery of pharmaceuticals into the brain?

    <p>Brain capillary endothelial cells (BCECs)</p> Signup and view all the answers

    What is the main purpose of intelligent molecular therapies as mentioned in the text?

    <p>To provide simultaneous imaging and therapy</p> Signup and view all the answers

    What is deemed to be responsive to autocrine and paracrine stimulations to present their selective barrier functionalities?

    <p>The brain capillary endothelial cells (BCECs)</p> Signup and view all the answers

    What is the main reason for the impermeability of the blood-brain barrier (BBB) to many compounds, as mentioned in the text?

    <p>The cellular architecture of brain capillary endothelial cells (BCECs)</p> Signup and view all the answers

    What did the study supported by electron microscopic cytochemical using 40 kDa horseradish peroxidase (HRP) visualize?

    <p>The blood-brain barrier (BBB) after systemic injections</p> Signup and view all the answers

    What role do pericyte and astrocyte cells play in relation to the brain capillary endothelial cells (BCECs), as mentioned in the text?

    <p>They support BCECs physically and by sharing the capillary basement membrane with the endothelium</p> Signup and view all the answers

    Intelligent molecular therapies should be designed using such transport machineries for the efficient delivery of designated drugs into the ______

    <p>brain</p> Signup and view all the answers

    The exceptional functional presence of BBB selectively controls inward and outward transportation mechanisms, thus advanced smart multifunctional ______ are needed for the effective brain drug delivery and targeting

    <p>nanomedicines</p> Signup and view all the answers

    Fully understanding the biofunctions of BBB appears to be a central step for engineering of intelligent seamless therapeutics consisting of homing device for targeting, imaging moiety for detecting, and stimuli responsive device for on-demand liberation of therapeutic ______

    <p>agent</p> Signup and view all the answers

    Since Broman suggested the cerebral capillary endothelial cells' contribution in the physical barrier function of the blood-brain barrier (BBB), it is now clear that BBB protects brain “the holly central ______” from undesired blood circulating agents

    <p>dogma</p> Signup and view all the answers

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