Biological Profiles and GWAS in Polymorphisms
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Questions and Answers

What potential benefit does the inclusion of environmental measures of stress experience have in detecting functional polymorphic variants?

Aid in detecting polymorphic variants associated with individual differences under certain circumstances.

How can investigators leverage the increasing economy of genome-wide genotyping in their research?

Collect DNA for pooling with other investigators for GWAS analyses and/or candidate gene investigations.

What recent developments in gene transcription and translation are expected to impact genetic research?

Recent developments in understanding gene transcription and translation.

What has recent work shown in terms of sequence differences between RNA and DNA?

<p>Widespread sequence differences between RNA and DNA.</p> Signup and view all the answers

How can gene transcripts be influenced according to emerging eQTL research?

<p>Influenced by multiple and even distal genomic regions.</p> Signup and view all the answers

What has been observed in terms of the heritability of epigenetic fingerprints?

<p>Epigenetic fingerprints are heritable.</p> Signup and view all the answers

What is the importance of replicating epistatic relationships in neurogenetics studies?

<p>To address statistical instability due to small genotype combinations</p> Signup and view all the answers

Why are large-scale neurogenetics studies necessary?

<p>To provide adequate statistical power for studying epistatic interactions</p> Signup and view all the answers

How do additive genetic effects influence emergent biological and behavioral phenotypes?

<p>They may dominate variability even in the presence of epistatic interactions at the gene level</p> Signup and view all the answers

What do biologically informed multilocus profiles represent in neurogenetics research?

<p>The cumulative effect of multiple polymorphic loci on specific signaling mechanisms</p> Signup and view all the answers

How did five functional dopaminergic polymorphisms contribute to variance in reward-related ventral striatal reactivity?

<p>They predicted 11% of the variance</p> Signup and view all the answers

What is the potential benefit of using profile scores in neurogenetics research?

<p>To better characterize genetically driven variability in overall signaling</p> Signup and view all the answers

What are the limitations of the approach based on functional understanding of polymorphisms?

<p>Majority have unknown functional consequences or have not been well replicated.</p> Signup and view all the answers

How can data-driven profiles from genome-wide association studies (GWASs) complement biologically informed profiles?

<p>By providing additional information and insights.</p> Signup and view all the answers

What is the purpose of hypothesized gene-group analyses in the context of polymorphisms?

<p>To cluster polymorphisms of unknown biological function within genes of similar function.</p> Signup and view all the answers

Why do multilocus approaches emphasize the polygenic nature of complex traits?

<p>To highlight the small effects conferred by single polymorphisms.</p> Signup and view all the answers

How can novel statistical approaches like regression trees and machine learning contribute to understanding genetic interactions?

<p>By identifying genetic interactions empirically, without hypotheses.</p> Signup and view all the answers

What do functional genetic polymorphisms represent in terms of individual differences in brain chemistry?

<p>Individual differences in brain chemistry and neural signaling pathways.</p> Signup and view all the answers

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