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Questions and Answers
Which adrenergic receptor type is primarily associated with inhibitory functions in the gut?
Which adrenergic receptor type is primarily associated with inhibitory functions in the gut?
What is the primary neurotransmitter released by the terminal ends of post-ganglionic fibers in the sympathetic nervous system?
What is the primary neurotransmitter released by the terminal ends of post-ganglionic fibers in the sympathetic nervous system?
Which of the following conditions would likely cause flaccid paralysis due to a blockade in acetylcholine transmission?
Which of the following conditions would likely cause flaccid paralysis due to a blockade in acetylcholine transmission?
How does smooth muscle differ from skeletal muscle in terms of its overall structure?
How does smooth muscle differ from skeletal muscle in terms of its overall structure?
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Which component of muscle physiology is responsible for detecting changes in muscle length?
Which component of muscle physiology is responsible for detecting changes in muscle length?
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Which type of muscle contraction is characterized by sustained tension despite relaxation when stretched?
Which type of muscle contraction is characterized by sustained tension despite relaxation when stretched?
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Which type of muscle fibers are primarily responsible for the contraction of skeletal muscle?
Which type of muscle fibers are primarily responsible for the contraction of skeletal muscle?
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What mechanism allows muscles to contract as a unit in single-unit smooth muscle?
What mechanism allows muscles to contract as a unit in single-unit smooth muscle?
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Which structure is primarily responsible for holding thick filaments together in muscle fibers?
Which structure is primarily responsible for holding thick filaments together in muscle fibers?
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Which spinal regions give rise to parasympathetic preganglionic fibers?
Which spinal regions give rise to parasympathetic preganglionic fibers?
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What is the role of Sertoli cells in spermatogenesis?
What is the role of Sertoli cells in spermatogenesis?
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What primarily regulates the secretion of follicle-stimulating hormone (FSH) in males?
What primarily regulates the secretion of follicle-stimulating hormone (FSH) in males?
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What event marks the transition from the follicular phase to the luteal phase in the ovarian cycle?
What event marks the transition from the follicular phase to the luteal phase in the ovarian cycle?
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During the menstrual cycle, what happens in the proliferative phase?
During the menstrual cycle, what happens in the proliferative phase?
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What is the role of kisspeptin in the male reproductive system?
What is the role of kisspeptin in the male reproductive system?
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Which structure in the brain is responsible for homeostatic control and emotional regulation?
Which structure in the brain is responsible for homeostatic control and emotional regulation?
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Which cells produce hormones in the corpus luteum after ovulation?
Which cells produce hormones in the corpus luteum after ovulation?
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What is the consequence of a high enough estrogen level during the ovarian cycle?
What is the consequence of a high enough estrogen level during the ovarian cycle?
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Which part of the nervous system includes the brain and spinal cord?
Which part of the nervous system includes the brain and spinal cord?
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What is the primary function of astrocytes in the central nervous system?
What is the primary function of astrocytes in the central nervous system?
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In which phase does fertilization of the egg typically occur?
In which phase does fertilization of the egg typically occur?
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What is the result of capacitation in sperm when preparing for fertilization?
What is the result of capacitation in sperm when preparing for fertilization?
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What hormonal feedback mechanism occurs after testosterone production in males?
What hormonal feedback mechanism occurs after testosterone production in males?
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What is the role of the hippocampus in memory retention?
What is the role of the hippocampus in memory retention?
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What characterizes long-term potentiation in neurons?
What characterizes long-term potentiation in neurons?
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Which of the following types of waves is associated with deep sleep?
Which of the following types of waves is associated with deep sleep?
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What type of receptor is primarily involved in detecting pain sensations?
What type of receptor is primarily involved in detecting pain sensations?
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How is peripheral vision processed in the brain?
How is peripheral vision processed in the brain?
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What distinguishes fast pain from slow pain?
What distinguishes fast pain from slow pain?
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Which beneficial effect do endogenous opioids produce?
Which beneficial effect do endogenous opioids produce?
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Which structure in the eye is primarily responsible for light refraction?
Which structure in the eye is primarily responsible for light refraction?
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What type of muscle contraction occurs when a muscle lengthens under tension?
What type of muscle contraction occurs when a muscle lengthens under tension?
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What is the primary function of sarcoplasmic reticulum in muscle fibers?
What is the primary function of sarcoplasmic reticulum in muscle fibers?
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What distinguishes the sympathetic nervous system from the parasympathetic nervous system?
What distinguishes the sympathetic nervous system from the parasympathetic nervous system?
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What is the expected effect of ciliary muscle contraction on the lens of the eye?
What is the expected effect of ciliary muscle contraction on the lens of the eye?
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Which neurotransmitter is primarily associated with the sympathetic nervous system?
Which neurotransmitter is primarily associated with the sympathetic nervous system?
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Which factor does NOT affect the strength of muscle contraction?
Which factor does NOT affect the strength of muscle contraction?
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Which cellular function involves the movement of substances within the cell’s cytoplasm?
Which cellular function involves the movement of substances within the cell’s cytoplasm?
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What is the main role of ribosomal RNA (rRNA) in cellular function?
What is the main role of ribosomal RNA (rRNA) in cellular function?
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Which type of transport mechanism requires direct use of ATP?
Which type of transport mechanism requires direct use of ATP?
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Which type of feedback system usually results in an escalation of a physiological response until a certain point is reached?
Which type of feedback system usually results in an escalation of a physiological response until a certain point is reached?
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What is one of the primary functions of membrane-bound proteins?
What is one of the primary functions of membrane-bound proteins?
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What phenomenon describes a neuron's inability to generate another action potential for a brief period after one has occurred?
What phenomenon describes a neuron's inability to generate another action potential for a brief period after one has occurred?
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Which hormone is primarily involved in increasing blood glucose levels during fasting?
Which hormone is primarily involved in increasing blood glucose levels during fasting?
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What is the main characteristic of graded potentials?
What is the main characteristic of graded potentials?
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Which type of heart rhythms can be influenced by neurotransmitters affecting receptor sensitivity?
Which type of heart rhythms can be influenced by neurotransmitters affecting receptor sensitivity?
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Which nutrient is the brain primarily dependent on for energy?
Which nutrient is the brain primarily dependent on for energy?
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What describes the process of signal transduction for lipid-soluble hormones?
What describes the process of signal transduction for lipid-soluble hormones?
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Which fluid represents the major component of extracellular fluid (ECF)?
Which fluid represents the major component of extracellular fluid (ECF)?
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Which type of extracellular chemical messenger acts locally on neighboring cells?
Which type of extracellular chemical messenger acts locally on neighboring cells?
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Which nervous system response is considered a 'wireless' mode of communication?
Which nervous system response is considered a 'wireless' mode of communication?
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What phenomenon occurs when too much parathyroid hormone (PTH) is secreted?
What phenomenon occurs when too much parathyroid hormone (PTH) is secreted?
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What triggers the secretion of LH and FSH during puberty?
What triggers the secretion of LH and FSH during puberty?
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What is the primary function of the corpus luteum?
What is the primary function of the corpus luteum?
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Which phase of the menstrual cycle is characterized by endometrial growth?
Which phase of the menstrual cycle is characterized by endometrial growth?
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During spermatogenesis, what is the function of Sertoli cells?
During spermatogenesis, what is the function of Sertoli cells?
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What triggers ovulation in the ovarian cycle?
What triggers ovulation in the ovarian cycle?
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How do androgens contribute to the female reproductive cycle?
How do androgens contribute to the female reproductive cycle?
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What is the main role of the blood-brain barrier?
What is the main role of the blood-brain barrier?
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Which hormone is secreted by the placenta during pregnancy?
Which hormone is secreted by the placenta during pregnancy?
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What type of feedback mechanism does estrogen demonstrate to control FSH and LH levels before ovulation?
What type of feedback mechanism does estrogen demonstrate to control FSH and LH levels before ovulation?
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What is the role of prolactin during late pregnancy?
What is the role of prolactin during late pregnancy?
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What process describes the transformation of primary oocytes to secondary oocytes.
What process describes the transformation of primary oocytes to secondary oocytes.
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Which component of the central nervous system is primarily responsible for coordinating voluntary movement?
Which component of the central nervous system is primarily responsible for coordinating voluntary movement?
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What is the primary role of neuroglia in the central nervous system?
What is the primary role of neuroglia in the central nervous system?
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Which part of the brain is crucial for processing visual information?
Which part of the brain is crucial for processing visual information?
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Which of the following is NOT a function of cell membranes?
Which of the following is NOT a function of cell membranes?
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What is the primary role of smooth endoplasmic reticulum (SER)?
What is the primary role of smooth endoplasmic reticulum (SER)?
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Which statement accurately describes the resting membrane potential?
Which statement accurately describes the resting membrane potential?
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What triggers an action potential in a neuron?
What triggers an action potential in a neuron?
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What is the primary mechanism for transmitting chemical signals across a synapse?
What is the primary mechanism for transmitting chemical signals across a synapse?
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In terms of hormone classification, which characteristic differs between hydrophilic and lipophilic hormones?
In terms of hormone classification, which characteristic differs between hydrophilic and lipophilic hormones?
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How do tropic hormones function in the endocrine system?
How do tropic hormones function in the endocrine system?
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What is a characteristic effect of parathormone (PTH) on calcium levels?
What is a characteristic effect of parathormone (PTH) on calcium levels?
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What role does the cerebellum play in memory?
What role does the cerebellum play in memory?
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How do tonic receptors respond to sustained stimuli?
How do tonic receptors respond to sustained stimuli?
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Which of the following pathways is specifically associated with lipid-soluble hormones?
Which of the following pathways is specifically associated with lipid-soluble hormones?
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What physiological change is associated with hypopolarization of a neuron?
What physiological change is associated with hypopolarization of a neuron?
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Which type of muscle contraction involves a muscle shortening while lifting a constant load?
Which type of muscle contraction involves a muscle shortening while lifting a constant load?
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What is a primary function of the adrenal cortex?
What is a primary function of the adrenal cortex?
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What is the primary function of the medulla in the brainstem?
What is the primary function of the medulla in the brainstem?
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Which neurotransmitter is primarily associated with pain transmission in the nervous system?
Which neurotransmitter is primarily associated with pain transmission in the nervous system?
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Which type of transport mechanism primarily uses sodium gradients for glucose uptake?
Which type of transport mechanism primarily uses sodium gradients for glucose uptake?
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What is the significance of the sliding filament mechanism in muscle contraction?
What is the significance of the sliding filament mechanism in muscle contraction?
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What is the physiological importance of the Nernst Equation?
What is the physiological importance of the Nernst Equation?
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Which type of receptor is primarily involved in the sensation of light touch?
Which type of receptor is primarily involved in the sensation of light touch?
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Which of the following accurately describes a mechanistic aspect of graded potentials?
Which of the following accurately describes a mechanistic aspect of graded potentials?
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Which layer of the eye contains the photoreceptors responsible for vision?
Which layer of the eye contains the photoreceptors responsible for vision?
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How does the sympathetic nervous system primarily affect the body?
How does the sympathetic nervous system primarily affect the body?
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What is the main factor that determines the acuity of a sensory stimulus?
What is the main factor that determines the acuity of a sensory stimulus?
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Which muscle fibers are characterized as fatigue-resistant and have a low ATPase activity?
Which muscle fibers are characterized as fatigue-resistant and have a low ATPase activity?
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What is the role of the vestibular apparatus in the inner ear?
What is the role of the vestibular apparatus in the inner ear?
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What is the primary function of the Golgi tendon organs?
What is the primary function of the Golgi tendon organs?
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What common condition is characterized by a loss of muscle mass due to disuse?
What common condition is characterized by a loss of muscle mass due to disuse?
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Which type of pain is associated with unmyelinated C-fibers?
Which type of pain is associated with unmyelinated C-fibers?
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Study Notes
Autonomic Nervous System
- Muscarinic Receptors: Found between preganglionic and effector tissue
-
Adrenergic Receptors (bind with NE):
- α1: excitatory; arteriolar smooth muscle (NE > E)
- α2: inhibitory; always in gut (NE > E)
- β1: excitatory; always in heart (NE = E)
- β2: inhibitory; arteriolar smooth muscle, heart, skeletal (E)
- Varicosities: Terminal end of postganglionic neuron; releases neurotransmitter across a large area
- Dual Innervation: Parasympathetic and sympathetic systems typically innervate organs. Exceptions are liver, thermoregulatory sweat glands, adrenal medulla, and blood vessels. Salivary glands are an exception, being stimulated by both.
-
Preganglionic Fiber Origins:
- Parasympathetic: cranial and sacral regions of spinal cord
- Sympathetic: thoracolumbar region of spinal cord
Somatic Nervous System
-
Skeletal Muscle Innervation:
- Excitatory pathway using nicotinic receptors
- Acetylcholine (ACh) causes an end-plate potential, opening sodium (Na+) and potassium (K+) channels (similar to EPSP)
-
Conditions Affecting Skeletal Muscle Innervation:
- Black widow toxin: Increased ACh release (leads to spastic then flaccid paralysis)
- Botulism: Blocks ACh release (flaccid paralysis)
- Curare: Blocks ACh receptors (flaccid paralysis)
- Succinylcholine: Similar to ACh (leads to spastic then flaccid paralysis)
- Organophosphates: Inhibit acetylcholinesterase (AChE) (leads to spastic then flaccid paralysis)
- Spastic-to-flaccid Paralysis Cause: Depolarization blockade (Na+ inactivation gate resetting)
Muscle Physiology
-
Muscle Categories:
- Striated (skeletal/cardiac): dark bands
- Nucleated (skeletal): multiple nuclei
- Voluntary (skeletal): innervated by somatic nervous system
- Electrical Isolation of Muscle Fibers: Allows for precise control
-
Myofibril Components:
- Titin: Largest protein; throughout the fiber, acts like a rubber band
- A bands: Stacked thick filaments with peripheral thin filaments
- H zone: Middle of A band; thin filaments absent
- M line: Center of H zone; holds thick filaments together
- I bands: Thin filaments not in A band
- Z line/disk: Center of I band; between defines sarcomere (contracts)
-
Skeletal Muscle Control Systems:
- Primary motor cortex/corticospinal system: Pyramidal cells; fine control
- Brain stem/multi neuronal motor system: extrapyramidal; brain influences posture and large muscles
- Muscle Tone: Ongoing, involuntary, low-level tension for stability
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Muscle Receptors:
-
Muscle Spindles: Detect changes in muscle length/stretch; specialized intrafusal and extrafusal fibers. Involved in the stretch reflex and alpha-gamma coactivation.
- Intrafusal fibers (gamma motor) are inside extrafusal fibers (alpha motor)
- Gamma motor neurons innervate both sides of the intrafusal fibers
- Alpha-gamma coactivation: both types of neurons stimulate during contraction. Necessary for intrafusal fiber detection of both rate and change of length.
- Stretch reflex (monosynaptic): Localized negative-feedback; prevents overstretching.
- Golgi tendon organs: In tendons; detect tension, important for proprioception
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Muscle Spindles: Detect changes in muscle length/stretch; specialized intrafusal and extrafusal fibers. Involved in the stretch reflex and alpha-gamma coactivation.
Smooth Muscle
-
Smooth Muscle Structure: Small, unstriated; structure varies by function
- Thick myosin (longer than in skeletal), thin actin (no troponin)
- Intermediate filaments (framework); no myofibrils or sarcomere pattern (no Z line)
- Dense bodies: More actin; act as Z discs, held via intermediates
- Arranged for squeezing, diagonals (cross-over = dense body)
- Activation: Ca2+ (mostly extracellular) dependent myosin phosphorylation
- Contraction Types: Phasic (burst contractions) and tonic (continuous contraction)
- Stress Relaxation: Develops tension despite relaxing when stretched (like a rubber band)
- Speed/Efficiency: Slow but efficient contractions; suited for long-term sustained contractions
-
Types:
- Single-unit/visceral: Found in viscera (hollow organs); myogenic (self-excitable, either tonic or phasic); forms functional syncytium (contracts as a unit)
- Multiunit: Skeletal/smooth mix; neurogenic (stimulated by nerves, phasic); found in large blood vessels, small airways, eye muscles, goosebump muscles
- Pacemaker/Slow-wave: Spontaneous depolarization from ion flux; alternating polarizations
Cardiac Muscle
- Location: Found only in the heart
- Structure: Striated, length-tension relationship; pacemaker potentials/cells
- Intercalated Discs: Gap junctions, joined in a branching network
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Description
Test your knowledge on the autonomic and somatic nervous systems, including the functions and types of receptors such as muscarinic and adrenergic. Additionally, explore the dual innervation mechanisms and the origins of preganglionic fibers. This quiz is essential for understanding the intricacies of human nervous control.