Podcast
Questions and Answers
Which type of immunologic tolerance takes place in the primary lymphoid organs?
Which type of immunologic tolerance takes place in the primary lymphoid organs?
What is the purpose of immunologic tolerance?
What is the purpose of immunologic tolerance?
What happens to self-reactive lymphocytes in peripheral tolerance?
What happens to self-reactive lymphocytes in peripheral tolerance?
In which areas are self-antigens sequestered to prevent immune response?
In which areas are self-antigens sequestered to prevent immune response?
Signup and view all the answers
When is peripheral tolerance used?
When is peripheral tolerance used?
Signup and view all the answers
Study Notes
Central Tolerance
- Takes place in the primary lymphoid organs: bone marrow and thymus
- Ensures the body does not mount an immune response against its own tissues.
- Occurs during the development of immune cells.
Purpose of Immunologic Tolerance
- To prevent autoimmune diseases, where the body's immune system attacks its own tissues.
Peripheral Tolerance
- Occurs in secondary lymphoid organs, after immune cells have matured.
- Self-reactive lymphocytes that escape central tolerance can undergo apoptosis or become anergic.
- Anergy refers to a state of unresponsiveness to stimulation.
Antigen Sequestration
- Self-antigens in certain areas are hidden from the immune system to prevent self-reactivity.
- Occurs in areas like the eye, brain, and testes.
Peripheral Tolerance Usage
- Activated when self-reactive lymphocytes encounter self-antigens in the periphery.
- This mechanism acts as a backup to central tolerance.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge on immunologic tolerance and autoimmunity with this quiz! Learn about the importance of self-tolerance in protecting against autoimmune diseases and the different types of immunologic tolerance.
