Podcast
Questions and Answers
What is the phenomenon called when an individual B cell can express an Ig heavy chain protein encoded by only one of the two inherited alleles?
What is the phenomenon called when an individual B cell can express an Ig heavy chain protein encoded by only one of the two inherited alleles?
What is the role of a μ protein produced from the recombined heavy chain locus in forming a pre-BCR?
What is the role of a μ protein produced from the recombined heavy chain locus in forming a pre-BCR?
What happens if the first rearrangement of the Ig heavy chain locus is non-productive?
What happens if the first rearrangement of the Ig heavy chain locus is non-productive?
At what stage does each developing B cell initially rearrange a κ light chain gene?
At what stage does each developing B cell initially rearrange a κ light chain gene?
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Which mechanism ensures that every B cell will express a single receptor?
Which mechanism ensures that every B cell will express a single receptor?
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What is the role of Activation-induced cytidine deaminase (AID) in B cells?
What is the role of Activation-induced cytidine deaminase (AID) in B cells?
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Which process leads to increased antibody affinity during a T-dependent humoral response?
Which process leads to increased antibody affinity during a T-dependent humoral response?
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What happens to the Ig heavy chain DNA in B cells during the class switching process?
What happens to the Ig heavy chain DNA in B cells during the class switching process?
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What type of mutations are generated within the variable region of expressed immunoglobulin genes during somatic hypermutation?
What type of mutations are generated within the variable region of expressed immunoglobulin genes during somatic hypermutation?
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In T-dependent responses, what progeny of activated B cells undergo heavy chain isotype switching?
In T-dependent responses, what progeny of activated B cells undergo heavy chain isotype switching?
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Which process results in the production of antibodies with heavy chains of different classes like γ, α, and ε?
Which process results in the production of antibodies with heavy chains of different classes like γ, α, and ε?
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How many separate loci encode all of the Ig heavy chains, the Ig κ light chain, and the Ig λ light chain in humans?
How many separate loci encode all of the Ig heavy chains, the Ig κ light chain, and the Ig λ light chain in humans?
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Which of the following is not a true statement about the clonal selection hypothesis?
Which of the following is not a true statement about the clonal selection hypothesis?
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What is the function of the hypervariable (complementarity-determining) regions in Ig protein domains?
What is the function of the hypervariable (complementarity-determining) regions in Ig protein domains?
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Which of the following statements about the variable number of C genes at Ig loci is true?
Which of the following statements about the variable number of C genes at Ig loci is true?
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Which of the following statements about the germline organization of human Ig loci is true?
Which of the following statements about the germline organization of human Ig loci is true?
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