Immunologic Tolerance and Autoimmunity Quiz

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Questions and Answers

Which type of immunologic tolerance takes place in the primary lymphoid organs?

Peripheral tolerance
Active suppression
Central tolerance (correct)
Anergy

What is the purpose of immunologic tolerance?

To activate the immune system
To protect against autoimmunity (correct)
To induce apoptosis
To sequester self-Ag

What happens to self-reactive lymphocytes in peripheral tolerance?

Apoptosis
Active suppression by regulatory T cells
Anergy
All of the above (correct)

In which areas are self-antigens sequestered to prevent immune response?

<p>Immune-privileged areas (D)</p> Signup and view all the answers

When is peripheral tolerance used?

<p>Both A and B (D)</p> Signup and view all the answers

Flashcards

Central Tolerance

The process where the immune system learns to distinguish self from non-self during development in the thymus (T cells) and bone marrow (B cells).

Peripheral Tolerance

The process where the immune system learns to tolerate self-antigens after immune cells have matured and left the primary lymphoid organs.

Purpose of Immunologic Tolerance

To prevent the immune system from attacking the body's own tissues and cells, which would lead to autoimmune diseases.

Immune-privileged Areas

Specific tissues and organs that are isolated from the immune system, such as the eye and brain, where self-antigens are hidden to avoid immune attacks.

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Role of Peripheral Tolerance

To prevent the immune system from attacking self-antigens that are present in the periphery, but were not encountered during central tolerance.

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Study Notes

Central Tolerance

Takes place in the primary lymphoid organs: bone marrow and thymus
Ensures the body does not mount an immune response against its own tissues.
Occurs during the development of immune cells.

Purpose of Immunologic Tolerance

To prevent autoimmune diseases, where the body's immune system attacks its own tissues.

Peripheral Tolerance

Occurs in secondary lymphoid organs, after immune cells have matured.
Self-reactive lymphocytes that escape central tolerance can undergo apoptosis or become anergic.
Anergy refers to a state of unresponsiveness to stimulation.

Antigen Sequestration

Self-antigens in certain areas are hidden from the immune system to prevent self-reactivity.
Occurs in areas like the eye, brain, and testes.

Peripheral Tolerance Usage

Activated when self-reactive lymphocytes encounter self-antigens in the periphery.
This mechanism acts as a backup to central tolerance.

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Description

Test your knowledge on immunologic tolerance and autoimmunity with this quiz! Learn about the importance of self-tolerance in protecting against autoimmune diseases and the different types of immunologic tolerance.