Podcast
Questions and Answers
What is the configuration of the TCR genes in the earliest cell entering the thymus?
What is the configuration of the TCR genes in the earliest cell entering the thymus?
- Unrearranged
- Partially rearranged
- Completely rearranged
- Rearranged (correct)
What is the order of gene rearrangement if the γ chain genes rearrange successfully?
What is the order of gene rearrangement if the γ chain genes rearrange successfully?
- α gene rearrangement then δ chain genes
- β gene rearrangement then δ chain genes
- δ chain genes then α gene rearrangement
- δ chain genes then β gene rearrangement (correct)
What is the role of recombination activation genes (RAGs) in T cells?
What is the role of recombination activation genes (RAGs) in T cells?
- To generate TCR diversity
- To inhibit the recombinase gene
- To activate the recombinase gene (correct)
- To regulate the allelic exclusion
What is the approximate number of different TCR structures that can be generated from αβ and γδ TCRs?
What is the approximate number of different TCR structures that can be generated from αβ and γδ TCRs?
What is the process called when no further gene rearrangements occur after successful gene rearrangements?
What is the process called when no further gene rearrangements occur after successful gene rearrangements?
What happens if all the gene rearrangements are unsuccessful?
What happens if all the gene rearrangements are unsuccessful?
What is the function of RAG-1 and RAG-2 genes in the process of recombination?
What is the function of RAG-1 and RAG-2 genes in the process of recombination?
What is the difference between immuneoglobulin genes and genes encoding TCR?
What is the difference between immuneoglobulin genes and genes encoding TCR?
Where do T lymphocytes develop?
Where do T lymphocytes develop?
What is the function of positive selection in the thymus?
What is the function of positive selection in the thymus?
What is the outcome of TCRs binding too strongly to p-MHC in the thymus?
What is the outcome of TCRs binding too strongly to p-MHC in the thymus?
What is the outcome of a defect in RAG-1 or RAG-2 genes?
What is the outcome of a defect in RAG-1 or RAG-2 genes?
What is the name of the cells that do not express either the CD4 or CD8 co-receptor?
What is the name of the cells that do not express either the CD4 or CD8 co-receptor?
At what stage do the cells decide to become δγ or αβ T cells?
At what stage do the cells decide to become δγ or αβ T cells?
What percentage of thymocytes never become fully functional and die in the thymus?
What percentage of thymocytes never become fully functional and die in the thymus?
What is the result of positive selection?
What is the result of positive selection?
What is the function of negative selection?
What is the function of negative selection?
What type of molecule is associated with the TCR β chain on the surface of pre-T cells?
What type of molecule is associated with the TCR β chain on the surface of pre-T cells?
What type of T-cells are MHC II restricted and recognize specific foreign peptides only when presented in association with specific MHC II molecules?
What type of T-cells are MHC II restricted and recognize specific foreign peptides only when presented in association with specific MHC II molecules?
Which type of T-cells produces cytokines of CMI and inflammation?
Which type of T-cells produces cytokines of CMI and inflammation?
What is the primary function of CD4 T-cells when recognizing antigen on the surface of APC?
What is the primary function of CD4 T-cells when recognizing antigen on the surface of APC?
What is the term for the process by which T-cells that are unable to bind to MHC molecules are eliminated?
What is the term for the process by which T-cells that are unable to bind to MHC molecules are eliminated?
What is the primary function of CD8 T-cells?
What is the primary function of CD8 T-cells?
What is the term for immature T-cells that express both CD4 and CD8?
What is the term for immature T-cells that express both CD4 and CD8?
What is the result of pre-TCR signaling in the development of cells expressing α and β as their TCR?
What is the result of pre-TCR signaling in the development of cells expressing α and β as their TCR?
What is the main function of positive selection in thymic selection?
What is the main function of positive selection in thymic selection?
What is the composition of the pre-T cell receptor (pre-TCR)?
What is the composition of the pre-T cell receptor (pre-TCR)?
What is the outcome of double positive cells that do not interact with MHC class I and II molecules?
What is the outcome of double positive cells that do not interact with MHC class I and II molecules?
What is the percentage of thymocytes that are double positive cells?
What is the percentage of thymocytes that are double positive cells?
What is the role of thymic non-lymphoid cells in thymic selection?
What is the role of thymic non-lymphoid cells in thymic selection?
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