Apoptosis and Self-Reactive Lymphocytes
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Questions and Answers

Which of the following is a likely mechanism of death of mature T lymphocytes induced by self antigens?

  • Antigen recognition induces the production of proapoptotic proteins (correct)
  • Antigen recognition induces the production of antiapoptotic proteins
  • Antigen recognition inhibits the production of caspases
  • Antigen recognition activates the production of growth factors

    • Which of the following is NOT a result of self antigens recognition?

  • Production of antiapoptotic proteins (correct)
  • Apoptosis
  • Elimination of self-reactive lymphocytes
  • Activation of caspases

    • Which receptor-ligand pair is involved in self-tolerance?

  • CD95 and FasL and Fas
  • FasL and Fas
  • CD95 and Fas
  • CD95 and FasL (correct)

    • Which of the following is a characteristic of self antigens that contribute to the induction of T cell tolerance?

    <p>Self antigens induce deletion and generate regulatory T cells in the thymus.</p> Signup and view all the answers

    Which of the following is a characteristic of microbial antigens that contribute to the activation of T cells?

    <p>Microbial antigens elicit innate immune reactions, leading to T cell proliferation and differentiation into effector cells.</p> Signup and view all the answers

    Which of the following is true about mutations in the genes encoding caspase-8 or -10?

    <p>Mutations in these genes are the only known examples of defects in apoptosis causing an autoimmune disorder.</p> Signup and view all the answers

    Which pathway of apoptosis is induced by self antigen recognition without costimulation?

    <p>Intrinsic pathway</p> Signup and view all the answers

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