7 Questions
Which of the following is a likely mechanism of death of mature T lymphocytes induced by self antigens?
Antigen recognition induces the production of proapoptotic proteins
Which of the following is NOT a result of self antigens recognition?
Production of antiapoptotic proteins
Which receptor-ligand pair is involved in self-tolerance?
CD95 and FasL
Which of the following is a characteristic of self antigens that contribute to the induction of T cell tolerance?
Self antigens induce deletion and generate regulatory T cells in the thymus.
Which of the following is a characteristic of microbial antigens that contribute to the activation of T cells?
Microbial antigens elicit innate immune reactions, leading to T cell proliferation and differentiation into effector cells.
Which of the following is true about mutations in the genes encoding caspase-8 or -10?
Mutations in these genes are the only known examples of defects in apoptosis causing an autoimmune disorder.
Which pathway of apoptosis is induced by self antigen recognition without costimulation?
Intrinsic pathway
Quiz: Understanding Apoptosis and Self-Reactive Lymphocytes Test your knowledge on the mechanisms of apoptosis triggered by recognition of self antigens in T lymphocytes. Learn about the production of proapoptotic proteins and the activation of mitochondrial proteins.
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