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15 Questions

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Guest Lecture: Multiple Sclerosis

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Questions and Answers

What is the main cause of multiple sclerosis?

Inflammation leading to demyelination (correct)

Excessive production of myelin

Immune system attacking muscle cells

Genetic mutations in neurons

Which type of immune cells cross the blood-brain barrier in multiple sclerosis?

Monocytes

Eosinophils

Neutrophils

Lymphocytes (correct)

What is the main function of Treg cells in multiple sclerosis?

Induce inflammation

Promote autoimmune response

Produce myelin

Regulate autoreactive T cells (correct)

Which type of multiple sclerosis is characterized by steady disability progression without remissions or relapses?

Primary progressive MS Signup and view all the answers

What is one of the symptoms commonly associated with multiple sclerosis?

Impaired gait Signup and view all the answers

What do lesions observed by MRI indicate in multiple sclerosis?

Destruction of myelin sheath Signup and view all the answers

Which therapy for Multiple Sclerosis (MS) is known to reduce relapses by approximately 30%?

Subcutaneous daclizumab Signup and view all the answers

What is a potential mechanism of corticosteroids used in treating MS?

Inhibiting T cell differentiation Signup and view all the answers

What is the method used to collect cerebral fluid to determine inflammation in the central nervous system (CNS)?

Spinal Tap or Lumbar puncture Signup and view all the answers

Which of the following is NOT a potential mechanism of action for Interferon-beta therapy in MS treatment?

Inducing T cell proliferation Signup and view all the answers

What is the main function of corticosteroid therapy in Multiple Sclerosis?

Induce apoptosis in lymphocytes Signup and view all the answers

Which therapy became the first oral drug to be approved for the treatment of Relapsing-Remitting Multiple Sclerosis (RRMS)?

Oral dimethyl fumarate Signup and view all the answers

What is one potential mechanism of action of dimethyl fumarate therapy in MS?

Reduces antigen-presenting capacity of APCs Signup and view all the answers

Which type of MS shows a decrease in relapses by 50% with dimethyl fumarate therapy?

Relapsing-Remitting MS (RRMS) Signup and view all the answers

Which therapy was more recently approved for MS treatment in 2013?

Oral cladribine Signup and view all the answers