Blood-Brain Barrier and Drug Delivery Review
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Questions and Answers

What is the main challenge in delivering drugs to the brain?

  • The lack of effective drug options
  • The high permeability of brain capillary endothelial cells
  • The abundance of carrier and receptor mediated transport machineries
  • The presence of tight junctional complexes (correct)

    • What do brain capillary endothelial cells (BCECs) express that blocks the paracellular traverse of biomolecules/compounds?

  • Selective tight junctional complexes (correct)
  • High levels of carrier proteins
  • Low permeability to water and ions
  • Receptor mediated transport machineries

    • What plays a role in selectively controlling the transportation process at the blood-brain barrier (BBB)?

  • Non-specific transport machineries
  • Low expression of tight junctional complexes
  • Carrier and receptor mediated transport machineries (correct)
  • Permeability to all biomolecules

    • What is the role of astrocytes and pericytes in the BBB microenvironment?

    <p>They form unique biological structure in association with BCECs</p> Signup and view all the answers

    How can the restrictive properties of BBB be exploited for drug delivery into the brain?

    <p>By utilizing carrier and receptor mediated transport machineries</p> Signup and view all the answers

    What is the main purpose of designing intelligent molecular therapies mentioned in the passage?

    <p>To provide simultaneous imaging and therapy for better clinical outcomes</p> Signup and view all the answers

    What is the main role of the blood-brain barrier (BBB) as highlighted in the passage?

    <p>Protecting the brain from undesired blood circulating agents</p> Signup and view all the answers

    Why are brain capillary endothelial cells (BCECs) particularly important in relation to the blood-brain barrier?

    <p>Due to their collaboration with pericytes and astrocytic end feet</p> Signup and view all the answers

    What is responsible for making BBB impermeable to many compounds?

    <p>The tight junctional characteristics of BCECs</p> Signup and view all the answers

    What is a central step for engineering intelligent seamless therapeutics according to the passage?

    <p>Understanding the biofunctions of BBB for targeted drug delivery</p> Signup and view all the answers

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