Guest Lecture: Multiple Sclerosis
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Questions and Answers

What is the main cause of multiple sclerosis?

  • Inflammation leading to demyelination (correct)
  • Excessive production of myelin
  • Immune system attacking muscle cells
  • Genetic mutations in neurons

Which type of immune cells cross the blood-brain barrier in multiple sclerosis?

  • Monocytes
  • Eosinophils
  • Neutrophils
  • Lymphocytes (correct)

What is the main function of Treg cells in multiple sclerosis?

  • Induce inflammation
  • Promote autoimmune response
  • Produce myelin
  • Regulate autoreactive T cells (correct)

Which type of multiple sclerosis is characterized by steady disability progression without remissions or relapses?

<p>Primary progressive MS (A)</p> Signup and view all the answers

What is one of the symptoms commonly associated with multiple sclerosis?

<p>Impaired gait (C)</p> Signup and view all the answers

What do lesions observed by MRI indicate in multiple sclerosis?

<p>Destruction of myelin sheath (C)</p> Signup and view all the answers

Which therapy for Multiple Sclerosis (MS) is known to reduce relapses by approximately 30%?

<p>Subcutaneous daclizumab (D)</p> Signup and view all the answers

What is a potential mechanism of corticosteroids used in treating MS?

<p>Inhibiting T cell differentiation (A)</p> Signup and view all the answers

What is the method used to collect cerebral fluid to determine inflammation in the central nervous system (CNS)?

<p>Spinal Tap or Lumbar puncture (B)</p> Signup and view all the answers

Which of the following is NOT a potential mechanism of action for Interferon-beta therapy in MS treatment?

<p>Inducing T cell proliferation (C)</p> Signup and view all the answers

What is the main function of corticosteroid therapy in Multiple Sclerosis?

<p>Induce apoptosis in lymphocytes (D)</p> Signup and view all the answers

Which therapy became the first oral drug to be approved for the treatment of Relapsing-Remitting Multiple Sclerosis (RRMS)?

<p>Oral dimethyl fumarate (C)</p> Signup and view all the answers

What is one potential mechanism of action of dimethyl fumarate therapy in MS?

<p>Reduces antigen-presenting capacity of APCs (B)</p> Signup and view all the answers

Which type of MS shows a decrease in relapses by 50% with dimethyl fumarate therapy?

<p>Relapsing-Remitting MS (RRMS) (A)</p> Signup and view all the answers

Which therapy was more recently approved for MS treatment in 2013?

<p>Oral cladribine (D)</p> Signup and view all the answers

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