20 Questions
Which cells can co-activate B cells in response to non-self antigens?
T4 cells
In the immune system with perfect immune tolerance, what should not be able to activate T cells or B cells?
Self-antigens
What is the consequence of T8 cells recognizing self-antigens under MHCI antigen presentation?
Destruction of cells holding self antigens
Which cells are capable of synthesizing antibodies in response to non-self antigens?
B lymphocytes
What can lead to an autoimmune disease?
Recognition of self-antigens as non-self antigens
Which of the following is NOT a potential consequence of tolerance breakdown?
Auto-antibody formation
What do auto-antibodies and auto-reactive immune cells characterize?
Autoimmunity
What is the role of the MHC locus in autoimmunity?
Susceptibility to autoimmunity
Which type of immune tolerance is essential to prevent autoimmunity?
Ignorance (hidden and sequestrated antigens)
What is the consequence of autoimmune responses in the body?
Formation of auto-antibodies
Which type of cells recognize antigens 'carried' by MHC I?
T8 cells
What is the consequence of T4 cells recognizing non self-antigens under MHCII presentation?
Costimulation of an immune response against the cells with non self-antigens
What characterizes autoimmune T cells or B cells in the immune system with a defect in immune tolerance?
Activation by non self-antigens
What is the role of autoantibodies and auto-reactive immune cells in the context of autoimmune diseases?
Targeting of self-antigens
Which type of immune response can be co-activated by B cells in response to non self-antigens?
Immune response against non self-antigens
What is the central purpose of the lecture on autoimmunity?
To introduce the concept of autoimmune responses and discuss the breakdown of immune tolerance
What is the consequence of tolerance breakdown?
Selection (e.g., Thymus)
Which immune tolerance is essential to prevent autoimmunity?
Central and Peripheral immune tolerance
What is the role of the MHC locus in autoimmunity?
It plays a role in the susceptibility of autoimmunity
What is the key factor characterizing autoimmunity?
Presence of auto-antibodies and auto-reactive immune cells
Learn about the concept of autoimmune responses and the breakdown of immune tolerance, understand the consequences of autoimmunity, and appreciate the role of the MHC locus in susceptibility to autoimmunity. This lecture also covers examples of autoimmune diseases.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
