5 Questions
Which autoantibody is associated with Myasthenia Gravis?
ACh
Which of the following is associated with Coeliac Disease?
HLADQ2
Which type of graft rejection is mediated by IgM?
Hyperacute graft rejection
Which autoantibody is used as a biomarker for Rheumatoid Arthritis?
ACPA
Which of the following is associated with Ankylosing Spondylitis?
HLAB27
Study Notes
Autoantibodies and Diseases
- Autoantibodies against acetylcholine receptors (ACh) are involved in myasthenia gravis
- Autoantibodies against thyroid-stimulating hormone (TSH) are involved in Graves' disease
- Autoantibodies against thyroid peroxidase (anti-TPO) are involved in Hashimoto's thyroiditis
Autoantibodies as Biomarkers
- Autoantibodies against tissue transglutaminase (Anti-TTG) are used as biomarkers for Coeliac disease
Autoantibodies in Rheumatoid Arthritis
- Autoantibodies against citrullinated proteins (ACPA) are involved in Rheumatoid Arthritis
Autoantibodies in Systemic Lupus Erythematosus (SLE)
- Autoantibodies against complement component 1q (Anti-C1q) are involved in SLE, leading to excessive complement activation
Human Leukocyte Antigens (HLA) and Diseases
- HLA-B27 is associated with Ankylosing Spondylitis
- HLA-DQ2 is associated with Coeliac Disease
- HLA-DRB1 is associated with Rheumatoid Arthritis
Graft Rejection
- Hyperacute graft rejection is mediated by IgM antibodies, causing red blood cell (RBC) lysis
- Acute graft rejection is characterized by alloreactive T-cell infiltration
- Chronic graft rejection is characterized by alloreactive T-cells, alloantibodies, and fibrosis
This quiz covers autoimmune diseases, such as myasthenia gravis, Graves' disease, and rheumatoid arthritis, as well as organ transplant immunology, including hyperacute and acute graft rejection.
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