Blood-Brain Barrier in Drug Delivery and Brain Tumors Targeting

Brain capillary endothelial cells (BCECs) form unique biological structure and architecture in association with astrocytes and pericytes, in which microenvironment the BCECs express restrictive tight junctional complexes that block the paracellular inward/outward traverse of biomolecules/compounds. These cells selectively/specifically control the transportation process through carrier and/or receptor mediated transport machineries that can also be exploited for the delivery of pharmaceuticals into the ______

BioImpacts, 2012, 2(1), 5-22 doi: 10.5681/bi.2012.002 http://bi.tbzmed.ac.ir/ Impacts of Blood-Brain Barrier in Drug Delivery and Targeting of Brain Tumors Yadollah Omidi* and Jaleh Barar Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ARTICLE INFO ABSTR ACT Article Type: Review Article Introduction: Entry of blood circulating agents into the ______ is highly selectively controlled by specific transport machineries at the blood brain barrier (BBB), whose excellent barrier restrictiveness make brain drug delivery and targeting very challenging.

Entry of blood circulating agents into the ______ is highly selectively controlled by specific transport machineries at the blood brain barrier (BBB), whose excellent barrier restrictiveness make brain drug delivery and targeting very challenging.

Impacts of Blood-Brain Barrier in Drug Delivery and Targeting of Brain Tumors Yadollah Omidi* and Jaleh Barar Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ARTICLE INFO ABSTR ACT Article Type: Review Article Introduction: Entry of blood circulating agents into the brain is highly selectively controlled by specific transport machineries at the blood brain barrier (BBB), whose excellent barrier restrictiveness make ______ drug delivery and targeting very challenging.

These cells selectively/specifically control the transportation process through carrier and/or receptor mediated transport machineries that can also be exploited for the delivery of pharmaceuticals into the ______

Brain capillary endothelial cells (BCECs) form unique biological structure and architecture in association with astrocytes and pericytes, in which microenvironment the BCECs express restrictive tight junctional complexes that block the paracellular inward/outward traverse of biomolecules/compounds. These cells selectively/specifically control the transportation process through carrier and/or receptor mediated transport machineries that can also be exploited for the delivery of pharmaceuticals into the