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Questions and Answers
Which characteristic of bile acid sequestrants (BAS) explains their need to be basic and cationic?
Which characteristic of bile acid sequestrants (BAS) explains their need to be basic and cationic?
- They cause reduction of LDL-C in a dose-dependent manner
- They are not absorbed and excreted in stool post-binding
- They bind to bile acids in the small intestine for fecal elimination
- Bile acids are acidic and anionic in nature (correct)
Why does colestipol require an acidic pH to become protonated and have binding power?
Why does colestipol require an acidic pH to become protonated and have binding power?
- It contains a positive charge
- It has tertiary amine and no positive charge (correct)
- It is absorbed in the small intestine
- It is excreted in stool post-binding
Which adverse effect is associated with bile acid sequestrants (BAS)?
Which adverse effect is associated with bile acid sequestrants (BAS)?
- Hypertension
- Heartburn (correct)
- Infertility
- Increased coagulation
What type of drug interaction is recommended for bile acid sequestrants (BAS)?
What type of drug interaction is recommended for bile acid sequestrants (BAS)?
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What is the primary role of liver cholesterol synthesis in the context of bile acid sequestrants (BAS)?
What is the primary role of liver cholesterol synthesis in the context of bile acid sequestrants (BAS)?
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What is the main reason for the contraindication of bile acid sequestrants (BAS) in severe hypertriglyceridemia?
What is the main reason for the contraindication of bile acid sequestrants (BAS) in severe hypertriglyceridemia?
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