Applied Pathophysiology Chapter 2: Immunity
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Questions and Answers

What is indicated when a patient has four or more clinical criteria for SLE?

  • A strongly suggested diagnosis of SLE (correct)
  • A definitive diagnosis of a different autoimmune disorder
  • An immediate recommendation for hospitalization
  • A need for further testing to rule out other conditions
  • Which symptom is NOT listed as a clinical criterion for SLE diagnosis?

  • Leukopenia
  • Oral ulcers
  • Alopecia
  • Joint stiffness (correct)
  • What does the term 'serositis' refer to in the context of SLE?

  • Inflammation of the serous membranes lining organs (correct)
  • Inflammation of the central nervous system
  • Inflammation of the vascular tissue
  • Inflammation of the skin layers
  • Which of the following is a characteristic feature of acute cutaneous SLE?

    <p>Malar rash</p> Signup and view all the answers

    In which of the following scenarios would SLE diagnosis likely be reconsidered?

    <p>Patient reports fatigue and fever without other symptoms</p> Signup and view all the answers

    Which of the following may be a common misdiagnosis when evaluating a patient for SLE?

    <p>Chronic fatigue syndrome</p> Signup and view all the answers

    What does photophobia in SLE patients typically manifest as?

    <p>Increased sensitivity to light leading to discomfort</p> Signup and view all the answers

    What type of inflammation is characterized by joint pain and swelling in SLE diagnosis?

    <p>Synovitis</p> Signup and view all the answers

    Which statement correctly describes the approach to SLE diagnosis based on criteria?

    <p>Diagnosis is based on a combination of clinical criteria and symptoms</p> Signup and view all the answers

    Study Notes

    Systemic Lupus Erythematosus (SLE) Diagnosis

    • SLE criteria are continually updated, aiming for universal consensus on diagnosis.
    • Some patients may never meet the full diagnostic criteria for SLE, while others may take years to accumulate enough symptoms for a confirmed diagnosis.
    • A strong suggestion of SLE arises when a patient presents with four or more criteria.
    • Symptoms of SLE can overlap with other disorders, making diagnosis challenging.

    Clinical Criteria for SLE Diagnosis

    • Skin Manifestations: Acute/subacute cutaneous involvement includes a malar rash (butterfly rash), photosensitivity, and chronic cutaneous lesions such as discoid lupus (characterized by rough, scaly, raised red circles).
    • Oral Lesions: Presence of oral ulcers resembling aphthous ulcers, which can also appear in the nasal area.
    • Hair Loss: Alopecia typically presents as patchy thinning.
    • Joint Inflammation: Synovitis leads to pain and swelling, typically symmetric, affecting two or more joints, potentially migrating in location.
    • Serositis: Involves inflammation of serous membranes lining the lungs (pleura), heart (pericardium), and inner abdomen (peritoneum).
    • Hematological Changes: Includes hemolytic anemia and leukopenia.

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    Description

    This quiz focuses on Chapter 2 of 'Applied Pathophysiology for the Advanced Practice Nurse,' addressing altered immune responses. Explore the complexities of immunity, and understand how criteria for diagnosing conditions like systemic lupus erythematosus (SLE) can vary among patients. Enhance your knowledge of immune responses and their implications in patient care.

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