36 Questions
Which type of antithrombotic drug attenuates fibrin clot formation by blocking fibrin crosslinking?
Coagulants
What is the role of Tissue Plasminogen Activator (t-PA) in the fibrinolytic process?
It breaks down fibrin clots
What do antiplatelet agents inhibit?
Aggregation of platelets
Which class of agents does Tirofiban belong to?
Fibrinogen inhibitors
What is the mechanism of action of Vorapaxar?
Inhibition of protease-activated receptor-1
Which enzyme metabolizes Vorapaxar?
CYP3A enzymes
Which enzyme is responsible for converting plasminogen to plasmin?
t-PA
Which thrombolytic agent does not require t-PA for activation?
Streptokinase
Which thrombolytic agent has a longer active lifetime in the body compared to Streptokinase?
Anistreplase
Which thrombolytic agent has a reduced fibrin binding selectivity due to the removal of the first 172 amino acids?
Reteplase
Which enzyme produces thromboxane A2 (TXA2) in platelets?
Cyclooxygenase
What is the major product of cyclooxygenase in platelets?
Thromboxane A2 (TXA2)
Which receptor responds to thrombin in platelets?
PAR-1
What is the action of aspirin on cyclooxygenase1 (COX-1)?
Irreversible inhibition
Which of the following drugs increases the amount of active form of protein kinase A (PKA) present in platelets, leading to inhibition of platelet aggregation?
Dipyridamole
Which of the following drugs inhibits the activation of myosin light-chain kinase, resulting in vasodilation?
Dipyridamole
Which of the following drugs blocks PDE-mediated degradation of cAMP, leading to increased levels of cAMP?
Cilostazol
Which of the following drugs irreversibly modifies the platelet ADP receptor, blocking ADP-mediated activation of the GPIIb/IIIa complex and inhibiting platelet aggregation?
Clopidogrel
Which enzyme inhibits the action of t-PA by forming a complex with it?
α2-antiplasmin
Which of the following thrombolytic agents does not require t-PA for activation?
Streptokinase
Which thrombolytic agent has the longest half-life?
Alteplase
Which thrombolytic agent has reduced fibrin binding selectivity?
Reteplase
Which drug is a cyclic peptide/peptide mimic that is more stable to proteases and peptidases than linear peptides?
Tirofiban
Which drug competitively binds to the RGD binding sites in the GPIIb/IIIa complex, inhibiting fibrinogen-GPIIb/IIIa complex interactions and blocking platelet aggregation?
Tirofiban
Which drug is an analog of an alkaloid natural product (Himbacine) isolated from the bark of Australian magnolias?
Vorapaxar
Which of the following drugs inhibits the activation of myosin light-chain kinase, resulting in vasodilation?
None of the above
Which enzyme produces thromboxane A2 (TXA2) in platelets?
Cyclooxygenase-1 (COX-1)
What is the major product of cyclooxygenase in platelets?
Thromboxane A2 (TXA2)
Which of the following is an irreversible inhibitor of cyclooxygenase-1 (COX-1) and has additional actions that inhibit platelet aggregation and increase vasodilation?
Triflusal
Which of the following is NOT a receptor involved in platelet adhesion and aggregation?
PAR-1
Which of the following drugs irreversibly inhibits the production of thromboxane A2 (TXA2) in platelets?
Aspirin
Which of the following drugs is a bispecific factor IXa- and factor X-directed antibody used to activate the natural coagulation cascade and restore the blood clotting process for those with hemophilia A?
Emicizumab
Which of the following drugs inhibits the breakdown of cAMP in platelets and blood?
Dipyridamole
Which drug irreversibly modifies the platelet ADP receptor, blocking ADP-mediated activation of the GPIIb/IIIa complex and inhibiting platelet aggregation?
Clopidogrel
Which drug is a reversible inhibitor of P2Y12 receptors and binds at a site different from ADP, making it an allosteric antagonist?
Ticagrelor
Which drug is the Fab fragment of a monoclonal antibody that binds to the GPIIb/IIIa complex on the platelet surface, inhibiting the GPIIb/IIIa - fibrinogen interaction and blocking platelet aggregation?
Abciximab
Test your knowledge on bleeding prevention and treatments! This quiz covers topics such as trauma post-partum bleeding, dental work, and the use of tranexamic acid in mouthwash form. Explore the replacement of coagulation factors and learn about Emicizumab (Hemlibra), a groundbreaking treatment for hemophilia A. Challenge yourself and become an expert in bleeding prevention and management.
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