Podcast
Questions and Answers
What is the purpose of secondary diversification in the germinal center?
What is the purpose of secondary diversification in the germinal center?
- To change the antigen specificity of B cells
- To increase the affinity of B cells for antigens (correct)
- To lower the specificity of antibodies produced
- To prevent B cells from recognizing antigens
Which region of the germinal center is primarily responsible for somatic hypermutation?
Which region of the germinal center is primarily responsible for somatic hypermutation?
- Light zone
- Dark zone (correct)
- T follicular helper cells
- Follicular dendritic cells
What does class switching in B cells involve?
What does class switching in B cells involve?
- Initiating V(D)J recombination in the B cell
- Replacing one heavy chain constant region with another isotype (correct)
- Altering the variable region of the antibody
- Changing the antigen binding specificity of the B cell
Where do B cells migrate after undergoing somatic hypermutation?
Where do B cells migrate after undergoing somatic hypermutation?
What happens to B cells with low affinity for antigens in the light zone of the germinal center?
What happens to B cells with low affinity for antigens in the light zone of the germinal center?
Which cells provide conditions for B cell differentiation and memory cell production in the germinal center?
Which cells provide conditions for B cell differentiation and memory cell production in the germinal center?
How do B cells in the germinal center receive signals for class switching?
How do B cells in the germinal center receive signals for class switching?
'Affinity maturation' in the germinal center refers to the process of selecting mutated B cells based on their:
'Affinity maturation' in the germinal center refers to the process of selecting mutated B cells based on their:
'Selecting for the survival of mutated B cells that have a high affinity for the antigen' primarily occurs during:
'Selecting for the survival of mutated B cells that have a high affinity for the antigen' primarily occurs during:
What is the process used to ensure that each B cell synthesizes only one heavy and one light chain?
What is the process used to ensure that each B cell synthesizes only one heavy and one light chain?
What is the function of TdT in B cells?
What is the function of TdT in B cells?
Where are T FH cells predominantly found within the germinal center?
Where are T FH cells predominantly found within the germinal center?
Which type of dendritic cell retains antigens in the light zone of the germinal center?
Which type of dendritic cell retains antigens in the light zone of the germinal center?
Which enzyme recognizes gene segments during somatic hypermutation?
Which enzyme recognizes gene segments during somatic hypermutation?
What is the primary function of plasmablasts?
What is the primary function of plasmablasts?
What is the primary feature that distinguishes the dark zone from the light zone in the germinal center?
What is the primary feature that distinguishes the dark zone from the light zone in the germinal center?
What is the main function of conventional dendritic cells in the immune response?
What is the main function of conventional dendritic cells in the immune response?
What is the role of SCS macrophages in the germinal center?
What is the role of SCS macrophages in the germinal center?
What is the primary outcome of somatic hypermutation in B cells?
What is the primary outcome of somatic hypermutation in B cells?
What is the role of plasma cells in the Germinal Center?
What is the role of plasma cells in the Germinal Center?
What is the main function of memory B cells?
What is the main function of memory B cells?
Which protein is responsible for deaminating cytidine residues in ssDNA during somatic hypermutation?
Which protein is responsible for deaminating cytidine residues in ssDNA during somatic hypermutation?
What is the outcome of class switch recombination within the germinal center?
What is the outcome of class switch recombination within the germinal center?
Where does somatic hypermutation mainly occur in the immunoglobulin variable regions?
Where does somatic hypermutation mainly occur in the immunoglobulin variable regions?
Which cytokine signal determines the isotype produced during class switch recombination?
Which cytokine signal determines the isotype produced during class switch recombination?
What is the main outcome of affinity maturation in B cells?
What is the main outcome of affinity maturation in B cells?
What is the primary difference between primary and memory responses to antigens?
What is the primary difference between primary and memory responses to antigens?
How can you best monitor immunological memory for T cells?
How can you best monitor immunological memory for T cells?
What determines if immunological memory is long-lived or short-lived?
What determines if immunological memory is long-lived or short-lived?
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