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Bile Acid Sequestrants Mechanism of Action

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Bile Acid Sequestrants Mechanism of Action

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Questions and Answers

Which characteristic of bile acid sequestrants (BAS) explains their need to be basic and cationic?

They cause reduction of LDL-C in a dose-dependent manner

They are not absorbed and excreted in stool post-binding

They bind to bile acids in the small intestine for fecal elimination

Bile acids are acidic and anionic in nature (correct)

Why does colestipol require an acidic pH to become protonated and have binding power?

It contains a positive charge

It has tertiary amine and no positive charge (correct)

It is absorbed in the small intestine

It is excreted in stool post-binding

Which adverse effect is associated with bile acid sequestrants (BAS)?

Hypertension

Heartburn (correct)

Infertility

Increased coagulation

What type of drug interaction is recommended for bile acid sequestrants (BAS)?

Take drugs 1 hour after taking bile sequestrants Signup and view all the answers

What is the primary role of liver cholesterol synthesis in the context of bile acid sequestrants (BAS)?

Increase synthesis of LDL-receptors Signup and view all the answers

What is the main reason for the contraindication of bile acid sequestrants (BAS) in severe hypertriglyceridemia?

They impair coagulation Signup and view all the answers

Bile Acid Sequestrants Mechanism of Action

Choose a study mode

Podcast

Questions and Answers

Which characteristic of bile acid sequestrants (BAS) explains their need to be basic and cationic?

Why does colestipol require an acidic pH to become protonated and have binding power?

Which adverse effect is associated with bile acid sequestrants (BAS)?

What type of drug interaction is recommended for bile acid sequestrants (BAS)?

What is the primary role of liver cholesterol synthesis in the context of bile acid sequestrants (BAS)?

What is the main reason for the contraindication of bile acid sequestrants (BAS) in severe hypertriglyceridemia?

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