Baclofen Overview and Mechanism of Action

Study Notes

Baclofen (Lioresal) Overview

Baclofen is a centrally-acting skeletal muscle relaxant.
Functions as a GABA agonist, enhancing inhibitory neurotransmission.

Mechanism of Action

Acts primarily in the spinal cord to reduce both monosynaptic and polysynaptic reflex activity.
Stimulates GABA receptors, leading to decreased excitatory neurotransmission and muscle relaxation.

Indications

Primarily prescribed for muscle spasms related to multiple sclerosis (MS).
Also effective for muscle spasms resulting from spinal cord injuries.

Side Effects

Common adverse reactions include drowsiness, vertigo, and confusion.
Other potential effects are fatigue, headache, multiple organ system failure, and in severe cases, death.

Pregnancy Considerations

Classified as a Pregnancy Category C drug, indicating potential risks during pregnancy that warrant caution.

Contraindications

Not recommended for patients with coagulopathy or bacteremia.
Avoid use in individuals requiring intramuscular or intrathecal administration.
Contraindicated for pregnant or lactating women.

Drug Interactions

Risk of compounded CNS depression when combined with alcohol, CNS depressants, MAO inhibitors, and certain antihistamines.
Can lead to increased glucose levels, possibly necessitating insulin dosage adjustments.

Unlabeled Uses

Occasionally used for managing trigeminal neuralgia.
May be effective for tardive dystonia related to antipsychotic medications.
Sometimes prescribed for chronic pain management.

Description

This quiz provides a comprehensive overview of Baclofen, a skeletal muscle relaxant. It covers its mechanism of action, indications, side effects, and important considerations during pregnancy. Test your knowledge about this medication and its effects on muscle spasticity.