Podcast
Questions and Answers
What is the main challenge in delivering drugs to the brain?
What is the main challenge in delivering drugs to the brain?
- The lack of effective drug options
- The high permeability of brain capillary endothelial cells
- The abundance of carrier and receptor mediated transport machineries
- The presence of tight junctional complexes (correct)
What do brain capillary endothelial cells (BCECs) express that blocks the paracellular traverse of biomolecules/compounds?
What do brain capillary endothelial cells (BCECs) express that blocks the paracellular traverse of biomolecules/compounds?
- Selective tight junctional complexes (correct)
- High levels of carrier proteins
- Low permeability to water and ions
- Receptor mediated transport machineries
What plays a role in selectively controlling the transportation process at the blood-brain barrier (BBB)?
What plays a role in selectively controlling the transportation process at the blood-brain barrier (BBB)?
- Non-specific transport machineries
- Low expression of tight junctional complexes
- Carrier and receptor mediated transport machineries (correct)
- Permeability to all biomolecules
What is the role of astrocytes and pericytes in the BBB microenvironment?
What is the role of astrocytes and pericytes in the BBB microenvironment?
How can the restrictive properties of BBB be exploited for drug delivery into the brain?
How can the restrictive properties of BBB be exploited for drug delivery into the brain?
What is the main purpose of designing intelligent molecular therapies mentioned in the passage?
What is the main purpose of designing intelligent molecular therapies mentioned in the passage?
What is the main role of the blood-brain barrier (BBB) as highlighted in the passage?
What is the main role of the blood-brain barrier (BBB) as highlighted in the passage?
Why are brain capillary endothelial cells (BCECs) particularly important in relation to the blood-brain barrier?
Why are brain capillary endothelial cells (BCECs) particularly important in relation to the blood-brain barrier?
What is responsible for making BBB impermeable to many compounds?
What is responsible for making BBB impermeable to many compounds?
What is a central step for engineering intelligent seamless therapeutics according to the passage?
What is a central step for engineering intelligent seamless therapeutics according to the passage?
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