Lecture 20
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Questions and Answers

What is the correct order of organization in multicellular organisms?

  • Tissues → Organs → Organ Systems → Body → Cells
  • Body → Organ Systems → Organs → Tissues → Cells
  • Cells → Tissues → Organs → Organ Systems → Body (correct)
  • Organs → Tissues → Cells → Body

What is the main component of animal connective tissues?

  • Extracellular matrix (correct)
  • Collagen fibrils
  • Osteocytes
  • Cells

What is the main function of collagen in animal connective tissues?

  • Providing tensile strength (correct)
  • Providing cushioning
  • Providing flexibility
  • Providing structural support

What type of modification occurs to collagen during its synthesis?

<p>Glycosylation and acetylation (A)</p> Signup and view all the answers

What is the precursor to collagen?

<p>Procollagen (C)</p> Signup and view all the answers

Why doesn't procollagen proteinase cleave procollagen inside the fibroblast?

<p>Because the unstructured ends of procollagen prevent proteinase activity (D)</p> Signup and view all the answers

What happens to epithelial cells when apical bundles of actin filaments contract?

<p>They narrow at their apex (B)</p> Signup and view all the answers

What is the fate of a vesicle in a developing animal?

<p>Its fate depends on the orientation of contraction of the epithelial sheet (C)</p> Signup and view all the answers

What type of proteins binds to the dense plaque of intracellular linker proteins on the cytoplasmic side of the plasma membrane?

<p>Cadherin proteins (A)</p> Signup and view all the answers

What is the function of hemidesmosomes in an epithelial cell?

<p>To anchor the intermediate filaments to the basal lamina (A)</p> Signup and view all the answers

Why are integrins used in hemidesmosomes instead of cadherins?

<p>Because integrins are specific to the basal lamina (C)</p> Signup and view all the answers

What is the earliest tube that forms in a developing embryo?

<p>Neural tube (D)</p> Signup and view all the answers

How do integrins inform the cell that it is anchored to the extracellular matrix?

<p>By undergoing a conformational change (C)</p> Signup and view all the answers

What triggers the switch to an active conformation in integrins?

<p>Binding to fibronectin or intracellular adaptor proteins (C)</p> Signup and view all the answers

What do polysaccharides and proteins in tissues do, according to the text?

<p>Fill spaces and resist compression (C)</p> Signup and view all the answers

What is the role of glycosaminoglycans (GAGs) in tissues?

<p>Fulfilling the role of resisting compression (D)</p> Signup and view all the answers

What characterizes Hyaluronan as a glycosaminoglycan?

<p>Consists of a single long chain with up to 25,000 repeated disaccharide units (C)</p> Signup and view all the answers

Why are the negative charges on glycosaminoglycans (GAGs) important to their function?

<p>Affect the interaction with other extracellular matrix components (C)</p> Signup and view all the answers

What is a characteristic of oncogenes?

<p>They act in a dominant manner. (C)</p> Signup and view all the answers

What happens to the function of tumor suppressor genes in cancer cells?

<p>It is lost. (C)</p> Signup and view all the answers

What is a common feature of the key regulatory pathways perturbed in human cancers?

<p>They regulate cell growth and proliferation. (B)</p> Signup and view all the answers

What type of mutations can convert a proto-oncogene into an oncogene?

<p>Gain-of-function mutations. (C)</p> Signup and view all the answers

What is a characteristic of tumor suppressor genes?

<p>They generally act in a recessive manner. (C)</p> Signup and view all the answers

What is the result of a loss-of-function mutation in a tumor suppressor gene?

<p>The function of the gene is lost. (B)</p> Signup and view all the answers

What do gap junctions provide neighboring cells with?

<p>Direct channel of intercytosolic communication (B)</p> Signup and view all the answers

Which protein assemblies penetrate the apposed membranes of adjacent cells in gap junctions?

<p>Connexons (B)</p> Signup and view all the answers

What do stem cells have the ability to do in terms of lineage production?

<p>Renew themselves and produce terminally differentiated lineages (B)</p> Signup and view all the answers

Where does renewal occur continuously in the mammalian intestine?

<p>In the epithelial lining (D)</p> Signup and view all the answers

What type of cells are primarily renewed from stem cells in the epidermis?

<p>Keratinocyte stem cells (B)</p> Signup and view all the answers

Which type of stem cells are found in red bone marrow and give rise to various blood cell types?

<p>Hemopoietic stem cells (A)</p> Signup and view all the answers

What maintains the proliferation of stem cells in the precursor cells of the intestinal crypts?

<p>Wnt signaling pathway (B)</p> Signup and view all the answers

What protein interacts with the GPCR frizzled in the Wnt signaling pathway?

<p>Dishevelled (C)</p> Signup and view all the answers

Which cell types increase in production during an infection due to hemopoietic stem cells?

<p>White blood cells (leukocytes) (A)</p> Signup and view all the answers

What allows stem cells of different types to be maintained in culture?

<p>Culturing techniques (C)</p> Signup and view all the answers

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