25 Questions
What is the main function of Fc receptors in the immune system?
Phagocytosis enhancement
Which subclass of antibodies is NOT mentioned as being effective at complement fixation?
IgA
What is the primary role of NK cells in antibody-dependent cell-mediated cytotoxicity (ADCC)?
Cell killing
Which cells are primarily involved in antibody-dependent degranulation from granulocytes?
Eosinophils and basophils
Which type of antibodies are most important for neutralization to protect against infections?
IgG and IgM
What is one of the main roles of IgA antibodies in the body?
Neutralization in mucosal tissues
Which antibody class is widely distributed in the body, including to the developing fetus?
IgG
What is the primary function of Fc receptors on granulocytes in response to pathogens?
Degranulation
What is the main mechanism by which Fc receptors enhance phagocytosis of antigens by immune cells?
Crosslinking with antibodies bound to antigens
Which statement is true regarding IgD?
Promotes basophil and mast cell release of AMPs
What is the role of IgG in the immune system?
Is particularly good at complement fixation
What is the function of IgA in the body?
Is found in secretions and is effective at neutralizing toxins and pathogens
What is the primary role of IgE in the immune system?
Is best known for roles in allergy, asthma, and parasitic worm infection
Which pathway of the complement system relies on C1q binding to IgG and IgA antibodies?
Classical pathway
'Antibodies must be cross-linked in order for them to trigger an Fc receptor-mediated signal.' - Is this statement true or false?
True
Which antibody class is present at higher levels in secretions of the upper respiratory tract but is a tiny component of blood?
IgA
Which antibody class is the first antibody produced in a primary immune response and exhibits pentavalent opsonization?
IgM
Which mechanism results in the formation of the Membrane Attack Complex (MAC) to destroy target cells?
Complement Activation
Which antibody class is particularly effective at complement fixation, aiding in the destruction of pathogens?
IgA
Which antibody class plays a prominent role in allergic responses, asthma, and parasitic worm infections?
IgE
How does antibody-dependent cell-mediated cytotoxicity (ADCC) primarily lead to target cell death?
Induction of apoptosis by activation of NK cells
What is the main difference between IgM and IgG antibodies in initiating the complement cascade?
Number of antigen binding sites
Which cell type expresses receptors that can recognize the Fc portion of IgE and IgG antibodies, leading to specific immune responses?
Granulocytes
What is the primary function of Fc receptors on macrophages in response to antibody opsonization?
Promoting engulfment of antigens by phagocytosis
What is the main effector function of mast cells when activated by TH2 cytokines in response to pathogens?
Release of histamine and other molecules from granules
Explore how B cells opsonize through Fc receptors which are a family of cell surface receptors that bind to the Fc portion of Igs. Learn about the specificity of Fc receptors for different classes of immunoglobulins.
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