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Cancer Therapy and Hematopoietic Stem Cell Transplantation: Gene Polymorphisms and Immunity

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Cancer Therapy and Hematopoietic Stem Cell Transplantation: Gene Polymorphisms and Immunity

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Questions and Answers

What is a consequence of transplantation, especially of hematopoietic stem cells?

Defects in host immunity due to graft-versus-host disease (correct)

Immune system recovery

Enhanced host immunity

Increased susceptibility to bacterial infections

How do purine analogues and monoclonal antibodies contribute to impaired immunity?

By increasing phagocytosis of bacteria

By enhancing humoral immunity

By stimulating the innate immune system

By inducing neutropenia or deficient cellular immunity (correct)

What is a factor that influences individual susceptibility to infection?

Dose of immunosuppressive therapy

Type of antibiotic used

Type of malignancy being treated

Genetic makeup of the host (correct)

What is a component of the immune system that is believed to survive chemotherapy?

Innate immune system Signup and view all the answers

What is a consequence of impaired humoral immunity?

Defective opsonization and phagocytosis of bacteria Signup and view all the answers

Why do tyrosine kinase inhibitors (TKIs) and inhibitors of phosphatidylinositol 3 kinase (PI3K) contribute to impaired immunity?

By inducing neutropenia or deficient cellular immunity Signup and view all the answers

What determines which components of the immune system become most important in a specific context of immune deficiency?

Specific context of the immune deficiency Signup and view all the answers

What is a consequence of graft-versus-host disease (GVHD)?

Defects in host immunity Signup and view all the answers

Why do genetic polymorphisms in immune genes influence individual susceptibility to infection?

Because of their influence on functional changes in immune genes Signup and view all the answers

What is a consequence of treatment with immunosuppressive therapy?