Podcast
Questions and Answers
What is the main challenge in delivering drugs to the brain?
What is the main challenge in delivering drugs to the brain?
- The selective control of blood circulating agents by specific transport machineries
- The restrictive tight junctional complexes in brain capillary endothelial cells (correct)
- The unique biological structure and architecture of brain capillary endothelial cells
- The association of astrocytes and pericytes with brain capillary endothelial cells
Which cells form a unique microenvironment at the blood-brain barrier (BBB)?
Which cells form a unique microenvironment at the blood-brain barrier (BBB)?
- Neurons
- Pericytes only
- Astrocytes only
- Brain capillary endothelial cells (BCECs) (correct)
What do brain capillary endothelial cells (BCECs) express to block the paracellular traverse of biomolecules/compounds?
What do brain capillary endothelial cells (BCECs) express to block the paracellular traverse of biomolecules/compounds?
- Exocytosis
- Carrier mediated transport machineries
- Restrictive tight junctional complexes (correct)
- Receptor mediated transport machineries
How are blood circulating agents selectively controlled at the blood-brain barrier (BBB)?
How are blood circulating agents selectively controlled at the blood-brain barrier (BBB)?
Which cells can be exploited for the delivery of pharmaceuticals into the brain?
Which cells can be exploited for the delivery of pharmaceuticals into the brain?
What is the main purpose of intelligent molecular therapies as mentioned in the text?
What is the main purpose of intelligent molecular therapies as mentioned in the text?
What is deemed to be responsive to autocrine and paracrine stimulations to present their selective barrier functionalities?
What is deemed to be responsive to autocrine and paracrine stimulations to present their selective barrier functionalities?
What is the main reason for the impermeability of the blood-brain barrier (BBB) to many compounds, as mentioned in the text?
What is the main reason for the impermeability of the blood-brain barrier (BBB) to many compounds, as mentioned in the text?
What did the study supported by electron microscopic cytochemical using 40 kDa horseradish peroxidase (HRP) visualize?
What did the study supported by electron microscopic cytochemical using 40 kDa horseradish peroxidase (HRP) visualize?
What role do pericyte and astrocyte cells play in relation to the brain capillary endothelial cells (BCECs), as mentioned in the text?
What role do pericyte and astrocyte cells play in relation to the brain capillary endothelial cells (BCECs), as mentioned in the text?
Intelligent molecular therapies should be designed using such transport machineries for the efficient delivery of designated drugs into the ______
Intelligent molecular therapies should be designed using such transport machineries for the efficient delivery of designated drugs into the ______
The exceptional functional presence of BBB selectively controls inward and outward transportation mechanisms, thus advanced smart multifunctional ______ are needed for the effective brain drug delivery and targeting
The exceptional functional presence of BBB selectively controls inward and outward transportation mechanisms, thus advanced smart multifunctional ______ are needed for the effective brain drug delivery and targeting
Fully understanding the biofunctions of BBB appears to be a central step for engineering of intelligent seamless therapeutics consisting of homing device for targeting, imaging moiety for detecting, and stimuli responsive device for on-demand liberation of therapeutic ______
Fully understanding the biofunctions of BBB appears to be a central step for engineering of intelligent seamless therapeutics consisting of homing device for targeting, imaging moiety for detecting, and stimuli responsive device for on-demand liberation of therapeutic ______
Since Broman suggested the cerebral capillary endothelial cells' contribution in the physical barrier function of the blood-brain barrier (BBB), it is now clear that BBB protects brain “the holly central ______” from undesired blood circulating agents
Since Broman suggested the cerebral capillary endothelial cells' contribution in the physical barrier function of the blood-brain barrier (BBB), it is now clear that BBB protects brain “the holly central ______” from undesired blood circulating agents
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