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Questions and Answers
Which of the following is a possible outcome for B cells that recognize self antigens in peripheral lymphoid tissues without receiving T cell help?
Which of the following is a possible outcome for B cells that recognize self antigens in peripheral lymphoid tissues without receiving T cell help?
- They become anergic due to a block in signaling from the antigen receptor.
- They undergo apoptosis.
- They engage inhibitory receptors and prevent activation.
- All of the above. (correct)
What is one hypothesis for why B cells become anergic when they recognize a protein antigen but do not receive T cell help?
What is one hypothesis for why B cells become anergic when they recognize a protein antigen but do not receive T cell help?
- The antigen receptor on the B cells is blocked from signaling. (correct)
- The B cells lack the necessary survival stimuli.
- The B cells are eliminated by regulatory T cells.
- The B cells are excluded from the lymphoid follicles.
How do regulatory T cells contribute to B cell tolerance in peripheral lymphoid tissues?
How do regulatory T cells contribute to B cell tolerance in peripheral lymphoid tissues?
- They eliminate B cells that recognize self antigens.
- They engage inhibitory receptors on B cells. (correct)
- They prevent B cells from leaving the lymphoid follicles.
- They provide necessary survival stimuli to B cells.
