Lecture 8: B Cells
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Questions and Answers

What is the main function of Fc receptors in the immune system?

  • Cytokine production
  • Phagocytosis enhancement (correct)
  • Memory cell activation
  • Antigen presentation

Which subclass of antibodies is NOT mentioned as being effective at complement fixation?

  • IgG2
  • IgA (correct)
  • IgG1
  • IgG3

What is the primary role of NK cells in antibody-dependent cell-mediated cytotoxicity (ADCC)?

  • Antigen presentation
  • Cell killing (correct)
  • Histamine release
  • Cytokine secretion

Which cells are primarily involved in antibody-dependent degranulation from granulocytes?

<p>Eosinophils and basophils (A)</p> Signup and view all the answers

Which type of antibodies are most important for neutralization to protect against infections?

<p>IgG and IgM (A)</p> Signup and view all the answers

What is one of the main roles of IgA antibodies in the body?

<p>Neutralization in mucosal tissues (D)</p> Signup and view all the answers

Which antibody class is widely distributed in the body, including to the developing fetus?

<p>IgG (B)</p> Signup and view all the answers

What is the primary function of Fc receptors on granulocytes in response to pathogens?

<p>Degranulation (A)</p> Signup and view all the answers

What is the main mechanism by which Fc receptors enhance phagocytosis of antigens by immune cells?

<p>Crosslinking with antibodies bound to antigens (C)</p> Signup and view all the answers

Which statement is true regarding IgD?

<p>Promotes basophil and mast cell release of AMPs (D)</p> Signup and view all the answers

What is the role of IgG in the immune system?

<p>Is particularly good at complement fixation (C)</p> Signup and view all the answers

What is the function of IgA in the body?

<p>Is found in secretions and is effective at neutralizing toxins and pathogens (D)</p> Signup and view all the answers

What is the primary role of IgE in the immune system?

<p>Is best known for roles in allergy, asthma, and parasitic worm infection (A)</p> Signup and view all the answers

Which pathway of the complement system relies on C1q binding to IgG and IgA antibodies?

<p>Classical pathway (B)</p> Signup and view all the answers

'Antibodies must be cross-linked in order for them to trigger an Fc receptor-mediated signal.' - Is this statement true or false?

<p>True (C)</p> Signup and view all the answers

Which antibody class is present at higher levels in secretions of the upper respiratory tract but is a tiny component of blood?

<p>IgA (A)</p> Signup and view all the answers

Which antibody class is the first antibody produced in a primary immune response and exhibits pentavalent opsonization?

<p>IgM (D)</p> Signup and view all the answers

Which mechanism results in the formation of the Membrane Attack Complex (MAC) to destroy target cells?

<p>Complement Activation (D)</p> Signup and view all the answers

Which antibody class is particularly effective at complement fixation, aiding in the destruction of pathogens?

<p>IgA (C)</p> Signup and view all the answers

Which antibody class plays a prominent role in allergic responses, asthma, and parasitic worm infections?

<p>IgE (B)</p> Signup and view all the answers

How does antibody-dependent cell-mediated cytotoxicity (ADCC) primarily lead to target cell death?

<p>Induction of apoptosis by activation of NK cells (B)</p> Signup and view all the answers

What is the main difference between IgM and IgG antibodies in initiating the complement cascade?

<p>Number of antigen binding sites (A)</p> Signup and view all the answers

Which cell type expresses receptors that can recognize the Fc portion of IgE and IgG antibodies, leading to specific immune responses?

<p>Granulocytes (B)</p> Signup and view all the answers

What is the primary function of Fc receptors on macrophages in response to antibody opsonization?

<p>Promoting engulfment of antigens by phagocytosis (D)</p> Signup and view all the answers

What is the main effector function of mast cells when activated by TH2 cytokines in response to pathogens?

<p>Release of histamine and other molecules from granules (B)</p> Signup and view all the answers

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