Podcast
Questions and Answers
Which type of antithrombotic drug attenuates fibrin clot formation by blocking fibrin crosslinking?
Which type of antithrombotic drug attenuates fibrin clot formation by blocking fibrin crosslinking?
What is the role of Tissue Plasminogen Activator (t-PA) in the fibrinolytic process?
What is the role of Tissue Plasminogen Activator (t-PA) in the fibrinolytic process?
What do antiplatelet agents inhibit?
What do antiplatelet agents inhibit?
Which class of agents does Tirofiban belong to?
Which class of agents does Tirofiban belong to?
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What is the mechanism of action of Vorapaxar?
What is the mechanism of action of Vorapaxar?
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Which enzyme metabolizes Vorapaxar?
Which enzyme metabolizes Vorapaxar?
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Which enzyme is responsible for converting plasminogen to plasmin?
Which enzyme is responsible for converting plasminogen to plasmin?
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Which thrombolytic agent does not require t-PA for activation?
Which thrombolytic agent does not require t-PA for activation?
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Which thrombolytic agent has a longer active lifetime in the body compared to Streptokinase?
Which thrombolytic agent has a longer active lifetime in the body compared to Streptokinase?
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Which thrombolytic agent has a reduced fibrin binding selectivity due to the removal of the first 172 amino acids?
Which thrombolytic agent has a reduced fibrin binding selectivity due to the removal of the first 172 amino acids?
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Which enzyme produces thromboxane A2 (TXA2) in platelets?
Which enzyme produces thromboxane A2 (TXA2) in platelets?
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What is the major product of cyclooxygenase in platelets?
What is the major product of cyclooxygenase in platelets?
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Which receptor responds to thrombin in platelets?
Which receptor responds to thrombin in platelets?
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What is the action of aspirin on cyclooxygenase1 (COX-1)?
What is the action of aspirin on cyclooxygenase1 (COX-1)?
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Which of the following drugs increases the amount of active form of protein kinase A (PKA) present in platelets, leading to inhibition of platelet aggregation?
Which of the following drugs increases the amount of active form of protein kinase A (PKA) present in platelets, leading to inhibition of platelet aggregation?
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Which of the following drugs inhibits the activation of myosin light-chain kinase, resulting in vasodilation?
Which of the following drugs inhibits the activation of myosin light-chain kinase, resulting in vasodilation?
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Which of the following drugs blocks PDE-mediated degradation of cAMP, leading to increased levels of cAMP?
Which of the following drugs blocks PDE-mediated degradation of cAMP, leading to increased levels of cAMP?
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Which of the following drugs irreversibly modifies the platelet ADP receptor, blocking ADP-mediated activation of the GPIIb/IIIa complex and inhibiting platelet aggregation?
Which of the following drugs irreversibly modifies the platelet ADP receptor, blocking ADP-mediated activation of the GPIIb/IIIa complex and inhibiting platelet aggregation?
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Which enzyme inhibits the action of t-PA by forming a complex with it?
Which enzyme inhibits the action of t-PA by forming a complex with it?
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Which of the following thrombolytic agents does not require t-PA for activation?
Which of the following thrombolytic agents does not require t-PA for activation?
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Which thrombolytic agent has the longest half-life?
Which thrombolytic agent has the longest half-life?
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Which thrombolytic agent has reduced fibrin binding selectivity?
Which thrombolytic agent has reduced fibrin binding selectivity?
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Which drug is a cyclic peptide/peptide mimic that is more stable to proteases and peptidases than linear peptides?
Which drug is a cyclic peptide/peptide mimic that is more stable to proteases and peptidases than linear peptides?
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Which drug competitively binds to the RGD binding sites in the GPIIb/IIIa complex, inhibiting fibrinogen-GPIIb/IIIa complex interactions and blocking platelet aggregation?
Which drug competitively binds to the RGD binding sites in the GPIIb/IIIa complex, inhibiting fibrinogen-GPIIb/IIIa complex interactions and blocking platelet aggregation?
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Which drug is an analog of an alkaloid natural product (Himbacine) isolated from the bark of Australian magnolias?
Which drug is an analog of an alkaloid natural product (Himbacine) isolated from the bark of Australian magnolias?
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Which of the following drugs inhibits the activation of myosin light-chain kinase, resulting in vasodilation?
Which of the following drugs inhibits the activation of myosin light-chain kinase, resulting in vasodilation?
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Which enzyme produces thromboxane A2 (TXA2) in platelets?
Which enzyme produces thromboxane A2 (TXA2) in platelets?
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What is the major product of cyclooxygenase in platelets?
What is the major product of cyclooxygenase in platelets?
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Which of the following is an irreversible inhibitor of cyclooxygenase-1 (COX-1) and has additional actions that inhibit platelet aggregation and increase vasodilation?
Which of the following is an irreversible inhibitor of cyclooxygenase-1 (COX-1) and has additional actions that inhibit platelet aggregation and increase vasodilation?
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Which of the following is NOT a receptor involved in platelet adhesion and aggregation?
Which of the following is NOT a receptor involved in platelet adhesion and aggregation?
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Which of the following drugs irreversibly inhibits the production of thromboxane A2 (TXA2) in platelets?
Which of the following drugs irreversibly inhibits the production of thromboxane A2 (TXA2) in platelets?
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Which of the following drugs is a bispecific factor IXa- and factor X-directed antibody used to activate the natural coagulation cascade and restore the blood clotting process for those with hemophilia A?
Which of the following drugs is a bispecific factor IXa- and factor X-directed antibody used to activate the natural coagulation cascade and restore the blood clotting process for those with hemophilia A?
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Which of the following drugs inhibits the breakdown of cAMP in platelets and blood?
Which of the following drugs inhibits the breakdown of cAMP in platelets and blood?
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Which drug irreversibly modifies the platelet ADP receptor, blocking ADP-mediated activation of the GPIIb/IIIa complex and inhibiting platelet aggregation?
Which drug irreversibly modifies the platelet ADP receptor, blocking ADP-mediated activation of the GPIIb/IIIa complex and inhibiting platelet aggregation?
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Which drug is a reversible inhibitor of P2Y12 receptors and binds at a site different from ADP, making it an allosteric antagonist?
Which drug is a reversible inhibitor of P2Y12 receptors and binds at a site different from ADP, making it an allosteric antagonist?
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Which drug is the Fab fragment of a monoclonal antibody that binds to the GPIIb/IIIa complex on the platelet surface, inhibiting the GPIIb/IIIa - fibrinogen interaction and blocking platelet aggregation?
Which drug is the Fab fragment of a monoclonal antibody that binds to the GPIIb/IIIa complex on the platelet surface, inhibiting the GPIIb/IIIa - fibrinogen interaction and blocking platelet aggregation?
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