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Apoptosis Pathways Quiz

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Questions and Answers

What is the role of apoptosis in cellular processes?

To promote uncontrolled cell growth

To prevent cells from dying

To allow cells to die in a programmed manner (correct)

To initiate cell division

How is apoptosis initiated in the extrinsic pathway?

By internal cellular signals

By FasL binding to Fas receptors on the surface of the target cell (correct)

By caspases self-activating

By the release of cytochrome c from mitochondria

What are the proteins that initiate apoptosis?

Collagens

Caspases (correct)

Keratins

Histones

Which pathway is often triggered by subsets of T lymphocytes?

Extrinsic pathway Signup and view all the answers

What is the final step in the extrinsic pathway of apoptosis?

Caspases activate each other in a self-amplifying process Signup and view all the answers

What role does apoptosis play in growth and development?

Apoptosis plays a crucial role in growth and development, as well as in removing faulty cells. Signup and view all the answers

What is apoptosis?

Apoptosis is a cellular process that allows cells to die in a programmed manner. Signup and view all the answers

What are the two pathways through which caspase activation can occur?

The two pathways through which caspase activation can occur are the extrinsic pathway and the intrinsic pathway. Signup and view all the answers

What is the role of FasL in the extrinsic pathway of apoptosis?

FasL binds to Fas receptors on the surface of the target cell, initiating a series of intracellular events that ultimately lead to apoptosis. Signup and view all the answers

What triggers the extrinsic pathway of apoptosis?

The extrinsic pathway of apoptosis is often triggered by other cells, particularly subsets of T lymphocytes. Signup and view all the answers

Study Notes

Apoptosis Overview

Apoptosis is a programmed cell death process essential for growth, development, and elimination of faulty cells.
Caspases, a family of proteases, initiate apoptosis by breaking down the cell from the inside.

Pathways of Apoptosis

Two primary pathways lead to caspase activation:
- Extrinsic Pathway
- Intrinsic Pathway (not detailed in the provided text)

Extrinsic Pathway

The extrinsic pathway is triggered by signals originating outside the cell.
Often activated by subsets of T lymphocytes through the engagement of Fas ligand (FasL).
FasL binds to Fas receptors on the target cell’s surface, signaling it to undergo apoptosis.
This binding initiates a cascade of intracellular signaling events directed by the Fas-associated death domain (FADD).
Ultimately, caspases engage in a self-amplifying activation process, leading to the rapid execution of apoptosis.

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Description

Test your knowledge of apoptosis pathways with this quiz! Learn about the extrinsic and intrinsic pathways, caspase activation, and the role of apoptosis in cellular processes.