7 Questions
Which proteins are targeted for proteolytic digestion by the ubiquitin-proteasome pathway?
All of the above
What happens to unfolded proteins in the cell?
They are degraded into peptides by the proteasomes
Which cells become very efficient at cleaving cytosolic and nuclear proteins into peptides?
Cells exposed to inflammatory cytokines
Which molecule is responsible for transporting proteasome-generated peptides into the ER?
TAP molecules
What is the function of tapasin in the peptide loading process?
It links MHC molecules to TAP molecules
Why are empty class I MHC molecules eventually degraded in the ER?
They are unstable without bound peptides
What happens when a class I MHC molecule binds tightly to a peptide generated from proteasomal digestion?
The peptide-MHC complex becomes stable and is delivered to the cell surface
Quiz: Understanding Peptide Binding to Class I MHC Molecules Test your knowledge on the peptides that bind to class I MHC molecules, which are derived from cytosolic proteins through the ubiquitin-proteasome pathway. This quiz explores how antigenic proteins are produced in the cytoplasm, including viruses living inside infected cells and phagocytosed microbes. Discover more about mutated or altered host genes that contribute to antigen production.
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