B lymphocytes and self antigens
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Questions and Answers

Which of the following is a possible outcome for B cells that recognize self antigens in peripheral lymphoid tissues without receiving T cell help?

  • They become anergic due to a block in signaling from the antigen receptor.
  • They undergo apoptosis.
  • They engage inhibitory receptors and prevent activation.
  • All of the above. (correct)

    • What is one hypothesis for why B cells become anergic when they recognize a protein antigen but do not receive T cell help?

  • The antigen receptor on the B cells is blocked from signaling. (correct)
  • The B cells lack the necessary survival stimuli.
  • The B cells are eliminated by regulatory T cells.
  • The B cells are excluded from the lymphoid follicles.

    • How do regulatory T cells contribute to B cell tolerance in peripheral lymphoid tissues?

  • They eliminate B cells that recognize self antigens.
  • They engage inhibitory receptors on B cells. (correct)
  • They prevent B cells from leaving the lymphoid follicles.
  • They provide necessary survival stimuli to B cells.

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