10 Questions
What is the main challenge in delivering drugs to the brain?
The presence of tight junctional complexes
What do brain capillary endothelial cells (BCECs) express that blocks the paracellular traverse of biomolecules/compounds?
Selective tight junctional complexes
What plays a role in selectively controlling the transportation process at the blood-brain barrier (BBB)?
Carrier and receptor mediated transport machineries
What is the role of astrocytes and pericytes in the BBB microenvironment?
They form unique biological structure in association with BCECs
How can the restrictive properties of BBB be exploited for drug delivery into the brain?
By utilizing carrier and receptor mediated transport machineries
What is the main purpose of designing intelligent molecular therapies mentioned in the passage?
To provide simultaneous imaging and therapy for better clinical outcomes
What is the main role of the blood-brain barrier (BBB) as highlighted in the passage?
Protecting the brain from undesired blood circulating agents
Why are brain capillary endothelial cells (BCECs) particularly important in relation to the blood-brain barrier?
Due to their collaboration with pericytes and astrocytic end feet
What is responsible for making BBB impermeable to many compounds?
The tight junctional characteristics of BCECs
What is a central step for engineering intelligent seamless therapeutics according to the passage?
Understanding the biofunctions of BBB for targeted drug delivery
Explore the impacts of the blood-brain barrier on drug delivery and targeting of brain tumors in this review article. Gain insights into the challenges and advancements in this field from the perspectives of pharmaceutical nanotechnology and medical sciences.
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