15 Questions
What is the main cause of multiple sclerosis?
Inflammation leading to demyelination
Which type of immune cells cross the blood-brain barrier in multiple sclerosis?
Lymphocytes
What is the main function of Treg cells in multiple sclerosis?
Regulate autoreactive T cells
Which type of multiple sclerosis is characterized by steady disability progression without remissions or relapses?
Primary progressive MS
What is one of the symptoms commonly associated with multiple sclerosis?
Impaired gait
What do lesions observed by MRI indicate in multiple sclerosis?
Destruction of myelin sheath
Which therapy for Multiple Sclerosis (MS) is known to reduce relapses by approximately 30%?
Subcutaneous daclizumab
What is a potential mechanism of corticosteroids used in treating MS?
Inhibiting T cell differentiation
What is the method used to collect cerebral fluid to determine inflammation in the central nervous system (CNS)?
Spinal Tap or Lumbar puncture
Which of the following is NOT a potential mechanism of action for Interferon-beta therapy in MS treatment?
Inducing T cell proliferation
What is the main function of corticosteroid therapy in Multiple Sclerosis?
Induce apoptosis in lymphocytes
Which therapy became the first oral drug to be approved for the treatment of Relapsing-Remitting Multiple Sclerosis (RRMS)?
Oral dimethyl fumarate
What is one potential mechanism of action of dimethyl fumarate therapy in MS?
Reduces antigen-presenting capacity of APCs
Which type of MS shows a decrease in relapses by 50% with dimethyl fumarate therapy?
Relapsing-Remitting MS (RRMS)
Which therapy was more recently approved for MS treatment in 2013?
Oral cladribine
Learn about multiple sclerosis as a chronic autoimmune disease affecting the central nervous system. Understand the destruction of the myelin sheath around neurons, leading to symptoms like pain, fatigue, and impaired gait. Join Ms. Sarit Klein for insights in MIMM 214 - Introductory Immunology.
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