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Pharmacology: Bile Acid Sequestrants and Statins

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Pharmacology: Bile Acid Sequestrants and Statins

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Questions and Answers

What is the fate of chylomicron remnants in the liver?

They are converted into LDL

They are transported back into the bloodstream

They are further metabolized into VLDL

They are stored, oxidized to bile acids, or secreted in the bile (correct)

What is the role of lipoprotein lipase in triglyceride regulation?

It oxidizes cholesterol to bile acids

It hydrolyzes triglycerides in chylomicrons and VLDL into FFA (correct)

It converts LDL into HDL

It assembles cholesterol and triglycerides into VLDL

What is the primary function of inhibitors of intestinal cholesterol absorption?

To reduce cholesterol absorption in the gut (correct)

To increase triglyceride synthesis

To oxidize cholesterol to bile acids

To increase VLDL production

What is the primary mechanism of action of cholestyramine and colestipol?

Forming complexes with bile acids in the intestine Signup and view all the answers

What happens to cholesterol in LDL?

It is utilized by tissues, returns to the liver, or deposited in blood vessels Signup and view all the answers

What is the therapeutic use of nicotinic acid?

Hypertriglyceridemia Signup and view all the answers

What is the primary goal of non-drug therapy for hyperlipidemia?

To modify lifestyle through diet control, weight reduction, and exercise Signup and view all the answers

What is the effect of HMG-CoA reductase inhibitors on cholesterol synthesis?

Decrease Signup and view all the answers

What is the effect of fibric acid derivatives on peripheral catabolism of VLDL and chylomicrons?

Increase Signup and view all the answers

What is the class of drugs that include Atorvastatin, Simvastatin, and Lovastatin?

HMG-CoA reductase inhibitors Signup and view all the answers

What is the potential adverse effect of combining statins with fibrates?

Increased risk of myopathy Signup and view all the answers

What is the effect of cholestyramine and colestipol on the absorption of fat-soluble vitamins?

Decrease Signup and view all the answers

What is the primary function of high density lipoproteins (HDLs) in the blood?

To collect fat from cells and tissues and return it to the liver Signup and view all the answers

What is the main component of chylomicrons?

Triglycerides Signup and view all the answers

What is the purpose of apolipoproteins in lipid transport?

To facilitate the transport of lipids through the bloodstream Signup and view all the answers

What is the term for an excess of fatty substances called lipids in the blood?

Hyperlipoproteinemia Signup and view all the answers

What is the transitional form between chylomicrons and low-density lipoproteins?

Intermediate density lipoproteins (IDLs) Signup and view all the answers

What is the site of production of chylomicrons?

Intestine Signup and view all the answers