18 Questions
What is the fate of chylomicron remnants in the liver?
They are stored, oxidized to bile acids, or secreted in the bile
What is the role of lipoprotein lipase in triglyceride regulation?
It hydrolyzes triglycerides in chylomicrons and VLDL into FFA
What is the primary function of inhibitors of intestinal cholesterol absorption?
To reduce cholesterol absorption in the gut
What is the primary mechanism of action of cholestyramine and colestipol?
Forming complexes with bile acids in the intestine
What happens to cholesterol in LDL?
It is utilized by tissues, returns to the liver, or deposited in blood vessels
What is the therapeutic use of nicotinic acid?
Hypertriglyceridemia
What is the primary goal of non-drug therapy for hyperlipidemia?
To modify lifestyle through diet control, weight reduction, and exercise
What is the effect of HMG-CoA reductase inhibitors on cholesterol synthesis?
Decrease
What is the effect of fibric acid derivatives on peripheral catabolism of VLDL and chylomicrons?
Increase
What is the class of drugs that include Atorvastatin, Simvastatin, and Lovastatin?
HMG-CoA reductase inhibitors
What is the potential adverse effect of combining statins with fibrates?
Increased risk of myopathy
What is the effect of cholestyramine and colestipol on the absorption of fat-soluble vitamins?
Decrease
What is the primary function of high density lipoproteins (HDLs) in the blood?
To collect fat from cells and tissues and return it to the liver
What is the main component of chylomicrons?
Triglycerides
What is the purpose of apolipoproteins in lipid transport?
To facilitate the transport of lipids through the bloodstream
What is the term for an excess of fatty substances called lipids in the blood?
Hyperlipoproteinemia
What is the transitional form between chylomicrons and low-density lipoproteins?
Intermediate density lipoproteins (IDLs)
What is the site of production of chylomicrons?
Intestine
This quiz covers the mechanism of action, therapeutic uses, and adverse effects of bile acid sequestrants like cholestyramine and colestipol, as well as HMG-CoA reductase inhibitors (statins) like atorvastatin and simvastatin.
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