Apoptosis Pathways Quiz
10 Questions
9 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the role of apoptosis in cellular processes?

  • To promote uncontrolled cell growth
  • To prevent cells from dying
  • To allow cells to die in a programmed manner (correct)
  • To initiate cell division

How is apoptosis initiated in the extrinsic pathway?

  • By internal cellular signals
  • By FasL binding to Fas receptors on the surface of the target cell (correct)
  • By caspases self-activating
  • By the release of cytochrome c from mitochondria

What are the proteins that initiate apoptosis?

  • Collagens
  • Caspases (correct)
  • Keratins
  • Histones

Which pathway is often triggered by subsets of T lymphocytes?

<p>Extrinsic pathway (A)</p> Signup and view all the answers

What is the final step in the extrinsic pathway of apoptosis?

<p>Caspases activate each other in a self-amplifying process (A)</p> Signup and view all the answers

What role does apoptosis play in growth and development?

<p>Apoptosis plays a crucial role in growth and development, as well as in removing faulty cells.</p> Signup and view all the answers

What is apoptosis?

<p>Apoptosis is a cellular process that allows cells to die in a programmed manner.</p> Signup and view all the answers

What are the two pathways through which caspase activation can occur?

<p>The two pathways through which caspase activation can occur are the extrinsic pathway and the intrinsic pathway.</p> Signup and view all the answers

What is the role of FasL in the extrinsic pathway of apoptosis?

<p>FasL binds to Fas receptors on the surface of the target cell, initiating a series of intracellular events that ultimately lead to apoptosis.</p> Signup and view all the answers

What triggers the extrinsic pathway of apoptosis?

<p>The extrinsic pathway of apoptosis is often triggered by other cells, particularly subsets of T lymphocytes.</p> Signup and view all the answers

Flashcards

What is Apoptosis?

Apoptosis is a form of programmed cell death, a tightly regulated process that allows cells to die in a controlled manner. It involves a series of biochemical events that lead to the dismantling of the cell.

Extrinsic pathway

The extrinsic pathway of apoptosis is triggered by external signals, usually from other cells, such as cytotoxic T lymphocytes.

Intrinsic pathway

The intrinsic pathway of apoptosis is triggered by internal signals, often in response to cellular stress, such as DNA damage.

What is FasL?

FasL is a protein that acts as a ligand, binding to Fas receptors on the surface of target cells. This binding initiates the extrinsic pathway of apoptosis.

Signup and view all the flashcards

What are Caspases?

Caspases are a family of proteases (enzymes that break down proteins) that play a central role in apoptosis. They are activated in a cascade, leading to the dismantling of the cell.

Signup and view all the flashcards

Role of Apoptosis in Development

Apoptosis is essential for normal growth and development. It helps eliminate unwanted or damaged cells, sculpt organs and tissues, and maintain tissue homeostasis.

Signup and view all the flashcards

Triggers of Apoptosis

Apoptosis is triggered by a variety of stimuli, including DNA damage, growth factor deprivation, and cytotoxic T lymphocyte activation.

Signup and view all the flashcards

Apoptosis vs Necrosis

Apoptosis is a highly regulated process that differs from necrosis, which is an uncontrolled cell death that results from injury or trauma.

Signup and view all the flashcards

What happens during Apoptosis?

During apoptosis, the cell shrinks, its chromatin condenses, and its DNA fragments. The cell then breaks up into small membrane-bound vesicles called apoptotic bodies, which are phagocytosed by neighboring cells.

Signup and view all the flashcards

Importance of Apoptosis

Apoptosis is a critical process that plays a vital role in maintaining the health and integrity of multicellular organisms.

Signup and view all the flashcards

Study Notes

Apoptosis Overview

  • Apoptosis is a programmed cell death process essential for growth, development, and elimination of faulty cells.
  • Caspases, a family of proteases, initiate apoptosis by breaking down the cell from the inside.

Pathways of Apoptosis

  • Two primary pathways lead to caspase activation:
    • Extrinsic Pathway
    • Intrinsic Pathway (not detailed in the provided text)

Extrinsic Pathway

  • The extrinsic pathway is triggered by signals originating outside the cell.
  • Often activated by subsets of T lymphocytes through the engagement of Fas ligand (FasL).
  • FasL binds to Fas receptors on the target cell’s surface, signaling it to undergo apoptosis.
  • This binding initiates a cascade of intracellular signaling events directed by the Fas-associated death domain (FADD).
  • Ultimately, caspases engage in a self-amplifying activation process, leading to the rapid execution of apoptosis.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Description

Test your knowledge of apoptosis pathways with this quiz! Learn about the extrinsic and intrinsic pathways, caspase activation, and the role of apoptosis in cellular processes.

More Like This

Use Quizgecko on...
Browser
Open
Browser
Browser