Questions and Answers
What type of drug is Baclofen (Lioresal)?
What is the mechanism of action for Baclofen (Lioresal)?
Depresses monosynaptic and polysynaptic afferent reflex activity at the spinal cord level and stimulates GABA receptors.
What is Baclofen (Lioresal) used for?
Used to treat muscle spasms associated with multiple sclerosis (MS) and spinal cord injuries.
What are the side effects of Baclofen (Lioresal)?
Signup and view all the answers
What is the pregnancy category for Baclofen (Lioresal)?
Signup and view all the answers
Patients with what types of conditions are contraindicated for Baclofen (Lioresal)?
Signup and view all the answers
What drug interactions are indicated for Baclofen (Lioresal)?
Signup and view all the answers
What are the unlabeled uses of Baclofen (Lioresal)?
Signup and view all the answers
Study Notes
Baclofen (Lioresal) Overview
- Baclofen is a centrally-acting skeletal muscle relaxant.
- Functions as a GABA agonist, enhancing inhibitory neurotransmission.
Mechanism of Action
- Acts primarily in the spinal cord to reduce both monosynaptic and polysynaptic reflex activity.
- Stimulates GABA receptors, leading to decreased excitatory neurotransmission and muscle relaxation.
Indications
- Primarily prescribed for muscle spasms related to multiple sclerosis (MS).
- Also effective for muscle spasms resulting from spinal cord injuries.
Side Effects
- Common adverse reactions include drowsiness, vertigo, and confusion.
- Other potential effects are fatigue, headache, multiple organ system failure, and in severe cases, death.
Pregnancy Considerations
- Classified as a Pregnancy Category C drug, indicating potential risks during pregnancy that warrant caution.
Contraindications
- Not recommended for patients with coagulopathy or bacteremia.
- Avoid use in individuals requiring intramuscular or intrathecal administration.
- Contraindicated for pregnant or lactating women.
Drug Interactions
- Risk of compounded CNS depression when combined with alcohol, CNS depressants, MAO inhibitors, and certain antihistamines.
- Can lead to increased glucose levels, possibly necessitating insulin dosage adjustments.
Unlabeled Uses
- Occasionally used for managing trigeminal neuralgia.
- May be effective for tardive dystonia related to antipsychotic medications.
- Sometimes prescribed for chronic pain management.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
This quiz provides a comprehensive overview of Baclofen, a skeletal muscle relaxant. It covers its mechanism of action, indications, side effects, and important considerations during pregnancy. Test your knowledge about this medication and its effects on muscle spasticity.
