Lecture 8: B Cells
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Questions and Answers

What is the main function of Fc receptors in the immune system?

  • Cytokine production
  • Phagocytosis enhancement (correct)
  • Memory cell activation
  • Antigen presentation
  • Which subclass of antibodies is NOT mentioned as being effective at complement fixation?

  • IgG2
  • IgA (correct)
  • IgG1
  • IgG3
  • What is the primary role of NK cells in antibody-dependent cell-mediated cytotoxicity (ADCC)?

  • Antigen presentation
  • Cell killing (correct)
  • Histamine release
  • Cytokine secretion
  • Which cells are primarily involved in antibody-dependent degranulation from granulocytes?

    <p>Eosinophils and basophils</p> Signup and view all the answers

    Which type of antibodies are most important for neutralization to protect against infections?

    <p>IgG and IgM</p> Signup and view all the answers

    What is one of the main roles of IgA antibodies in the body?

    <p>Neutralization in mucosal tissues</p> Signup and view all the answers

    Which antibody class is widely distributed in the body, including to the developing fetus?

    <p>IgG</p> Signup and view all the answers

    What is the primary function of Fc receptors on granulocytes in response to pathogens?

    <p>Degranulation</p> Signup and view all the answers

    What is the main mechanism by which Fc receptors enhance phagocytosis of antigens by immune cells?

    <p>Crosslinking with antibodies bound to antigens</p> Signup and view all the answers

    Which statement is true regarding IgD?

    <p>Promotes basophil and mast cell release of AMPs</p> Signup and view all the answers

    What is the role of IgG in the immune system?

    <p>Is particularly good at complement fixation</p> Signup and view all the answers

    What is the function of IgA in the body?

    <p>Is found in secretions and is effective at neutralizing toxins and pathogens</p> Signup and view all the answers

    What is the primary role of IgE in the immune system?

    <p>Is best known for roles in allergy, asthma, and parasitic worm infection</p> Signup and view all the answers

    Which pathway of the complement system relies on C1q binding to IgG and IgA antibodies?

    <p>Classical pathway</p> Signup and view all the answers

    'Antibodies must be cross-linked in order for them to trigger an Fc receptor-mediated signal.' - Is this statement true or false?

    <p>True</p> Signup and view all the answers

    Which antibody class is present at higher levels in secretions of the upper respiratory tract but is a tiny component of blood?

    <p>IgA</p> Signup and view all the answers

    Which antibody class is the first antibody produced in a primary immune response and exhibits pentavalent opsonization?

    <p>IgM</p> Signup and view all the answers

    Which mechanism results in the formation of the Membrane Attack Complex (MAC) to destroy target cells?

    <p>Complement Activation</p> Signup and view all the answers

    Which antibody class is particularly effective at complement fixation, aiding in the destruction of pathogens?

    <p>IgA</p> Signup and view all the answers

    Which antibody class plays a prominent role in allergic responses, asthma, and parasitic worm infections?

    <p>IgE</p> Signup and view all the answers

    How does antibody-dependent cell-mediated cytotoxicity (ADCC) primarily lead to target cell death?

    <p>Induction of apoptosis by activation of NK cells</p> Signup and view all the answers

    What is the main difference between IgM and IgG antibodies in initiating the complement cascade?

    <p>Number of antigen binding sites</p> Signup and view all the answers

    Which cell type expresses receptors that can recognize the Fc portion of IgE and IgG antibodies, leading to specific immune responses?

    <p>Granulocytes</p> Signup and view all the answers

    What is the primary function of Fc receptors on macrophages in response to antibody opsonization?

    <p>Promoting engulfment of antigens by phagocytosis</p> Signup and view all the answers

    What is the main effector function of mast cells when activated by TH2 cytokines in response to pathogens?

    <p>Release of histamine and other molecules from granules</p> Signup and view all the answers

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