5 Questions
What is the main function of the hinge region in a B cell receptor (BCR)?
Allowing for flexibility and mobility of the antigen-binding Fab regions
How does the presence of disulfide bonds in the hinge region contribute to the BCR structure?
Contributes to the stability of the BCR structure
Which statement accurately describes the variability of the hinge region among different BCRs?
Variability of the hinge region contributes to antigen recognition specificity
How does the hinge region influence B cell activation and subsequent immune responses?
By transmitting signals from the antigen-binding site to intracellular signaling domains
What is the role of the hinge region in interacting with effector molecules of the immune system?
Interacting with complement proteins and Fc receptors on other immune cells
Study Notes
B Cell Receptor (BCR) Hinge Region
- The main function of the hinge region in a B cell receptor (BCR) is to provide flexibility and maintain the correct distance between the antigen-binding site and the cell membrane.
Hinge Region Structure
- Disulfide bonds in the hinge region contribute to the BCR structure by stabilizing the region and maintaining the overall conformation of the receptor.
Variability of the Hinge Region
- The hinge region exhibits variability among different BCRs, with some BCRs having a longer or shorter hinge region, which affects the receptor's flexibility and function.
B Cell Activation and Immune Responses
- The hinge region influences B cell activation and subsequent immune responses by modulating the receptor's ability to bind antigens and trigger downstream signaling pathways.
Interaction with Effector Molecules
- The hinge region plays a crucial role in interacting with effector molecules of the immune system, such as complement proteins, Fc receptors, and antibody-dependent cellular cytotoxicity (ADCC) molecules, facilitating the elimination of pathogens.
Test your knowledge on the structure of B cell receptors (BCRs) by identifying correct statements about the hinge region. Learn about the flexible segment connecting the antigen-binding Fab regions to the transmembrane region of the receptor.
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