6 Questions
Which characteristic of bile acid sequestrants (BAS) explains their need to be basic and cationic?
Bile acids are acidic and anionic in nature
Why does colestipol require an acidic pH to become protonated and have binding power?
It has tertiary amine and no positive charge
Which adverse effect is associated with bile acid sequestrants (BAS)?
Heartburn
What type of drug interaction is recommended for bile acid sequestrants (BAS)?
Take drugs 1 hour after taking bile sequestrants
What is the primary role of liver cholesterol synthesis in the context of bile acid sequestrants (BAS)?
Increase synthesis of LDL-receptors
What is the main reason for the contraindication of bile acid sequestrants (BAS) in severe hypertriglyceridemia?
They impair coagulation
Learn about the mechanism of action of bile acid sequestrants (BAS), which are anion-exchange resins that bind to bile acids in the small intestine for fecal elimination. Understand why this process is important for cholesterol metabolism and how it affects liver cholesterol synthesis and LDL-receptor endocytosis.
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